2010
DOI: 10.1002/hed.21566
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Clinical utility of PET/CT in the evaluation of head and neck squamous cell carcinoma with an unknown primary: A prospective clinical trial

Abstract: An unknown primary should be diagnosed only after a complete head and neck examination, flexible endoscopy, and CT or MRI. PET/CT performed prior to panendoscopy will increase the diagnostic yield in the unknown head and neck primary population, leading to more targeted, and less morbid, treatment.

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Cited by 92 publications
(80 citation statements)
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“…PET imaging allows a more accurate nodal staging of locally advanced head and neck cancer (Kyzas et al, 2008;Yoo et al, 2013), and could result in changing the therapeutic management in nearly 15% of patients (Lonneux et al, 2010). For patients with cervical node metastases of unknown primary, PET/CT detected a primary tumor in nearly 30% of patients (Rudmik et al, 2011;Wong et al, 2012;Zhu and Wang, 2013).…”
Section: Introductionmentioning
confidence: 99%
“…PET imaging allows a more accurate nodal staging of locally advanced head and neck cancer (Kyzas et al, 2008;Yoo et al, 2013), and could result in changing the therapeutic management in nearly 15% of patients (Lonneux et al, 2010). For patients with cervical node metastases of unknown primary, PET/CT detected a primary tumor in nearly 30% of patients (Rudmik et al, 2011;Wong et al, 2012;Zhu and Wang, 2013).…”
Section: Introductionmentioning
confidence: 99%
“…25,26,[28][29][30][31][32][33][34] Rusthoven and colleagues 34 summarized 16 retrospective studies with a total of 302 patients with HNCUP who had FDG-PET, and reported that PET had a sensitivity of 88% and a specificity of 75% in detecting a primary tumor. PET detected 24.5% of primary tumors that were not detected by conventional workup.…”
Section: Results Of Pet Without Integrated Ct In Hncupmentioning
confidence: 99%
“…However, these investigations fail to reveal a primary lesion in 2% to 8% of cases. 19,[23][24][25][26] The next step in the workup of these patients varies among institutions. Some clinicians will proceed to examination under anesthesia (EUA) with biopsies of clinically suspicious and clinically probable sites, whereas others will perform PET before EUA.…”
Section: Conventional Workupmentioning
confidence: 99%
“…PET is also helpful for several cancer diagnosis indications. These include determining whether a suspicious lesion is likely to be malignant (e.g., evaluation of a solitary pulmonary nodule) [1,2] and assessing lesions with indeterminate biopsy results or that are inaccessible for biopsy (so-called metabolic biopsy) [3,4]; identifying the site of an unknown primary cancer in a patient with proven or strongly suspected metastatic disease [5][6][7][8]; and detecting an occult primary cancer in a patient with a suspected paraneoplastic syndrome [9][10][11].…”
Section: Introductionmentioning
confidence: 99%