Clinical usefulness of linked color imaging for evaluation of endoscopic activity and prediction of relapse in ulcerative colitis

Matsumoto, Kenta; Oka, Shiro; Tanaka, Shinji; Inagaki, Kenji; Okamoto, Yuki; Tanaka, Hidenori; Naito, Toshikatsu; Wakai, Masaki; Yamashita, Ken; Ninomiya, Yuki; Hayashi, Ryohei; Kitadai, Yasuhiko; Shimamoto, Fumio; Chayama, Kazuaki

doi:10.1007/s00384-020-03810-9

Cited by 5 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A retrospective Japanese study demonstrated that LCI could better identify histological mucosal inflammation (defined by GS 2–3) by detecting redness in the colonic mucosa, and better predict relapse in UC than WLE. 27 These findings suggest that LCI can be a useful tool for detecting mucosal inflammation in patients with IBD. However, in a recent meta-analysis of 12 studies that compared the correlation between endoscopy (MES, UCEIS, PICaSSO) and histological disease activity scores (GS, NHI, RHI, NYMS) across SD-WLE, HD-WLE, and VCE in patients with UC, endoscopic activity scores demonstrated a strong correlation with histologic scores regardless of the endoscopic platform.…”

Section: Endoscopic Evaluation For Disease Activitymentioning

confidence: 86%

See 1 more Smart Citation

Current status of image-enhanced endoscopy in inflammatory bowel disease

Yang

2023

Clin Endosc

View full text Add to dashboard Cite

In inflammatory bowel disease (IBD), chronic inflammation leads to unfavorable clinical outcomes and increases the risk of developing colorectal neoplasm (CRN); thereby highlighting the importance of endoscopically evaluating disease activity as well as detecting and characterizing CRN in patients with IBD. With recent advances in image-enhanced endoscopic (IEE) technologies, especially virtual chromoendoscopy (VCE) platforms, this review discusses state-of-the-art IEE techniques and their applicability in assessing disease activity and surveillance colonoscopy in patients with IBD. Among various IEE, VCE demonstrated the capacity to identify quiescent disease activity. And endoscopic remission defined by the new scoring system using VCE platform better predicted clinical outcomes, which may benefit the tailoring of therapeutic strategies in patients with IBD. High-definition dye-chromoendoscopy (HD-DCE) is numerically superior to high-definition white light endoscopy (HD-WLE) in detecting CRN in IBD; however, discrepancy is observed in the statistical significance. VCE showed comparable performance in detecting dysplasia to HD-WLE or DCE and potential for optical diagnosis to differentiate neoplastic from nonneoplastic lesions during surveillance colonoscopy. Applying these novel advanced IEE technologies would provide opportunities for personalized medicine in IBD and optimal treatment of CRN in patients with IBD.

show abstract

Section: Endoscopic Evaluation For Disease Activitymentioning

confidence: 86%

“…Table 3 summarizes representative studies evaluating disease activity in IBD using IEE. [15][16][17][18][19][22][23][24][25][26][27]…”

Section: Endoscopic Evaluation For Disease Activitymentioning

confidence: 99%

Current status of image-enhanced endoscopy in inflammatory bowel disease

Yang

2023

Clin Endosc

View full text Add to dashboard Cite

show abstract

“…However, it is important to note that even in cases diagnosed as MES 0, a 9.4% relapse was observed. In recent studies that included the endoscopic mucosal evaluation of UC, there have been several reports of relapse in patients presenting with MES 0 mucosa, including 20.0% at 12 months, 16 28.6% at 30 months, 17 18.8% at 80 months, 18 25.9% at 48 months, 19 and 9.2% at 400 days 20 of observation. These results suggest that the diagnosis of MH by endoscopy, defined as MES 0, is not sufficient to predict subsequent clinical relapse.…”

Section: Discussionmentioning

confidence: 99%

Mucosal interleukin‐8 expression as a predictor of subsequent relapse in ulcerative colitis patients with Mayo endoscopic subscore 0

Uchiyama

Takagi

Mizushima

et al. 2022

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…Matsumoto et al [21] also reported the clinical utility of LCI for the assessment of endoscopic activity and prediction of relapse in patients with quiescent UC. They classified the endoscopic findings of the entire rectum into three groups: WLI−/LCI− (group A, WLI nonredness/LCI nonredness), WLI−/LCI+ (group B, WLI nonredness/LCI redness), and WLI+/LCI+ (group C, WLI redness/LCI redness), based on the presence or absence of obvious planar redness on a combination of WLI and LCI observation.…”

Section: Linked-color Imagingmentioning

confidence: 99%

Possible Role of Image-Enhanced Endoscopy in the Evaluation of Mucosal Healing of Ulcerative Colitis

Matsuura¹,

Saito²,

Miyoshi³

et al. 2022

Digestion

View full text Add to dashboard Cite

Background: Mucosal healing (MH) is recognized as a therapeutic target in ulcerative colitis (UC) because of evidence that it is associated with favorable clinical outcomes. Current endoscopic assessment of MH by conventional white-light endoscopy is subject to several important clinical issues including the subjective nature of assessment, intra- and interobserver variability, and persistent microscopic inflammation, even in mucosa it was observed as quiescent on conventional endoscopy. Summary: Advances in image-enhancement technologies enable the provision of high-contrast images that emphasize the mucosal structures, blood vessel patterns, and color tones of the intestinal mucosa, and recently, several image-enhanced endoscopy (IEE) techniques have become available for the assessment of MH in UC. Narrow-band imaging and dual-red imaging facilitate visualization of mucosal vascular structures, which is useful for detecting minor inflammation and predicting relapse because of the capturing of information on incomplete vascular regeneration in patients with UC. Linked-color imaging (LCI) is optimized to emphasize the redness of the mucosa and blood vessels, and is superior for depicting subtle color changes arising from mucosal inflammation. LCI could possibly be used to stratify UC patients with MH on conventional endoscopy. Autofluorescence imaging and i-scan can also depict subtle histological changes underlying the healing of mucosa in UC, revealing them as simple color changes. Key Messages: Accumulating evidence suggests that IEE techniques could overcome current unmet needs in the endoscopic assessment of MH in UC and contribute to improving therapy based on treat-to-target strategies.

show abstract

Clinical usefulness of linked color imaging for evaluation of endoscopic activity and prediction of relapse in ulcerative colitis

Cited by 5 publications

References 39 publications

Current status of image-enhanced endoscopy in inflammatory bowel disease

Current status of image-enhanced endoscopy in inflammatory bowel disease

Mucosal interleukin‐8 expression as a predictor of subsequent relapse in ulcerative colitis patients with Mayo endoscopic subscore 0

Possible Role of Image-Enhanced Endoscopy in the Evaluation of Mucosal Healing of Ulcerative Colitis

Contact Info

Product

Resources

About