Clinico-demographic profile of hyperbilirubinemia in neonates admitted to a tertiary care hospital

Abstract

Background: The purpose of this study was to find etiological and other associated factors of neonatal hyperbilirubinemia at a tertiary care hospital SGRRIM&HS Patel Nagar Dehradun Uttrakhand, India. Jaundice is a common problem in neonatology. Early recognition of the cause of jaundice is very important as delay in management may lead to serious complications or even death. Methods: In present study, newborns with jaundice were evaluated during a 12 months period between January 2015-December 2015. 195 newborns with jaundice were enrolled in the study. Data regarding demographic profile of new born, physical examination and laboratory investigations were gathered and analyzed to interpret the common etiologies giving rise to neonatal hyperbilirubinemia. Results: Out of 195 cases of neonatal hyperbilirubinem, 40 cases belonged to physiological jaundice. Breast feeding jaundice-121 cases, breast milk jaundice-5 cases, jaundice due to prematurity-8 cases and pathological jaundice-21 cases (6 were of ABO incompatibility, 4 neonatal sepses, 4 Rh incompatibility, 4 G6PD deficiencies, 2 neonatal hypothyroidism and 1 congenital biliary atresia). Conclusions: Present study concludes that breast feeding jaundice forms the bulk of cases of neonatal hyperbilirubinemia in our hospital, followed by physiological jaundice, jaundice of prematurity, ABO Incompatibility, breast milk jaundice, neonatal sepsis, Rh incompatibility, G6PD Deficiency, neonatal hypothyroidism and congenital biliary atresia.

Clinico-etiological profile of neonates admitted with jaundice in a tertiary care NICU of Central India

“…Some of the common causes of neonatal jaundice include physiological jaundice, breast feeding or non-feeding jaundice, breast milk jaundice, prematurity leading to jaundice and various pathological causes like hemolytic disease, liver dysfunction, neonatal sepsis, deficiency of glucose-6-phosphatase (G6PD) enzyme, Rh-incompatibility, hypothyroidism and rare conditions such as Gilbert's syndrome, Crigler-Najjar syndrome etc. 4 The present study was conducted to assess the clinic-etiological profile of neonates admitted with jaundice in our NICU and to compare the result with current published national and international data.…”