Background: Most of the neonates frequently have jaundice which is very often physiologic jaundice due to the immaturity of the liver and is universal and resolves within first ten days of life. The other is the more ominous pathological jaundice. Aim of the study: To study the clinical profile and etiology of neonatal jaundice Materials and Methods: This was a prospective study. A total of 73 cases of neonates with jaundice were admitted in the study period. The patient demographics such as age and gender, detailed clinical history, relevant laboratory investigations, and the etiology of jaundice were noted. Results: There were 39 (53.4%) male and 34 (46.5%) female newborns and the male to female ratio was 1.1:1. There were 79.4% term deliveries and 20.5% preterm deliveries. There were 68.4% cases with normal birth weight and 31.5% were low birth weight newborns. Physiological jaundice was seen in 76.7% (56) cases and pathological jaundice was seen in 23.2% (17) cases. ABO and Rh incompatibility, and neonatal sepsis were common causes for pathologic jaundice. Conclusion: Neonatal jaundice is a common clinical problem that requires to be categorized as physiological or pathological type. It has to be addressed at the earliest so as to prevent irreversible kernicterus. ABO and Rh incompatibility, neonatal sepsis, low birth weight and prematurity are associated with neonatal jaundice. Education of expectant mothers and community in general will help to reduce the severity and burden of neonatal jaundice.