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ALTERATIONS IN SUN-DAMAGED SKIN 533cally affected gargoyles excrete significantly increased quantities of mucopolysaccharide. The known carriers and most of the siblings are in or near the normal range. Based on these quantitative data it is not yet possible to identify carriers by these procedures.Since the analytical methods employed yield values for total mucopolysaccharide without distinguishing among the various types which may be present, the present results do not preclude the existence of qualitative differences between carriers and normal individuals which would not be quantitatively evidenced. Such qualitative differences are currently being investigated.Summary. The urinary mucopolysaccharide excretion of a family with the sex-linked form of gargoylism has been quantitatively studied, using several methods. The results indicate that neither carriers nor unaffected siblings excrete significantly higher than normal quantities of total acid mucopolysaccharides. 1. McKusick, V. A., Hereditable Disorders of Con-2. Brante, G., Scandinav.

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