Clinically significant anxiety as a risk factor for dementia in the elderly community

Santabárbara, Javier; López-Antón, Raúl; Cámara, Concepción de la; Lobo, Elena; Gracia-García, Patricia; Villagrasa, Beatriz; Bueno-Notivol, Juan; Marcos, Guillermo; Lobo, Antonio

doi:10.1111/acps.12966

Cited by 42 publications

(55 citation statements)

References 54 publications

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“…Besides, old age and less education could contribute to cognitive impairment in the MT group. Similarly, the interaction between cognition and mental disorders may also lead to such inter‐group differences 28 …”

Section: Discussionmentioning

confidence: 99%

Non‐motor symptoms are associated with midline tremor in essential tremor

et al. 2020

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including cognition deficiency, psychiatry symptoms, sleep disruption, and sensory abnormalities, has recently been reported in ET syndrome. 2 Besides, accumulating evidence on different etiologies, pathophysiologies, and clinical features has demonstrated the heterogeneity of ET syndrome, even giving rise to a new placeholder, ET-plus. 2,3 Due to such heterogeneity, its disease sub-types should be extensively studied to understand the inherent mechanisms of ET syndrome.

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Section: Discussionmentioning

confidence: 99%

Non‐motor symptoms are associated with midline tremor in essential tremor

et al. 2020

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“…The Fine and Gray's model benefits from the use of the inclusion of the actual mortality data to study the usage of methamphetamine as a risk factor for dementia. 44,45 The difference in the risk of dementia, between the study and control groups, was estimated using the Kaplan-Meier method with the log-rank test. A 2-tailed P value < 0.05 was considered to indicate statistical significance.…”

Section: Discussionmentioning

confidence: 99%

Association between amphetamine‐related disorders and dementia‐a nationwide cohort study in Taiwan

Tzeng

Chien

Chung

et al. 2020

Ann Clin Transl Neurol

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Objective We have conducted a study to clarify the association between amphetamine‐related disorders (ARD) and the risk of developing dementia. Methods This study used a retrospective cohort design by using Taiwan’s National Health Research Institute Database. A random sample of 68,300 subjects between January 1, 2000, and December 31, 2015, was obtained, comprising of 17,075 patients with ARD, and 51,225 controls without ARD (1:3), matched for gender and age group. After adjusting for covariates, a Fine and Gray’s survival analysis (competing with mortality) was used to compare the risk of dementia during a 15‐year follow‐up period. Results In the present study, 1,751 of 17,075 patients with ARD and 2,147 of 51,225 in the control group without ARD (883.10 vs 342.83 per 100,000 person‐years) developed dementia. ARD cohort was more likely to develop dementia (hazard ratio = 4.936 [95% CI: 4.609–5.285, P < 0.001). After adjusting for gender, age groups, education, monthly insured premiums, urbanization level, geographic region, comorbidities, the hazard ratio for ARD patients was 5.034 (95% CI: 4.701–5.391, P < 0.001). ARD has been associated with overall dementia, Alzheimer dementia, vascular dementia, and other dementia. Both the amphetamine use disorder and amphetamine‐induced psychotic disorders were associated with the risk of overall dementia, Alzheimer dementia, vascular dementia, and other dementia. Interpretation This study shows that patients with ARD, both the amphetamine use disorder and the amphetamine‐induced psychotic disorder, may have a nearly fivefold risk of developing dementia, including Alzheimer dementia and other types of dementia.

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“…The following covariates were used: socio-demographic characteristics (age, sex, educational level, marital status and living alone), medical risk factors (vascular disease, hypertension and diabetes), health status, cognitive status and clinically significant depression. (Santabárbara et al, 2018) A…”

Section: Covariatesmentioning

confidence: 99%

“…Since we have shown that clinically relevant anxiety increases the risk of overall dementia (Santabárbara et al, 2018), we now hypothesize that it also is associated with increased AD risk. A second objective was to report the population-attributable fraction (PAF) of AD due to anxiety disorder.…”

Section: Introductionmentioning

confidence: 95%

Clinically relevant anxiety and risk of Alzheimer's disease in an elderly community sample: 4.5 years of follow-up.

Santabárbara¹,

Villagrasa

López-Antón

et al. 2019

Journal of Affective Disorders

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The risk of Alzheimer's disease was almost 4-fold higher in cases of clinically relevant anxiety compared with non-cases, even when controlling for depression and other potential confounders. This finding may stimulate future studies to test the impact of the treatment of anxiety on prevention or delay onset of symptoms of AD. The association between subcases of anxiety at baseline and AD risk did not reach statistical significance.

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Clinically significant anxiety as a risk factor for dementia in the elderly community

Cited by 42 publications

References 54 publications

Non‐motor symptoms are associated with midline tremor in essential tremor

Non‐motor symptoms are associated with midline tremor in essential tremor

Association between amphetamine‐related disorders and dementia‐a nationwide cohort study in Taiwan

Clinically relevant anxiety and risk of Alzheimer's disease in an elderly community sample: 4.5 years of follow-up.

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