Clinical Use of a Bioresorbable Matrix Barrier in Guided Tissue Regeneration Therapy. Case Series

Abstract

In this case series study 19 Class II furcations and 47 intrabony defects in 59 patients were treated according to the principles of guided tissue regeneration using a bioresorbable matrix barrier. Gingival condition and device exposure were assessed at 2 weeks, and 1, 3, 6, and 12 months after surgery. The effect of therapy was evaluated by assessing probing depths (PD), probing attachment level (PAL), and the position of the gingival margin prior to surgery and 12 months after surgery. Mild clinical signs of inflammation in the soft tissue covering the device was found adjacent to 3 defects only and limited to the first month of healing. Device exposure occurred at 10 out of the 66 defects. At the furcation defects, the mean PD reduction amounted to 3.7 mm (P < or = 0.001). Mean gain PAL vertical was 3.4 mm and PAL horizontal 3.3 mm (P < or = 0.001), resulting in complete closure of 9 out of the 19 defects. Mean gingival recession was 0.2 mm. At the intrabony defects mean PD reduction was 5.4 mm and mean gain of PAL 4.9 mm (P < or = 0.001). Gingival recession averaged 0.5 mm (P < or = 0.05). It was concluded that the use of the matrix barrier in GTR therapy resulted in 1) reduced probing depths; 2) pronounced gain of clinical attachment; and 3) a very low incidence of gingival pathology, gingival recession, and device exposure.

An evaluation of a resorbable (semirigid) GTR membrane in human periodontal intraosseous defects: A clinicoradiological re-entry study

“…[6–8] In the present study, an attempt has been made to regenerate the lost periodontium in infrabony periodontal defects in human mandibular molar areas using a semi-rigid, resorbable membrane.…”

Periodontal Regeneration Using the Mixture of Human Tooth-ash and Plaster of Paris in Dogs

“…As a result, extensive efforts had been employed to utilize bioresorbable membranes to achieve therapeutic purpose in clinical trials 7,[32][33][34][35] . In clinical practice, the tissue regeneration barrier membranes are generally required to maintain their barrier functions for 4 to 6 weeks in order to secure the restoration of periodontal tissues 36) .…”

Long‐Term Maintenance of Alveolar Bone Gain After Implantation of Autolyzed, Antigen‐Extracted, Allogenic Bone in Periodontal Intraosseous Defects

“…Thus, gained alveolar bone and probing attachment following the implantation of AAA bone and following GTR using ePTFE membranes may be maintained over a long period in patients practicing good oral hygiene and receiving supportive periodontal therapy. [18][19][20][21][22][23][24][25][26][27][28][29][30] Bone level measurements by sounding under local anesthesia were found to correlate highly with intraoperative bone level measurements (r = 0.97, < 0.0001). This finding indicates that re-entry procedures to determine alveolar bone gain after regenerative procedures may be unnecessary, thereby facilitating patient recruitment and compliance for clinical trials assessing long-term treatment outcomes of regenerative procedures.…”