Clinical use of polyethylene glycols as marker substances and determination in urine by liquid chromatography

Gauchel, Gisela; Huppertz, Bernd; Feiertag, Heribert; Keller, R.

doi:10.1016/s1570-0232(02)00925-x

Cited by 22 publications

(27 citation statements)

References 27 publications

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“…Possible reasons for this might include a future interest in receiving take-home prescriptions, and the fear of 'disappointing' the treating physicians and nurses. The use of polyethyleneglycol markers has been proven to be easy to perform, safe and reliable [6,7] . Applying this marker, our preliminary data indicate that the prevalence of undetected concomitant drug consumption in ambulatory replacement therapy is much higher than previously assumed.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of a Polyethylene Glycol Marker System in Urine Drug Screening in an Opiate Substitution Program

et al. 2008

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Aims: Screening for concomitant drug consumption is necessary in opiate substitution therapy of opiate-dependent patients. Adulteration of samples is a common problem in this setting. A recently developed polyethylene glycol marker system allows reliable identification of urine samples. In this study, we aimed to compare the rates of drug detection in conventional and marker urine samples. Design: This cross-sectional evaluation was performed in an ambulatory opiate substitution program. We studied 55 opiate-dependent patients (32 men, 23 women). In all patients we compared the rates of drugs detected in the marker urine with the most recent conventional urine control. Additionally we assessed the rate of marker urine manipulation. Findings: In the conventional urine controls, opiates and benzodiazepines were found in 3.6 and 27%, respectively, whereas in the marker urine controls, these rates were 33 and 40%, respectively. Signs of urine manipulation were present in 35%. The rates of concomitant consumption and urine manipulation were higher among the patients without than among those with take-home substitution. Conclusions: With the marker urine, an unexpectedly high prevalence of concomitant consumption can be found. Marker urine testing has a significantly higher sensitivity for the detection of concomitant drug use.

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Section: Discussionmentioning

confidence: 99%

“…Recently, an orally ingestible marker system for urine samples has been developed [6,7] . It uses biologically inert low-molecular-weight polyethylene glycols that are rapidly excreted with the urine after oral ingestion.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a Polyethylene Glycol Marker System in Urine Drug Screening in an Opiate Substitution Program

et al. 2008

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“…After 30 min they were allowed to deliver urine without supervision. Patient urines were chromatographed on Nucleosil C18 and C8 in 45% aqueous methanol as described elsewhere (15). …”

Section: Methodsmentioning

confidence: 99%

Urine labeling with orally applied marker substances in drug substitution therapy

Huppertz

Gauchel²,

Feiertag³

et al. 2004

Clinical Chemistry and Laboratory Medicine (CCLM)

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The compliance of 581 drug addicts attending six methadone substitution outpatient clinics was determined over a period of 18 months. Urine from these patients was labeled following oral administration of low molecular weight polyethylene glycols as marker substances. These substances were measured in approx. 5800 urine samples. A protocol for applying marker substances and ways to prevent substitution of urine samples were evaluated. Normal values for marker substances in urine were determined. The results suggest that this labeling procedure is a new diagnostic tool to prevent manipulation of urine samples by drug addicts receiving substitution therapy.

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“…11,323 samples were investigated for marker substances previously described [14,15] and 9,937 samples were investigated for DOA.…”

Section: Introductionmentioning

confidence: 99%

False Negative Results in Testing for Drugs of Abuse from Diluted Urine

2017

International Journal of Clinical Chemistry and Laboratory Medi

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Clinical use of polyethylene glycols as marker substances and determination in urine by liquid chromatography

Cited by 22 publications

References 27 publications

Efficacy of a Polyethylene Glycol Marker System in Urine Drug Screening in an Opiate Substitution Program

Efficacy of a Polyethylene Glycol Marker System in Urine Drug Screening in an Opiate Substitution Program

Urine labeling with orally applied marker substances in drug substitution therapy

False Negative Results in Testing for Drugs of Abuse from Diluted Urine

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