Clinical Trials with Topical Vitamin A Acid

(Juvenile) Pityriasis rubra pilaris

“…1,2,25,[93][94][95][96][97][98][99] General nutrition and healthcare should be a common denominator in all children when treating the disease. 1,2,25,[93][94][95][96][97][98][99] General nutrition and healthcare should be a common denominator in all children when treating the disease.…”

“…Oral vitamin A, cod liver oil, halibut liver oil, vitamin E, and carotene have all been tried with variable results. 25,[96][97][98][99][100][101][102][103] Isotretinoin at a dosage of 1-2.2 mg / kg / day for 12-16 weeks has been proven to be beneficial. 100 The advent of synthetic retinoids has brought about a revolution in the therapy of juvenile PRP, especially in recalcitrant cases.…”

“…Juvenile PRP has been treated using vitamin A, synthetic retinoids, diet supplements, and intensive and varied topical therapy. 1,2,25,[93][94][95][96][97][98][99] General nutrition and healthcare should be a common denominator in all children when treating the disease. Oral vitamin A, cod liver oil, halibut liver oil, vitamin E, and carotene have all been tried with variable results.…”

“…100 The advent of synthetic retinoids has brought about a revolution in the therapy of juvenile PRP, especially in recalcitrant cases. 25,[96][97][98][99][100][101][102][103] Isotretinoin at a dosage of 1-2.2 mg / kg / day for 12-16 weeks has been proven to be beneficial. 95,101 Etretinate has also been shown to be beneficial at a dosage of 0.5-1 mg / kg / day for 3-5 months.…”

Pityriasis rubra pilaris

“…These have included successful oral treatment with carotene, 44 cod 110 or halibut 43 liver oil , vitamin E with vitamin A, 111 and aqueous emulsified oral vitamin A in place of oil‐based vitamin A 112 . Beneficial topical vitamin A treatment was also reported 113 …”