Clinical utility of dual-energy CT for gout diagnosis

Huijuan, Hu; Liao, Meiyan; Xu, Lei

doi:10.1016/j.clinimag.2014.12.015

Cited by 53 publications

(36 citation statements)

References 29 publications

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“…The use of high‐frequency sonography, dual‐energy computed tomography (CT), and magnetic resonance imaging can reveal findings indicative of gout, even early in gout pathogenesis, thereby securing a role in the early diagnosis and management of gout. However, magnetic resonance imaging is expensive and has poor specificity; dual‐energy CT enables simultaneous direct visualization of MSU crystal deposits and bone structures and is, thus, sensitive, noninvasive, and reproducible for gout diagnosis . The high costs and necessity of a special scanning machine, however, may limit dual‐energy CT use.…”

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confidence: 99%

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Combining Hyperechoic Aggregates and the Double-Contour Sign Increases the Sensitivity of Sonography for Detection of Monosodium Urate Deposits in Gout

et al. 2017

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confidence: 99%

“…However, magnetic resonance imaging is expensive and has poor specificity 9 ; dual-energy CT enables simultaneous direct visualization of MSU crystal deposits and bone structures and is, thus, sensitive, noninvasive, and reproducible for gout diagnosis. 10,11 The high costs and necessity of a special scanning machine, however, may limit dual-energy CT use.…”

mentioning

confidence: 99%

Combining Hyperechoic Aggregates and the Double-Contour Sign Increases the Sensitivity of Sonography for Detection of Monosodium Urate Deposits in Gout

et al. 2017

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“…It allows the visualization of tophi as its chemical properties differ from others. It has a sensitivity of 91.9% and specificity of 85.4%, but it is costly and not widely available [12]. …”

Section: Discussionmentioning

confidence: 99%

Spinal gout causing reversible quadriparesis: a case report and literature review

Kaler

Mukhtar

Khalid

et al. 2018

Journal of Community Hospital Internal Medicine Perspectives

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Gout commonly affects peripheral joints and is rarely found in axial joints, such as the spine and sacroiliac joints. We report a case of a patient that presented with quadriparesis who was empirically treated for spinal gout and a review of relevant literature. A 77-year-old male presented with new-onset quadriparesis that developed over 3 days. MRI imaging was suggestive of tophaceous gout of the cervical spine, but our patient refused a spinal biopsy. He was empirically treated with high-dose steroids and his upper and lower extremities weakness started improving within 3 days and resolved completely. Although spinal gout is uncommon, this case indirectly suggests that gout should be kept as a differential diagnosis when faced with back pain or quadriparesis. This case implies that empiric treatment should be considered when radiographic evidence is suggestive of tophaceous gout of the spine.

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“…DECT showed a reduction in tissue urate deposits compared with baseline images following treatment. 1,49 Kiefer et al 50 showed that DECT detected more erosions than standard CT alone and that DECT had the best diagnostic value with suitable interobserver reliability for gout. DECT has moderate sensitivity in non-tophaceous gout and high sensitivity in tophaceous gout.…”

Section: Tip 4: Monosodium Urate Crystal Detection and Quantificationmentioning

confidence: 99%

Top-Ten Tips for Dual-Energy CT in MSK Radiology

Walstra

Hickle

Duggan

et al. 2019

Semin Musculoskelet Radiol

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Dual-energy computed tomography (DECT) has the potential to detect musculoskeletal pathology with greater sensitivity than conventional CT alone at no additional radiation dose to the patient. It therefore has the potential to reduce the need for further diagnostic imaging or procedures (e.g., joint aspirations in the case of gout or magnetic resonance imaging to confirm undisplaced fractures).DECT is a well-established technique for the detection of gout arthropathy. Multiple newer applications have shown clinical potential including bone marrow edema detection and metal artifact reduction. Collagen analysis, bone marrow lesion detection, and iodine mapping in CT arthrography are areas of possible future application and development.This article outlines 10 tips on the use of DECT imaging of the musculoskeletal system, explaining the technique and indications with practical suggestions to help guide the radiologist.

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Clinical utility of dual-energy CT for gout diagnosis

Cited by 53 publications

References 29 publications

Combining Hyperechoic Aggregates and the Double-Contour Sign Increases the Sensitivity of Sonography for Detection of Monosodium Urate Deposits in Gout

Combining Hyperechoic Aggregates and the Double-Contour Sign Increases the Sensitivity of Sonography for Detection of Monosodium Urate Deposits in Gout

Spinal gout causing reversible quadriparesis: a case report and literature review

Top-Ten Tips for Dual-Energy CT in MSK Radiology

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