Clinical utility of procalcitonin and its association with pathogenic microorganisms

Xu, Hua‐Guo; Tian, Meng; Pan, Shiyang

doi:10.1080/10408363.2021.1988047

Cited by 15 publications

(7 citation statements)

References 128 publications

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“…On the other hand, an inverse association between PCT level and COVID-19 severity detected in this study could also be true, which explained by the suppressive effect of the virus on this parameter. Previous studies have demonstrated that PCT synthesis could be inhibited during viral infection, possibly by the activity of interferon (IFN)-gamma whose concentration also increases along with this condition [ 62 , 63 ]. Therefore, the usefulness of this parameter as a predictor of COVID-19 severity needs to be further verified by ruling out the possible influence of the underlying conditions.…”

Section: Discussionmentioning

confidence: 99%

Age, comorbidities, c-reactive protein and procalcitonin as predictors of severity in confirmed COVID-19 patients in the Philippines

Acedera¹,

Sirichokchatchawan²,

Brimson³

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Age, comorbidities, c-reactive protein and procalcitonin as predictors of severity in confirmed COVID-19 patients in the Philippines

Acedera¹,

Sirichokchatchawan²,

Brimson³

et al. 2023

Heliyon

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“…Its use as a potential marker of infection was first described by Spanish researchers in 1975. PCT, the calcitonin prohormone, is produced in response to the release of endotoxin or mediators released in response to bacterial infections and has a strong correlation with the severity and extent of infection [ 44 ]. Normal values are considered 0.05–0.09 ng/mL.…”

Section: The Best Biomarkers In Intensive and Perioperative Carementioning

confidence: 99%

Biomarkers as Prognostic Predictors and Therapeutic Guide in Critically Ill Patients: Clinical Evidence

Hernández

Rueda

2023

JPM

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A biomarker is a molecule that can be measured in a biological sample in an objective, systematic, and precise way, whose levels indicate whether a process is normal or pathological. Knowing the most important biomarkers and their characteristics is the key to precision medicine in intensive and perioperative care. Biomarkers can be used to diagnose, in assessment of disease severity, to stratify risk, to predict and guide clinical decisions, and to guide treatments and response to them. In this review, we will analyze what characteristics a biomarker should have and how to ensure its usefulness, and we will review the biomarkers that in our opinion can make their knowledge more useful to the reader in their clinical practice, with a future perspective. These biomarkers, in our opinion, are lactate, C-Reactive Protein, Troponins T and I, Brain Natriuretic Peptides, Procalcitonin, MR-ProAdrenomedullin and BioAdrenomedullin, Neutrophil/lymphocyte ratio and lymphopenia, Proenkephalin, NefroCheck, Neutrophil gelatinase-associated lipocalin (NGAL), Interleukin 6, Urokinase-type soluble plasminogen activator receptor (suPAR), Presepsin, Pancreatic Stone Protein (PSP), and Dipeptidyl peptidase 3 (DPP3). Finally, we propose an approach to the perioperative evaluation of high-risk patients and critically ill patients in the Intensive Care Unit (ICU) based on biomarkers.

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“…reported a correlation between elevated ESR and poor IPA prognosis ( Tong et al., 2021 ). Procalcitonin, which is predominantly secreted by human thyroid C cells at serum concentrations less than 0.05 ng/mL in healthy individuals ( Xu et al., 2022 ), aids in distinguishing bacterial from nonbacterial infections and diagnosing sepsis ( Gai et al., 2018 ; Downes et al., 2020 ; Pierrakos et al., 2020 ). Although the potential of PCT for diagnosing invasive fungal diseases has been recognized ( Dou et al., 2013 ), its role in invasive aspergillosis remains underexplored and marked by limited and conflicting reports.…”

Section: Introductionmentioning

confidence: 99%

Improved diagnostic markers for invasive pulmonary aspergillosis in COPD patients

Long,

Li,

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundThe prevalence of invasive pulmonary aspergillosis (IPA) among patients with chronic obstructive pulmonary disease (COPD) is steadily increasing, leading to high mortality. Although early diagnosis can significantly reduce mortality, the efficacy of current diagnostic methods is limited. Consequently, there is a need for novel approaches for early IPA detection.MethodsThis retrospective study involved 383 hospitalized COPD patients with GOLD stages III and IV. The IPA group (67 patients) and non-IPA group (316 patients) were identified at the First Affiliated Hospital of Guangzhou Medical University between January 2016 and February 2022. We analyzed common serological indicators in our hospital to identify predictive indicators for the early diagnosis of IPA in COPD patients.ResultsThe sensitivity and specificity of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), lactate dehydrogenase (LDH), and ceruloplasmin (CER) for diagnosing IPA in COPD patients were as follows: CRP (91.2%, 57.7%), ESR (77.5%, 73.0%), PCT (60.5%, 71.4%), LDH (50.0%, 88.8%), and CER (60.7%, 74.3%). Combinations of biomarkers, such as CRP-ESR, CRP-LDH, ESR-LDH, ESR-CER, and LDH-CER, showed promising diagnostic potential, with larger area under the curve (AUC) values for IPA diagnosis in COPD patients. However, no statistically significant difference was observed between the diagnostic efficacy of single biomarkers and combined biomarkers. Notably, compared to those in the unassisted ventilation group, the patients in the assisted ventilation group (including noninvasive ventilation and tracheal intubation/incision-assisted ventilation group) exhibited significantly greater PCT and LDH levels, while the CER significantly decreased (p=0.021). There were no significant differences in biomarker levels between the ICU group and the non-ICU group. CRP (p<0.01), ESR (p=0.028), PCT (p<0.01), and CER (p<0.01) were positively correlated with hospitalization duration, whereas LDH was not correlated with hospitalization duration.ConclusionOur study highlights the diagnostic potential of CRP, ESR, PCT, LDH, and CER for IPA in COPD patients. CRP and LDH can also initially predict the need for assisted ventilation, while CRP can initially estimate the length of hospitalization. This study represents the first report of the potential of CER for diagnosing IPA, suggesting its significance for further research.

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Clinical utility of procalcitonin and its association with pathogenic microorganisms

Cited by 15 publications

References 128 publications

Age, comorbidities, c-reactive protein and procalcitonin as predictors of severity in confirmed COVID-19 patients in the Philippines

Age, comorbidities, c-reactive protein and procalcitonin as predictors of severity in confirmed COVID-19 patients in the Philippines

Biomarkers as Prognostic Predictors and Therapeutic Guide in Critically Ill Patients: Clinical Evidence

Improved diagnostic markers for invasive pulmonary aspergillosis in COPD patients

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