Clinico-Laboratory Profile and Immediate Outcomes of Hyperbilirubinemic Babies Admitted in Kanti Children Hospital

Nepal, Deepeshwara; Banstola, Dinesh; Khakal, Ajaya Kumar; Mishra, Udbhabhat; Maheseth, Chandeshawar

doi:10.3126/jnps.v30i1.2457

Cited by 8 publications

(10 citation statements)

References 12 publications

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“…Among half of the cases (52.4%) range of serum total bilirubun was found between 15 and 19.9 mg/dl. Same results were observed in the study of Nepal D et al 5 . They mentioned that maximum number (67.1%) of infants' peak serum bilirubin fell in the range of 15-19.9 mg/dl.…”

Section: Results and Observationsupporting

confidence: 77%

“…Pre-term and low birth weight babies were having higher levels of serum total bilirubin but the difference was not significant (P>0.05) ( In our study out of 63, 40(62%) cases were diagnosed as having physiological jaundice by while others were having ABO incompatibility (15%), Rh incompatibility(8%), septicemia(12%) and G-6 PD deficiency(3%). In the study of Nepal D et al 5 they noted that clinical sepsis as defined by WHO criteria was found in 86.3% of babies. Nearly 1/3rd (32.9%) babies were ABO incompatible and 4.1% babies were Rh incompatible.…”

Section: Results and Observationmentioning

confidence: 99%

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Study of Hematological Parameters Among Neonates Admitted With Neonatal Jaundice

Shah¹,

C²,

Shah³

2012

jemds

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Section: Results and Observationsupporting

confidence: 77%

Section: Results and Observationmentioning

confidence: 99%

Study of Hematological Parameters Among Neonates Admitted With Neonatal Jaundice

Shah¹,

C²,

Shah³

2012

jemds

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“…Among half of cases range of serum total bilirubin was found between 14-18 mg/dl. Same results were observed in the study of Nepal D et al [8] . They mentioned that maximum number of infants' peak total serum bilirubin fall in the range of 15-19.…”

Section: Laboratory Parameterssupporting

confidence: 87%

Study of immunohematological and biochemical parameters in neonatal jaundice at tertiary care centre

Sagathia¹,

Shah²,

Goswami³

2021

Int. J. Clin. Diagn. Pathol.

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Introduction: Jaundice is most common problem faced by neonates in the first week of life. Although physiological jaundice is more frequent as compared to pathological jaundice, so it is very important to differentiate between the two as pathological jaundice may lead to kernicterus and subsequently brain damage. There are various modalities of investigations for diagnosis of jaundice e.g. complete blood count, Total serum bilirubin, Blood group, Direct and Indirect coomb's test, G-6PD deficiency etc. by which we can reach at diagnosis. Treatment is also dependent upon the amount of total serum bilirubin and various other laboratory investigations. Thus laboratory workup is very important for diagnosis, prevention of neonatal hyperbilirubinemia and its complications. With this background present study was conducted for the analysis of clinicopathological profile among infants with neonatal hyperbilirubinemia. Aims and Objectives: The current study was planned to assess the hematological profile of neonatal jaundice and to categorize it on the basis of causes and severity. Materials and Methods: The present study conducted on 140 neonates admitted in NICU, at tertiary care centre, Ahmedabad; during first week of life along with total serum bilirubin level greater than 5 mg/dl. Peripheral blood was drawn from all study subjects under aseptic precautions and study done for Total Serum bilirubin, Direct and indirect coomb's test, Blood group, G-6PD deficiency, complete blood count and CRP. Results: In our study among 140 cases with neonatal jaundice, Total number of Pre-term babies (< 37 weeks) was 91 (65%). Most of the neonates were present with jaundice at the age of 2-4 days. Physiological jaundice constituted majority in 95 cases (67%). ABO incompatibility was the commonest cause of pathological jaundice followed by septicemia. The rise in total serum bilirubin level was found to be more in pathological jaundice as compare to physiological jaundice.

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“…Male newborns had more risk of jaundice, in studies by Mantani et al, Sharma et al and Maisal et al [15][16][17] . The serum bilirubin levels and weight of the newborn had no correlation but in the studies by Nepal D et al (19.2%) and Chaudhary et al (42%) observed significance with weight of the newborn (SGA) [18][19] . The mean age of presentation was 3.74 ± 2.34 days.…”

Section: Discussionmentioning

confidence: 99%

Factors affecting the severity of hemolytic disease of the new-born due to ABO incompatibility

Mendapara¹,

Makwana²

2021

Int. J. Paediatrics Geriatrics

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Background and Aim: ABO incompatibility is one of the most common cause of hemolytic disease of fetus and new born. Better understanding of the factors affecting its severity helps to optimise care. The objective of this study was to investigate the factors affecting the severity of HDN due ABO incompatibility in new-borns. Methods: This study was a prospective observational study conducted in the NICU, department of Pediatrics, P.D.U Government Medical College and Hospital, Rajkot. The study was conducted from January 2019 to June 2019; 50 new-borns with ABO incompatibility i.e., having blood group A or B born to mothers with blood group O, presenting with jaundice and or anemia were enrolled in the study. Various maternal and neonatal factors and their possible association in affecting the severity of HDN were studied. Results: In our study, 27 neonates (54%) were male and 23 neonates (46%) were female. Percentage of O-A and O-B incompatible neonates were 26 (52%) and 24 (48%) respectively. The various maternal and neonatal factors had no significant association in affecting the severity of the disease. The mean age of presentation was 3.74 ± 2.34 days. Jaundice was detected in the first 24 hours of life in 6% neonates. The mean initial indirect bilirubin was 19.77 ± 2.50, and initial hemoglobin was 14.41 ± 2.07. Ten neonates (20%) had anemia. Total of 15 neonates (30%) had evidence of hemolysis in the form of spherocytosis. Direct Coombs Test was positive in one case. The mean duration of phototherapy was 54.62 ± 5.79 hours. Three neonates (6%) required exchange transfusion and 4 neonates (8%) received IVIG. The mean duration of stay was 4.18 ± 1.04 days. Conclusion:Although none of the factors had a significant association in affecting the severity of HDN due to ABO incompatibility, we should remember that ABO incompatibility is not always a benign condition and should be considered even in those with a negative DCT. Early identification of high-risk neonates with ABO incompatibility and prompt diagnosis and treatment can reduce morbidity and mortality.

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Clinico-Laboratory Profile and Immediate Outcomes of Hyperbilirubinemic Babies Admitted in Kanti Children Hospital

Cited by 8 publications

References 12 publications

Study of Hematological Parameters Among Neonates Admitted With Neonatal Jaundice

Study of Hematological Parameters Among Neonates Admitted With Neonatal Jaundice

Study of immunohematological and biochemical parameters in neonatal jaundice at tertiary care centre

Factors affecting the severity of hemolytic disease of the new-born due to ABO incompatibility

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