Clinical Use of Growth Factors in the Improvement of Skin Wound Healing

Abstract

To discuss the normal mechanism of wound healing (WH), the role of growth factors (GF) in preclinical and clinical studies and its importance in the healing of abnormal wound therapy. For search, we used the PUBMED and LILACS database, and the following descriptors: skin, wound healing, growth factor and clinical trials. We also prioritized the analysis of the Clinical Trials in the previous 10 years. Although there are many studies being conducted in the pre-clinical phase, we see that there are few studies in the clinical phase. 274 studies were identified, and 58 were selected. After tissue injury, repair occurs through coordinated biological actions that are healing. The importance of the study of healing in the skin is not only because of its anatomical location, easy access and exposure, but also because of its vital function. There is accumulating evidence that the process of healing after injury may be mediated by several GF. However, may this class of molecules even act effectively on the clinical response of this pathological condition? Many preclinical studies (in vitro and in vivo) reinforce the importance and efficacy of GF in the regeneration of damaged skin. Furthermore, recent studies have reported the use in adjuvant or not, of GF in clinical treatment to improve WH in humans. Therefore, we conclude that it seems to be effective by the use of GF in adjuvant or not in WH. However, it still seems to be necessary to carry out more clinical trials in phase I and II.

Effect of Freeze-dried Amnion with Human Amniotic Stem Cells Seeding on the Expression of FGF-2 and the Number of Fibroblasts in Vesicovaginal Fistula: An Animal Study

“…This growth factor is produced by inflammatory cells, endothelial cells, fibroblasts, and keratinocytes. The mechanism of FGF-2 in the wound healing process has been known both in vitro and in vivo, namely through its mechanism in activating local macrophages, increasing the production of extracellular matrix components, fibroblast proliferation, proliferation and migration of endothelial cells for angiogenesis and re-epithelialization (Cornick et al 2014). The study by Tanaka et al (1996) showed a decreased amount of FGF-2 in a diabetic rat model.…”