Clinical trials of ayurvedic formulations in the treatment of acne vulgaris

Lalla, J. K.; Nandedkar, Sanjay; Paranjape, Meghana; Talreja, Neha

doi:10.1016/s0378-8741(01)00323-3

Cited by 62 publications

(43 citation statements)

References 7 publications

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“…Traditional therapeutics, for instance ayurvedic formulations [80], which are sometimes classified as complementary and alternative medicine (CAM), have been used in acne treatment. Therefore, plants that are currently used and those with a high potential are summarized as follows:…”

Section: Herbs For Acne Treatmentmentioning

confidence: 99%

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Therapeutic agents and herbs in topical application for acne treatment

Kanlayavattanakul

Lourith

2011

Intern J of Cosmetic Sci

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SynopsisAcne vulgaris suppresses an individual's self-confidence by causing distress with regard to physical appearance, which affects a significant number of individuals during puberty and is delineated by adolescence. Several treatments have been introduced to decrease the aesthetic and psychological problems caused by acne. The topical application of therapeutic agents has been found to be more feasible than hormonal treatment and laser therapy. The ingredients in topical acne treatments, particularly herbs and naturally derived compounds, have received considerable interest as they have fewer adverse effects than synthetic agents. Ré suméL'acné vulgaire touche à l'assurance d'un individu en causant une détresse face à son apparence physique. Elle affecte un nombre important d'individus pendant la puberté et est associée à l'adolescence. Plusieurs traitements ont été proposés pour diminuer les problèmes esthétiques et psychologiques causés par l'acné. L'application topique d'agents thérapeutiques a été estimée plus aisée qu'un traitement hormonal et une thérapie laser. Les ingrédients des traitements topiques de l'acné, particulièrement les plantes et les composés naturels dérivés ont suscité un intérêt considérable par leurs moindres effets indésirables que les ingrédients synthé-tiques.

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Section: Herbs For Acne Treatmentmentioning

confidence: 99%

“…However, A. vera was insignificant to suppress P. acnes-induced ROS and proinflammatory cytokines [82]. In the same ayurvedic formulation, Azadirachta indica, Curcuma longa and Hemidesmus incidus were used for acne treatment [80]. These herbs significantly suppressed the production of ROS induced by P. acnes [82].…”

Section: Already Used Herbsmentioning

confidence: 99%

Therapeutic agents and herbs in topical application for acne treatment

Kanlayavattanakul

Lourith

2011

Intern J of Cosmetic Sci

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“…It is characterized by open and closed comedones and inflammatory lesions like papules, pustules and nodules (Lalla et al, 2001). Micro-organisms like Propionibacterium acnes, S. aureus and S. epidermidis proliferate rapidly, leading to the development of acne.…”

Section: Introductionmentioning

confidence: 99%

Antiacne and wound healing activity of polyherbal topical gel comprising Andrographispaniculata (Burm.f.) Wall. ex Nees, Glycyrrhizaglabra L., Carica papaya L. and Cucurbitapepo L.

Shobha¹,

Roopashree²

2017

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Antiacne herbal formulations are used for the treatment of Acne vulgaris with the added advantage of not producing adverse effects unlike synthetic drugs. The present study has been designed with the objective for successive solvent extraction of Andrographis paniculata (Burm.f.) Wall. ex Nees (aerial parts), Glycyrrhiza glabra L. (roots), Carica papaya L.(seeds) and Cucurbita pepo L. (seeds), followed by development and evaluation of topical herbal gel formulation for antiacne and wound healing activity.In vitro antiacne activity was performed against Staphylococcus epidermis and Staphylococcus aureus, a causative organism for A. vulgaris, using agar well diffusion method. Three herbal gel formulations were developed comprising 2.5%, 5.0% and 10% of herbal mixture containing methanolic extracts of A. paniculata, G. glabra, C. papaya and C. pepo using Carbopol 934 as gel base. Formulations were evaluated for pH, viscosity, spreadability, extrudability, stability and acute skin irritancy test. Evaluation of wound healing potential was evaluated by excision wound model in wistar albino rats.Methanolic extracts exhibited highest zone of inhibition against S. epidermis and S. aureus than other solvent extracts. Antiacne potential of combined extracts was more than that of individual extracts (19.0±0.089). Developed gel formulations had good stability as per ICH guidelines. Formulations did not produce any skin irritation when observed for about 48 h on animal skin. Significant wound healing activity was observed in combined extracts and developed formulations as compared to standard and control group. The results were statistically significant. Hence, the study was successful in terms of establishing scientific data with regard to safety and effectiveness of selected herbal extracts in promoting antiacne activity in the form of a convenient, stable dosage form formulated using standardized extracts.

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“…Acne vulgaris, a chronic inflammatory disorder in adolescents consists of the pilosebaceous follicles, characterized by comedones, papules, pustules, cysts, nodules and often scars, chiefly on face, neck etc [1]. It is a skin condition that occurs due to the clogging of oil glands of the skin [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Efficacy and Safety of Perfact Face Gel and Perfact Face Tablets in Management of Acne

Yadav¹,

Singh²,

Chatterjee³

et al. 2011

J Clin Exp Dermatol

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Acne is a common disease of the pilosebaceous units of the skin and topical therapy is recommended for the management of acne with comedolytic, anti-inflammatory agents, along with antimicrobials. However, topical application of these drugs leads to frequent adverse effects and also, there is an emergence of antibiotic resistance by Propionibacterium acnes. Furthermore, systemic antimicrobial usage has been causally associated with various adverse events. No simple recipe for the treatment can be provided. Treatment options vary with the stage and severity of the disease. So now a day's physicians prefer the herboformulations containing Melaleuca alternifoli, Azadirachta indica, Curcuma longa, Piper nigrum, Aloe vera, Citrus bergamia, Santalum album, Rosa centifolia, Carica papaya etc. than the allopathic drugs due to less or no side effects. Perfact gel is herbal formulation contains 5% of Melaleuca alternifoli (Tea tree oil) and Perfact tablet is polyherbal formulations and contains extracts of Azadirachta indica, Curcuma longa, and Piper nigrum, and the study was conducted to evaluate the efficacy and safety of perfect face, Perfect face tablets and both in the management of acne.

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Clinical trials of ayurvedic formulations in the treatment of acne vulgaris

Cited by 62 publications

References 7 publications

Therapeutic agents and herbs in topical application for acne treatment

Therapeutic agents and herbs in topical application for acne treatment

Antiacne and wound healing activity of polyherbal topical gel comprising Andrographispaniculata (Burm.f.) Wall. ex Nees, Glycyrrhizaglabra L., Carica papaya L. and Cucurbitapepo L.

Evaluation of Efficacy and Safety of Perfact Face Gel and Perfact Face Tablets in Management of Acne

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