Clinical Utility of FDG–PET and PET/CT in Non-malignant Thoracic Disorders

Basu, Sandip; Saboury, Babak; Werner, Tom; Alavi, Abass

doi:10.1007/s11307-010-0459-x

Cited by 44 publications

(40 citation statements)

References 51 publications

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“…For many years, nuclear imaging using 67gallium (67Ga) has played an important role in the assessment of sarcoidosis (22). In recent years, 18F-FDG PET has been proposed to be a useful modality for the diagnosis and management of patients with inflammatory processes, particularly sarcoidosis (23,24). According to a previous review, whole-body 18F-FDG PET has been reported to be more sensitive than 67Ga scans for assessing the activity of sarcoidosis and demonstrates great value in detecting occult diagnostic biopsy sites (25).…”

Section: Discussionmentioning

confidence: 99%

A Japanese Case of Vertebral Sarcoidosis

et al. 2013

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We herein report the first Japanese case of vertebral sarcoidosis diagnosed using multiple imaging modalities and a biopsy. CT, MRI and (18)F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) detected multiple vertebral lesions, and a vertebral biopsy guided by the PET findings confirmed the diagnosis of vertebral sarcoidosis. Although the disease was refractory to corticosteroids, treatment with methotrexate (MTX) achieved a good response. Our case suggests that MRI and 18F-FDG PET are useful for determining the site for a biopsy and that MTX is effective for treating vertebral sarcoidosis.

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Section: Discussionmentioning

confidence: 99%

A Japanese Case of Vertebral Sarcoidosis

et al. 2013

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“…Sarcoidosis is a chronic systemic inflammatory disease of unknown origin involving preferentially lungs often with associated hilar and mediastinal adenopathy. Characteristic radiologic and PET features of thoracic sarcoidosis are well recognized by clinicians and imagers and are actually used to follow the status of patients undergoing treatment [15,16] .…”

Section: Inflammationmentioning

confidence: 99%

Features of non-malignant thoracic lesions on F-18 FDG PET/CT scan

Nguyen

2014

IJDI

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Introduction: During PET/CT chest interpretation, the radiologist may encounter non-malignant positive findings originating from physiologic variants, inflammation, infection, iatrogenic causes, post-surgical/post-therapeutic changes and benign tumors of different components of the thorax. This article illustrates and raises the awareness of these benign FDG-avid findings. Methods:We use a search engine to retrospectively review the 10-year PET/CT and pathology database of our institution for cases with thoracic findings linked to physiologic variations, and to benign processes and diseases. The keywords used for the search include all the entities presented in this article. We select the cases presenting with the most didactic value of benignity related to (1) established imaging patterns already published in the literature, which serves as reference articles in this paper, (2) final diagnosis from tissue sampling of ambiguous and difficult cases, and (3) long term monitoring based on clinical evaluation and anatomic and functional imaging.Results: Among the pool of cases fulfilling the required search criteria, we choose the most illustrative ones to present the different categories of benign findings encompassing the physiologic variants, inflammation, infection, iatrogenic causes, post-operative and post-therapeutic changes, and benign neoplasms. The most representative reference articles of the presented cases concerning all the benign thoracic entities are selected for the bibliography. Conclusion:The presented PET/CT cases raise the awareness and strengthen the interpretation confidence of the radiologist during the evaluation of cancer. The familiarity with these benign thoracic entities would obviate any suspicion of malignancy and avoid unnecessary additional assessment using expansive and potentially harmful procedures.

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“…Un hypermétabolisme peut à la fois être constaté dans les infections mycobactériennes, ou bactériennes classiques, fongiques ainsi que dans les granulomatoses ( Fig. 3 et 4) au premier rang desquelles la sarcoïdose [9]. D'autres lésions bénignes peuvent apparaître avides au 18 F-FDG comme l'hamartome ( Fig.…”

Section: Les Lésions Bénignes Du Poumonunclassified