Clinical value of phase and amplitude images and left ventricle time-activity curves in assessing patients with acute myocardial infarction

Abstract

The purpose of this study was to assess the clinical usefulness of phase and amplitude images and of the left ventricle time-activity curve (LVTAC) obtained by equilibrium gated radionuclide ventriculography (EGRV) in patients with acute myocardial infarction (AMI). Fifty-six patients were studied within 4 days of the onset of AMI by EGRV; of these 49 also underwent first-pass (FP) angiocardiography, for comparison with EGRV, and 21 underwent repeated EGRV 3 months after AMI. Phase and amplitude images were obtained by Fourier analysis. LVTAC analysis was performed by a third degree polynomial fitting to determine peak ejection rate (PER) and peak filling rate (PFR). A substantial equivalence of EGRV and FP methods was demonstrated, as regards left ventricle ejection fraction (LVEF), while a sharp superiority of EGRV with Fourier analysis was shown with regard to the sensitivity of RWM abnormality detection. With only one exception all the cases showed RWM abnormalities, while LVEF was normal in 21 of 27 patients with less than three affected segments. The most sensitive global function index was the LVPFR. In the acute phase regional dyskinesis was observed in 14 of 56 patients. About 40% of our cases showed an improvement of the kinetic abnormalities 3 months after AMI. The highest rate of improvement was observed in the group with ECG patterns of limited infarction and with normal LVEF.

Abnormal left ventricular filling in patients with sustained myocardial relaxation: Assessment of diastolic parameters using radionuclide angiography and echocardiography

“…A similar relationship was reported earlier by Bonow et a/. (1981a,b) and Polak et al (1982) and more recently by Picozzi et al (1984). Whether or not this is a manifestation of the Starling mechanism it is impossible to ascertain at this time.…”

The effect of filtrating and reconstruction method on the left ventricular ejection fraction derived from GSPET: a statistical comparison of angiography and echocardiography

“…The left ventricular ejection fraction (LVEF) is an important clinical index for the diagnosis and selection of the treatment procedure in patients with coronary heart disease [1]. There are several modalities for the measurement of the LVEF; however, angiography is the most accurate, albeit invasive method [2,3], and echocardiography is the one most practiced [4,5].…”

Right and Left Ventricular Dysfunction in Inferior Acute Myocardial Infarction

“…Some authors [17][18][19] have already reported a corre lation between right ventricular dysfunction (RVD) and the major, especially haemodynamic, complications ob served during the initial period, but an unanimous agree ment is still lacking [20][21][22], This fact prompted us to evaluate clinically and by equilibrium radionuclide angiography 100 patients with a first transmural inferior AMI with the following aims: (1) to correlate the prevalence of RVD and left ventric ular dysfunction (LVD) with that of each major in-hos pital complication and (2) to identify the major compli cations which most frequently are associated with the others.…”

“…The evaluation of regional wall motion (RWM) of the left ventricle was performed using the functional images of amplitude and phase obtained by Fourier analysis of scintigraphic data. The criteria of amplitude and phase display and interpretation can be found in the literature [20]. The segments defined on left ventricular contour were septal, inferior, and posterolateral in the left anterior oblique view and anterolateral, apical, and inferior in the anterior view.…”

“…The background value was calculated from the end-systolic frame by using the average count per pixel in the area between end-diastolic and end-systolic regions of interest. Our method for the assessment of LVEF and RVEF has been previously validated [11,20]. The evaluation of regional wall motion (RWM) of the left ventricle was performed using the functional images of amplitude and phase obtained by Fourier analysis of scintigraphic data.…”