Clinician engagement is critical to public engagement with clinical trials

Stock, Christopher; Carley, Nick; Hickman, Ben; Primrose, John; Ayres, Alison; McGrath, Christine J.; Edwards, Christopher J; Faust, Saul N

doi:10.1136/bmj.h3140

Cited by 7 publications

(6 citation statements)

References 1 publication

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“…Enrolment as part of routine care is also supported by a recent survey showing that NHS patients are more likely to participate in research if the topic is introduced by the potential research participant's own doctor. 93 The qualitative study also provided clear advice regarding the need to approach parents at times other than 'pinch points' of anxiety/distress if at all possible, and regarding the need for a clear explanation of potential risk and safety aspects.…”

Section: Logistics Of a Clinical Trial Including Criteria For Oral Swmentioning

confidence: 99%

Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study

Sukhtankar

Arch

Ahmad

et al. 2017

Health Technol Assess

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Declared competing interests of authors: Saul N Faust was UK chief investigator and University Hospital Southampton NHS Foundation Trust principal investigator for a Cubist-sponsored clinical trial of daptomycin against standard of care antibiotic therapy in paediatric osteomyelitis. All funds were paid into accounts within the NHS trust or university and not paid as personal fees. He reports consultancy fees for advisory board participation paid into accounts within the NHS trust or university (not personal fees) from vaccine manufacturers and antimicrobial agent manufacturers, including AstraZeneca, Cubist, Merck, GlaxoSmithKline (GSK) and Pfizer, outside the submitted work. He acts as principal investigator for clinical trials and other studies conducted on behalf of University Hospital Southampton NHS Foundation Trust/ University of Southampton that are sponsored by vaccine manufacturers and antimicrobial agents, and has participated in advisory boards for vaccine manufacturers. Adam Finn reports grants and personal fees from Sanofi Pasteur MSD Ltd (SPMSD), and grants and personal fees from GSK, outside the submitted work. In addition, prior to October 2014, the University of Bristol and University Hospitals Bristol NHS Foundation Trust received funding for research conducted by Adam Finn and for consultancy and lectures from Pfizer, GSK, SPMSD and Novartis, who manufacture licensed and developmental meningococcal vaccines. Stuart C Clarke acts as principal investigator for clinical trials and other studies conducted on behalf of University Hospital Southampton NHS Foundation Trust/University of Southampton that are sponsored by vaccine manufacturers but receive no personal payments from them. He has participated in advisory boards for vaccine manufacturers and has received financial assistance from vaccine manufacturers to attend conferences, but receives no personal payments for this work. All grants and honoraria are paid into accounts within the respective NHS trusts or universities. Jethro Herberg reports that he was an investigator for a Cubist-sponsored clinical trial of daptomycin against standard of care antibiotic therapy in paediatric osteomyelitis; he received no personal payments. Andrew Riordan reports that the trust, but not he, has received funding for research sponsored by vaccine manufacturers and antimicrobial agents. He was lead editor for an e-learning package on meningitis produced by the Royal College of Paediatric and Child Health, funded by an unrestricted grant from Novartis Vaccines. Marieke Emonts was Newcastle upon Tyne Hospitals Foundation Trust's principal investigator for a Cubist-sponsored clinical trial of daptomycin against standard of care antibiotic therapy in paediatric osteomyelitis. All grants and honoraria are paid into accounts within the NHS trust or university; she received no personal payment of any kind. Marieke Emonts reports acting as site principle investigator on behalf of the Newcastle upon Tyne Hospitals Foundation Trust/Newcastle University for clinical tr...

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Section: Logistics Of a Clinical Trial Including Criteria For Oral Swmentioning

confidence: 99%

Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study

Sukhtankar

Arch

Ahmad

et al. 2017

Health Technol Assess

View full text Add to dashboard Cite

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“…7 , 8 As the volume of clinical research activity within clinical care settings increases, health care professionals are expected to play a larger role in identifying and assisting patient participants. 9 …”

Section: Introductionmentioning

confidence: 99%

Global Public Attitudes About Clinical Research and Patient Experiences With Clinical Trials

Anderson¹,

Borfitz²,

Getz

2018

JAMA Netw Open

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“…Encouragingly, almost a quarter of pregnant women would consider taking part in a hypothetical GBS clinical trial and healthcare professionals were also supportive in that they would be willing to provide significant practical help to the study teams. The involvement of the patient's own clinician is particularly important in optimizing participation , although our previous qualitative work has suggested that some maternity professionals may be very ambivalent about clinical vaccine trials . It is reassuring that these were not the views of this more representative sample of UK maternity professionals and suggests that recruiting local staff to be part of the study team could be key to success.…”

Section: Discussionmentioning

confidence: 88%

Antenatal vaccination against Group B streptococcus: attitudes of pregnant women and healthcare professionals in the UK towards participation in clinical trials and routine implementation

McQuaid

Jones

Stevens

et al. 2018

Acta Obstet Gynecol Scand

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Clinician engagement is critical to public engagement with clinical trials

Cited by 7 publications

References 1 publication

Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study

Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study

Global Public Attitudes About Clinical Research and Patient Experiences With Clinical Trials

Antenatal vaccination against Group B streptococcus: attitudes of pregnant women and healthcare professionals in the UK towards participation in clinical trials and routine implementation

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