Clinical Use of Medium Chain Triglycerides

Ruppin, David C.; Middleton, W. R. J.

doi:10.2165/00003495-198020030-00005

Cited by 49 publications

(28 citation statements)

References 3 publications

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“…The benefits derived through blending vegetable oils with RCNO for the non-coconut oil consumer were incorporation of the MCFA and improved oxidative stability, without imparting any coconut oil flavor/aroma to the blends. These blends might also show 13% of the fat not being deposited in the body (due to the presence of 20% of coconut oil) [2,3,[17][18][19].…”

Section: Fatty Acid Compositionmentioning

confidence: 99%

Fatty Acid Composition, Oxidative Stability, and Radical Scavenging Activity of Vegetable Oil Blends with Coconut Oil

Bhatnagar

Kumar

Hemavathy

et al. 2009

J Americ Oil Chem Soc

151

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Section: Fatty Acid Compositionmentioning

confidence: 99%

Fatty Acid Composition, Oxidative Stability, and Radical Scavenging Activity of Vegetable Oil Blends with Coconut Oil

Bhatnagar

Kumar

Hemavathy

et al. 2009

J Americ Oil Chem Soc

151

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“…From these observations, it is likely that colonic absorption of MCFAs may be responsible for a large part of the benefit seen with oral medium chain triacylglycerol (MCT) therapy to patients with compromised small bowel function. 20 The ability of the colon to absorb octanoate was directly demonstrated by measuring octanoate appearance in the mesenteric venous blood, along with its metabolites, over a wide concentration range ( fig 3A). This luminal substrate was available to the epithelial cells for oxidation to CO 2 and ketone bodies, and for other metabolic processes within the cell (table 1).…”

Section: Discussionmentioning

confidence: 99%

“…MCTs are in fact already used in a range of malabsorptive disorders, as substitution of medium chain for long chain triacylglycerols (LCT) has been shown to reduce fat excretion. 20 Although this reduction has been explained by a more rapid absorption of MCT than of LCT in the small bowel, 21 22 colonic absorption of MCFAs may have been a contributing factor. This view is supported by a study in short bowel patients where substitution of MCT for 50% of existing dietary LCT was done.…”

Section: Discussionmentioning

confidence: 99%

Absorption and metabolism of octanoate by the rat colon in vivo: concentration dependency and influence of alternative fuels

Jørgensen

Fitch²,

Mortensen³

et al. 2002

Gut

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Background: Compared with short and long chain fatty acids, medium chain fatty acids (MCFAs) have been shown to provide the highest colonic absorption of substrate carbon. Moreover, colonic epithelial cells fulfil their basic energy requirements as easily from MCFAs as from short chain fatty acids. Aims: To further characterise octanoate as a colonic luminal substrate, we determined in vivo the influence of (i) substrate concentration and (ii) alternative luminal fuels, on rat colonic transport and metabolism. Methods: Segments of rat proximal colon (8 cm) were cannulated and perfused for 100 min with

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“…Specifically, our purpose was to determine the effects of our experimental conditions on the percentage of biliary acids, the interrelation between bile acids and bile lipids, and the lithogenic index. In addition, we studied whether the addition of exogenous bile acid (ursodeoxycholic acid) absorbed passively by the intestine (Ruppin & Midleton, 1980;Rutgeerts et al 1982;Sthiel, Raedesch & Rudolph, 1988) was partly able to compensate for the disruption of enterohepatic circulation.…”

Section: Introductionmentioning

confidence: 99%

Effect of intestinal resection, type of dietary fat and time on biliary lipid secretion in rats

Gómez-Ayala

Lisbona²,

López-Áliaga³

et al. 1994

Experimental Physiology

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SUMMARYThe effects of time and the type of dietary fat on biliary physiology in rats with 50 % resection of the distal small intestine were investigated. The effects of ursodeoxycholic acid as an exogenous source of bile acid added to the diet were also studied. The fat composition of all diets was the same in quantitative terms (4 %), and differed only in the type of lipid supplied: olive oil (diet A) or one-third medium chain triglycerides, one-third sunflower seed oil and onethird olive oil (diet B). In resected rats given diet A for 1 or 3 months, there was a decrease in biliary secretion of cholesterol and phospholipids, and in the lithogenic index, with respect to the control group. Resected rats fed diet B for 1 or 3 months showed increases in biliary secretion of cholesterol and phospholipids, and in the lithogenic index, in comparison with resected rats fed diet A. The addition of ursodeoxycholic acid to diet B led to the decoupling of bile acid and bile lipid secretion.

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Clinical Use of Medium Chain Triglycerides

Cited by 49 publications

References 3 publications

Fatty Acid Composition, Oxidative Stability, and Radical Scavenging Activity of Vegetable Oil Blends with Coconut Oil

Fatty Acid Composition, Oxidative Stability, and Radical Scavenging Activity of Vegetable Oil Blends with Coconut Oil

Absorption and metabolism of octanoate by the rat colon in vivo: concentration dependency and influence of alternative fuels

Effect of intestinal resection, type of dietary fat and time on biliary lipid secretion in rats

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