Clinically relevant effects of Mindfulness-Based Stress Reduction in individuals with asthma

Higgins, Estelle T.; Davidson, Richard J.; Busse, William W.; Klaus, Danika R.; Bednarek, Gina T.; Goldman, Robin I.; Sachs, Jane; Rosenkranz, Melissa A.

doi:10.1016/j.bbih.2022.100509

Cited by 10 publications

(3 citation statements)

References 95 publications

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“…This negative impact on mental health could impact other autoimmune and inflammatory diseases. Psychological stressors are associated with worsening symptoms of diseases such as asthma and atopic dermatitis 29–32 . The relationship between AA and mental health conditions is complex and may be related to the underlying immunoinflammatory pathophysiology, increased risk from other autoimmune and atopic comorbidities, associated genetic risk components, and psychosocial effects.…”

Section: Discussionmentioning

confidence: 99%

“…Psychological stressors are associated with worsening symptoms of diseases such as asthma and atopic dermatitis. [29][30][31][32] The relationship between AA and mental health conditions is complex and may be related to the underlying immunoinflammatory pathophysiology, increased risk from other autoimmune and atopic comorbidities, associated genetic risk components, and psychosocial effects. Further research is needed to elucidate the relationships between these factors.…”

Section: Autoimmune or Atopic Conditionmentioning

confidence: 99%

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Prevalence of autoimmune and inflammatory diseases and mental health conditions among an alopecia areata cohort from a US administrative claims database

George

Jagun

Liu

et al. 2023

The Journal of Dermatology

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Alopecia areata (AA) is associated with an increased burden of autoimmune and inflammatory disease and mental health conditions that may have a negative impact on quality of life. However, the exact burden of comorbidities on US patients with AA and the clinical subtypes alopecia totalis (AT) and alopecia universalis (AU) compared with those without AA is not well understood. This retrospective cohort study aimed to assess the incidence rates and prevalence of AA and its clinical subtypes and examine the autoimmune and inflammatory disease and mental health condition diagnosis burden in US patients with AA and a matched cohort without AA. The Optum Clinformatics Data Mart database was used to select patients aged ≥12 years enrolled between October 1, 2016, and September 30, 2020, who had two or more AA diagnosis codes for the AA cohort. Three patients without AA were age‐, sex‐, and race‐matched to each patient with AA. Autoimmune and inflammatory diseases and mental health conditions were evaluated at baseline and up to 2 years after the index date. In total, 8784 patients with AA (599 with AT/AU) and 26 352 matched patients without AA were included. The incidence rate of AA was 17.5 per 100 000 person‐years (PY; AT/AU: 1.1 per 100 000 PY; non‐AT/AU: 16.3 per 100 000 PY), and the prevalence was 54.9 per 100 000 persons (AT/AU: 3.8; non‐AT/AU: 51.2). Patients with AA had a higher prevalence of autoimmune and inflammatory diseases than the matched non‐AA cohort, including allergic rhinitis (24.0% vs 14.5%), asthma (12.8% vs 8.8%), atopic dermatitis (8.3% vs 1.8%), and psoriasis (5.0% vs. 1.6%). The proportions of anxiety (30.7% vs 21.6%) and major depressive disorder (17.5% vs 14.0%) were higher in patients with AA than those without AA. Patients with AT/AU generally had a greater prevalence of autoimmune and inflammatory disease and mental health conditions than patients with non‐AT/AU AA.

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Section: Discussionmentioning

confidence: 99%

Section: Autoimmune or Atopic Conditionmentioning

confidence: 99%

Prevalence of autoimmune and inflammatory diseases and mental health conditions among an alopecia areata cohort from a US administrative claims database

George

Jagun

Liu

et al. 2023

The Journal of Dermatology

View full text Add to dashboard Cite

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“…The aims and findings of the larger clinical trial are beyond the scope of the current report, but, in brief, sought to test the efficacy of MBSR on change in 3 main outcomes: functional neurodynamics of emotional responses, diurnal cortisol, and lung function (in participants with asthma). To date, the study team has published positive findings with regards to the third outcome, whereby MBSR was associated with improved asthma control and reduced levels of exhaled nitric oxide 33 . This study was conducted entirely at the Center for Healthy Minds at the University of Wisconsin–Madison, and with the affiliated non-profit organization, Healthy Minds Innovations (HMI).…”

Section: Methodsmentioning

confidence: 99%

Slower respiration rate is associated with higher self-reported well-being after wellness training

Kral,

Weng,

Mitra

et al. 2023

Sci Rep

Self Cite

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Mind–body interventions such as mindfulness-based stress reduction (MBSR) may improve well-being by increasing awareness and regulation of physiological and cognitive states. However, it is unclear how practice may alter long-term, baseline physiological processes, and whether these changes reflect improved well-being. Using respiration rate (RR), which can be sensitive to effects of meditation, and 3 aspects of self-reported well-being (psychological well-being [PWB], distress, and medical symptoms), we tested pre-registered hypotheses that: (1) Lower baseline RR (in a resting, non-meditative state) would be a physiological marker associated with well-being, (2) MBSR would decrease RR, and (3) Training-related decreases in RR would be associated with improved well-being. We recruited 245 adults (age range = 18–65, M = 42.4): experienced meditators (n = 42), and meditation-naïve participants randomized to MBSR (n = 72), active control (n = 41), or waitlist control (n = 66). Data were collected at pre-randomization, post-intervention (or waiting), and long-term follow-up. Lower baseline RR was associated with lower psychological distress among long-term meditators (p* = 0.03, b = 0.02, 95% CI [0.01, 0.03]), though not in non-meditators prior to training. MBSR decreased RR compared to waitlist (p = 0.02, Cohen’s d = − 0.41, 95% CI [− 0.78, − 0.06]), but not the active control. Decreased RR related to decreased medical symptoms, across all participants (p* = 0.02, b = 0.57, 95% CI [0.15, 0.98]). Post-training, lower RR was associated with higher PWB across training groups compared to waitlist (p* = 0.01, b = 0.06, 95% CI [0.02, 0.10]), though there were no significant differences in change in PWB between groups. This physiological marker may indicate higher physical and/or psychological well-being in those who engage in wellness practices.

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Brain–Airway Interactions in Asthma

Busse

Bartels

Rosenkranz

2023

Advances in Experimental Medicine and Biology

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Clinically relevant effects of Mindfulness-Based Stress Reduction in individuals with asthma

Cited by 10 publications

References 95 publications

Prevalence of autoimmune and inflammatory diseases and mental health conditions among an alopecia areata cohort from a US administrative claims database

Prevalence of autoimmune and inflammatory diseases and mental health conditions among an alopecia areata cohort from a US administrative claims database

Slower respiration rate is associated with higher self-reported well-being after wellness training

Brain–Airway Interactions in Asthma

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