Clinical value of early cleavage embryo

Tsai, Yao‐Chou; Chung, Ming-Ting; Sung, Yung-Yi; Tsai, Tian-Chi; Lin, Liang-Yin

doi:10.1016/s0020-7292(01)00591-4

Cited by 25 publications

(23 citation statements)

References 21 publications

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“…Early cleavage status is one of the most promising new parameters. In previous studies it was found that transferring embryos that had cleaved early led to a significantly higher pregnancy rate (Shoukir et al, 1997;Sakkas et al, 1998Sakkas et al, , 2001Bos-Mikich et al, 2001;Lundin et al, 2001;Fenwick et al, 2002;Tsai et al, 2002) and blastocyst development rate (Fenwick et al, 2002) as compared to non-early cleavage embryos. This is in accordance with the results obtained in the present study (46 versus 18% for pregnancy rate after SET, P , 0.001, and 66 versus 40% for blastocyst rate, P , 0.0001).…”

Section: Discussionmentioning

confidence: 98%

“…The morphological parameters for zygote quality include the number of nucleolar precursor bodies (NPB) and their distribution in the pronuclei (Scott et al, 2000;Tesarik et al, 2000;Wittemer et al, 2000). Early cleavage embryos were defined as those which had cleaved to the 2-cell stage 25-27 h after insemination or ICSI (Shoukir et al, 1997;Sakkas et al, 1998Sakkas et al, , 2001Bos-Mikich et al, 2001;Lundin et al, 2001;Fenwick et al, 2002;Tsai et al, 2002). The conclusion of all these studies was that transfer of early cleavage embryos leads to a higher pregnancy and implantation rate compared to the transfer of non-early cleavage embryos.…”

Section: Introductionmentioning

confidence: 99%

“…As a result, many cycles were included where both early and non-early cleavage embryos were transferred. Therefore it remains uncertain whether the pregnancy or implantation can be attributed to the early cleavage embryo (Shoukir et al, 1997;Sakkas et al, 1998Sakkas et al, , 2001Bos-Mikich et al, 2001;Fenwick et al, 2002;Tsai et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Early cleavage is a valuable addition to existing embryo selection parameters: a study using single embryo transfers

Montfoort¹

2004

Human Reproduction

156

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BACKGROUND: To reduce the twin pregnancy rate, elective single embryo transfer (eSET) is increasingly implemented. Improvement of the results obtained with eSET can be achieved by better selection of the most viable embryo. This study investigated the predictive value of early cleavage (EC) as an additional parameter for selecting the embryo with the highest implantation potential by using data from SET's. METHODS: Data from 165 SET's were retrospectively evaluated. Cleavage to the 2-cell stage was determined 23 -26 h after injection or 25 -28 h after insemination. Selection of the embryo to be transferred was based on cell morphology and cell number on the day of transfer, not on the EC status. Additional information on the predictive value of EC on developmental potential was obtained by analysing 253 transfers with two embryos (double embryo transfer, DET) and blastocyst formation of 1160 surplus embryos. Logistic regression was used to determine the predictors of pregnancy or blastocyst development. RESULTS: A significantly higher pregnancy rate was observed after transfer of single EC embryos compared to single non-EC embryos (46 versus 18%). This result was confirmed by the significantly higher pregnancy rate after DET with two EC embryos as compared to DET with two non-EC embryos (45 versus 25%) and the blastocyst formation of EC embryos compared to non-EC embryos (66 versus 40%). Logistic regression showed that EC is an independent predictor for both pregnancy and blastocyst development in addition to cell morphology and cell number. CONCLUSIONS: In order to improve the selection of the embryo with the highest implantation potential, selection for transfer should not be based on cell number and morphology on the day of transfer alone, but also on early cleavage status.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Early cleavage is a valuable addition to existing embryo selection parameters: a study using single embryo transfers

Montfoort¹

2004

Human Reproduction

156

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“…However, the embryo status at 25 h did not predict affect the percentage of the fragmentation observed later [13]. Although many researchers have considered the connection between early cleavage and embryo morphology [5,12,[14][15][16][17], the early cleavage mechanism is still unknown. The first cell cycle seems to take place when the zygote prepares for the initial cleavage.…”

Section: Discussionmentioning

confidence: 99%

The influence of early cleavage on embryo developmental potential and IVF/ICSI outcome

Wang

et al. 2009

J Assist Reprod Genet

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“…Ovulation induction was performed as reported previously (5). The embryos were transferred on day 3 after OCR.…”

Section: Methodsmentioning

confidence: 99%

Vaginal disinfection with povidone iodine immediately before oocyte retrieval is effective in preventing pelvic abscess formation without compromising the outcome of IVF-ET

Tsai

Lin

Chen

et al. 2005

J Assist Reprod Genet

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Purpose : In this study, the method of employing preretrieval vaginal douching with aqueous povidone iodine is examined to see if it can decrease the incidence of pelvic abscess without compromising the clinical outcome of IVF-ET. Methods : Patients with ovarian endometrioma and received IVF-ET treatment were retrospectively classified into two groups according to the difference of vaginal douching solution immediately before oocyte retrieval. Results : There was no difference in the fertilization rate (81.2% versus 79.8%, P > 0.05), implantation rate (19.2% versus 23.3%, P > 0.05), clinical pregnancy rate (39.3% versus 46.2%, P > 0.05) between the two groups. There was no infection in patients of group two but two cases in group one developed pelvic abscess and needed surgical intervention. Conclusions : Vaginal douching with aqueous povidone iodine followed by normal saline irrigation immediately before oocyte retrieval is effective in preventing the pelvic infection without compromising the outcome of IVF treatment.

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Clinical value of early cleavage embryo

Abstract: Early cleavage embryos possess greater implantation potential. Embryo transfer containing early cleavage embryos had a better clinical pregnancy rate.

Cited by 25 publications

References 21 publications

Early cleavage is a valuable addition to existing embryo selection parameters: a study using single embryo transfers

Early cleavage is a valuable addition to existing embryo selection parameters: a study using single embryo transfers

The influence of early cleavage on embryo developmental potential and IVF/ICSI outcome

Vaginal disinfection with povidone iodine immediately before oocyte retrieval is effective in preventing pelvic abscess formation without compromising the outcome of IVF-ET

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