Clinically Evident, Non-terminal Infections with Herpesviruses and the Wart Virus in Immunosuppressed Renal Allograft Recipients

Warts in a Pediatric Renal Transplant Population

“…This survey confirms that warts are common among renal transplant patients [10,23]. However, in contrast to a report by Spencer and Ander son [23], in which the frequency of warts was directly proportional to time elapsed since transplantation, the frequency in the present study varied from year to year.…”

“…However, in contrast to a report by Spencer and Ander son [23], in which the frequency of warts was directly proportional to time elapsed since transplantation, the frequency in the present study varied from year to year. Half of the patients with post-transplantation warts had had these before transplantation, while all of the patients reported as developing warts by Spencer and Anderson [23] had had them as children or adolescents.…”

“…The frequency of warts among transplant patients is three times that of the general child hood population and twice that of a group of nephrotic pediatric patients who received immunosuppressive therapy. We propose that drug-induced suppression of cell-mediated, and to a lesser extent, humoral immunity, may predispose people to develop warts.Immunosuppressed patients are especially prone to develop viral in fections, including warts [10,23], After several patients in the Children's Hospital Medical Center renal transplant program developed large, aggres sive, persistent warts, we examined all renal transplant recipients for the presence of warts. …”

Epidermodysplasia-Verruciformis-Like Eruption Associated with Gamma-Papillomavirus Infection in a Patient with Adult T-Cell Leukemia

“…Immunosuppressed patients manifest a marked increase in the incidence of viral warts [42,43,44,45,46,47]. Although in most cases clinical and histological features of the warts [17,42,43,46,47,48] and the associated HPV types [17,46,48] in immunosuppressed patients do not differ from those in the general population, rare cases of acquired EV-like eruption have been reported in immunosuppressed patients, including patients with organ transplants [15,16,17,18,19], lepromatous leprosy [49], Hodgkin lymphoma [20], systemic lupus erythematosus [21,22], human immunodeficiency virus infection [19,23,24,25,26,27,28,29,30,31,32,33,34,50,51], severe combined immune deficiency caused by γc or JAK3 deficiency after hemopoietic stem cell transplantation [35], and in the setting of graft-versus-host disease [36].…”

Dyskeratosis congenita with Epidermodysplasia verruciformis of Lewandowsky and Lutz

“…This complication is associated with an absence of delayed hypersensitivity to inactivated vaccinia virus [8], While in the past little attention has been paid to warts in patients with anergy, in recent years persistent and extensive verrucosis has been described in association with disorders which impair the immune system (leukaemia, etc.) [19,24], Warts, for instance, are common in Hodgkin's disease and may smother the skin of these patients [15,23], Warts have also been specifi cally mentioned in Wiskott-Aldrich syndrome and in some types of dysgammaglobulinemia [5], So, it would seem to be of interest to report a case in which Zinsser-ColeEngmann syndrome with a severe blood dyscrasia was associated with epidermodysplasia verruciformis of Lewandowsky and Lutz. Apart from being, to the best of our knowledge, the first published report of this associa tion, we think this case to be of interest in the context of pathogenesis.…”