Clinical value of Leukocyte counts in evaluation of patients with suspected appendicitis in emergency department

Mz, Tamanna; U, Eram; Tm, Al Harbi; Sa, Alrashdi; Su, Khateeb; Sa, Aladhrai; Am, Hussain

doi:10.5505/tjtes.2012.83652

Cited by 12 publications

(8 citation statements)

References 10 publications

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“…Tamanna ve ark. 116 hasta ile yaptıkları çalışmalarında ROC eğrisine göre belirledikleri 10,7x10 3 lökosit sınır değerine göre (AUC; 0,822) sensitivitesi %89,6, spesifitesi %73,5 olarak rapor edilmiş [16]. Zuhoor'un çalışmasında ise daha düşük bir eşik değer saptanmış (9,4x10 3 ; AUC: 0,701) ve bu değere göre sensitivitesi %76,8, spesifitesi %65,5 olarak belirtilmiş [17].…”

Section: Ultrasonografi (Usg)unclassified

Biomarkers in the diagnosis of acute appendicitis

Kapçı¹,

Türkdoğan

Duman³

et al. 2014

J Clin Exp Invest

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Objective: Patients who is presented to ED with the complaint of abdominal pain account an important number in the ED practice. Availability of rapid and inexpensive tests is crucial in the differential diagnosis of these patients. Hemogram parameters is one of them. In this study, we investigated the biomarkers in hemogram parameters of the patients diagnosed with acute appendicitis.Methods: Data of 520 patients who were operated with the presumed diagnosis of appendicitis in our hospital between 01/01/2012 and 31/12/2013 were retrospectively screened. Of the 410 patients whom data were fully reached, leukocyte, neutrophil and lymphocyte counts, neutrophil / lymphocyte ratio (NLR), pathology results and at the admission time and superficial tissue ultrasonography (USG) reports if further investigation has been made were recorded.Results: According to the pathological diagnosis of 334 patients (81.5%), while appendicitis 76 patients (18.5%) was not appendicitis. When taken 11,6 x10 3 for leukocyte, 8.5 x10 3 for neutrophil, 3.9 for NLO, while specificity of total was 78.8%, sensitive 73.6% was found. Conclusion:Together evaluation of neutrophils, lymphocytes and NLR which are routinely used hemogram parameters in association of physical examination is seem to be more appropriate.

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Section: Ultrasonografi (Usg)unclassified

Biomarkers in the diagnosis of acute appendicitis

Kapçı¹,

Türkdoğan

Duman³

et al. 2014

J Clin Exp Invest

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“…According to the literature, WBC and ANC are elevated in 73 to 96% of children with appendicitis, 18 with a sensitivity and specificity for the diagnosis of appendicitis ranging from 55 to 89% and 43 to 66%, respectively. 19,20 This low specificity is due to their frequent presence in many abdominal pain disorders in children. Many of these conditions that require differential diagnosis with appendicitis are more frequent in preschool age than in older children, thus WBC and ANC specificity is even lower in this age group.…”

Section: Discussionmentioning

confidence: 99%

Value of Fibrinogen to Discriminate Appendicitis from Nonspecific Abdominal Pain in Preschool Children

et al. 2019

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Aim The aim of this study was to assess the diagnostic value of the biomarker fibrinogen (FB), along with the markers white blood cell (WBC) count, absolute neutrophil count (ANC), and C-reactive protein (CRP), to discriminate appendicitis from nonspecific abdominal pain (NSAP) in preschool children. Materials and Methods We prospectively evaluated all children aged <5 years admitted for suspected appendicitis at an academic pediatric emergency department during 5 years. Diagnostic accuracy of FB (prothrombin time–derived method), WBC, ANC, and CRP were assessed by the area under the curve (AUC) of the receiver-operating characteristic curve. Results A total of 82 patients were enrolled in the study (27 NSAP, 17 uncomplicated, and 38 complicated appendicitides). WBC and ANC had moderate diagnostic accuracy for appendicitis versus NSAP (WBC: AUC 0.66, ANC: AUC 0.67). CRP and FB had good diagnostic accuracy for appendicitis versus NSAP (CRP: AUC 0.78, FB: AUC 0.77). WBC and ANC are not useful to discriminate complicated versus uncomplicated appendicitis (WBC: AUC 0.43, ANC: AUC 0.45). CPR and FB had good diagnostic accuracy for complicated versus uncomplicated appendicitis (CRP: AUC 0.80, FB: AUC 0.73). Conclusion CRP and FB are more useful than WBC and ANC to discriminate appendicitis from NSAP in preschool children. CRP and FB are especially useful to discriminate complicated from uncomplicated appendicitis and NSAP. In a child with suspected appendicitis, a plasma FB level (prothrombin time–derived method) >540 mg/dL is associated with an increased likelihood of complicated appendicitis.

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“…The leukocyte count increases in case of acute or chronic inflammation as well as acute physical or emotional stress 5 . These tests may serve as guides for advanced imaging techniques.…”

Section: Introductionmentioning

confidence: 99%

Karın Ağrısının Yönetiminde Tomografi ve CRP’nin Önemi

Şimşek¹,

Satar²,

Karasu³

2015

Cukurova Medical Journal

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Purpose: We evaluated whether abdominal tomography is necessary for patients who have been admitted to the emergency service because of non traumatic abdominal pain and effect of C-Reactive Protein (CRP) and tomography to the patient management. Materials and Method: On retrospective study, we recorded demographic data, tomography diagnoses, CRP and leucocyte values operation and following decisions of 199 patient who were 18 years old and over and were admitted to emergency service because of abdominal pain and were scanned abdominal tomography. 104 patient were hospitalized and their CRP values, tomography diagnoses, end of operation diagnoses were recorded from patient files. The statistical analysis was performed using the Chi-square test and the diagnostic value was assessed through the logistic regression test. Results: A statistically significant relationship was observed between anormal tomography findings and high CRP and leukocyte values of the 199 patients included in the study. The tomography findings and CRP values were found to be efficient in discharge and hospitalization rates. When tomography finding and CRP value were combined, the operation decision was effected. Conclusion: Based on our study; in the event of abdominal pain, CRP can predict abnormal tomography finding and it is more valuable than leucocyte. When tomography was used with CRP, it affects the operation decision.

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Clinical value of Leukocyte counts in evaluation of patients with suspected appendicitis in emergency department

Cited by 12 publications

References 10 publications

Biomarkers in the diagnosis of acute appendicitis

Biomarkers in the diagnosis of acute appendicitis

Value of Fibrinogen to Discriminate Appendicitis from Nonspecific Abdominal Pain in Preschool Children

Karın Ağrısının Yönetiminde Tomografi ve CRP’nin Önemi

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