Clinical Value of a One-Stop-Shop Low-Dose Lung Screening Combined with 18F-FDG PET/CT for the Detection of Metastatic Lung Nodules from Colorectal Cancer

Han, Young Jin; Lim, Sungjoon; Jeong, Hwan-Jeong; Sohn, Myung‐Hee

doi:10.1007/s13139-015-0387-4

Cited by 3 publications

(1 citation statement)

References 23 publications

(29 reference statements)

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“…miR-4728-5p expression has been shown to be significantly upregulated in patients with gastric cancer who are positive for HER2, which is overexpressed in gastric cancer and serves as a clinical target for gastric cancer therapy (37,38). miR-708-5p is involved in various processes associated with tumorigenesis and acts as an oncogene in various cancers, including bladder cancer (39,40) and colorectal cancer (41). Taken together, the above-mentioned findings indicate that PART1 plays crucial roles in cancer.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of expression profiles of long non‑coding RNAs with associated ceRNA�network involved in gastric cancer progression

Ren²,

Zheng

et al. 2019

Mol Med Report

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long non-coding rnas (lncrnas) play critical roles in the development and progression of cancers. The present study aimed to identify novel lncrnas and associated micrornas (mirnas or mirs) and mrnas in gastric cancer. differentially expressed lncrnas (delncrnas) and differentially expressed mrnas (demrnas) of 6 paired gastric cancer and normal tissues were identified using microarray. The demirnas between gastric cancer and the normal control tissues were identified using mirna-seq data from cancer Genome atlas. common delncrnas from the cancer rna-Seq nexus database and circlncrnanet database were analyzed. a delncrnas-demirnas-demrnas network was constructed by target prediction. Functional enrichment analysis was employed to predict the function of demrnas in the network. The correlation between the expression of delncrnaS and demrnas in the network was analyzed. The expression levels of several genes were validated by reverse transcription-quantitative polymerase chain reaction (rT-qPcr). a total of 1,297 delncrnas, 2,037 demrnas and 171 DEmiRNAs were identified. Among the 4 lncRNAs common to the 3 datasets, prostate androgen-regulated transcript 1 (ParT1) was selected for further analysis. The analysis identified 5 DEmiRNAs and 13 DEmRNAs in the ParT1-mediated cerna network. The demrnas in the cerna network were markedly enriched in cancer-related biological processes (response to hypoxia, positive regulation of angiogenesis and positive regulation of endothelial cell proliferation) and pathways (cGMP-PKG signaling pathway, caMP signaling pathway and proteoglycans in cancer). out of the 13 demrnas, 11 were positively associated with ParT1. The downregulation of ParT1, myosin light chain 9 (MYl9), potassium calcium-activated channel subfamily M alpha 1 (KcnMa1), cholinergic receptor muscarinic 1 (cHrM1), solute carrier family 25 member 4 (SLC25A4) and ATPase na + /K + transporting subunit alpha 2 (aTP1a2) expression levels in gastric cancer was validated by rT-qPcr. on the whole, the current study identified a novel lncrna and associated mirnas and mrnas that are involved in the pathogenesis of gastric cancer that may serve as potential therapeutic targets for the treatment of gastric cancer.

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