Clinico-Pathological Profile of Liver Abscess in a Teaching Hospital

Siddiqui, MN; Ahad, MA; Ekram, Arm Saifuddin; Islam, QT; Hoque, Monjurul; Masum, Qaai

doi:10.3329/taj.v21i1.3218

Cited by 10 publications

(23 citation statements)

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“…Pleural effusion was seen in 12% (n=6) cases whereas ascites was observed in 6% cases. Similar finding was reported by Siddiqui et al 8 Other complications like sepsis, multi-organ dysfunction and death were not seen in present study which could be attributed to the early diagnosis with prompt and aggressive treatment of the disease. Another reason being the smaller number of sample size of present study.…”

Section: 7supporting

confidence: 79%

“…Hence the differentiation is essential for effective treatment. 8 In this article, we present the study of clinical, lab parameters and management of suspected Department of Medicine, Hamdard Institute of Medical Sciences and Research and Hakeem Abdul Hameed Centenary Hospital, New Delhi, India liver abscess patients, so that an early diagnosis can be made and prompt treatment can be started and complications can be prevented.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and biochemical profile of liver abscess patients

et al. 2017

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Background: Liver comprises 48% of all the visceral abscesses. It is common in India with 2nd highest incidence due to poor sanitation, overcrowding and inadequate nutrition. Worldwide, approximately 40-50 million people are infected annually with amoebic abscesses. This study aims to observe the clinical and biochemical profile of liver abscess patients so that a prompt diagnosis can be made and early treatment can be given.Methods: The study was conducted over a period of 1 year on 50 patients of liver abscess. History and physical examination was done. All patients were subjected to complete hemogram, liver function test, coagulation profile (PT/INR) and USG abdomen. Serology for Entamoeba histolytica and HIV was done.Results: The mean age of the patients was 41.8 years with male preponderance. Amoebic liver abscess (86%) was predominant over pyogenic liver abscess (14%). Alcoholism (52%) and diabetes mellitus (20%) are main predisposing factors in case of liver abscess. Hepatomegaly was found in 80% cases. Elevated ALP, low albumin, increased PT INR points to the diagnosis of liver abscess. The abscesses were predominantly in right lobe (76%) and solitary (66%). Complications seen were ascites (12%) and pleural effusion (6%).Conclusions: Liver abscess should be suspected in patients presenting with prolonged fever and pain upper abdomen specially if patient is alcoholic or has diabetes mellitus. Ultrasonography is an easy and cost effective investigation to diagnose liver abscess. Early and aggressive treatment is the mainstay to prevent complications, morbidity and mortality.

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Section: 7supporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Clinical and biochemical profile of liver abscess patients

et al. 2017

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“…8 Siddiqui et al reported that according to USG report 70% patients were having single abscess and the rest 30% had multiple abscesses. 6 This pattern of involvement has also been reported in previous series on ALA by Sharma et al, Mukhopadhyay et al and Ghosh et al [10][11][12] In present study, chest X-ray abnormality was more in PLA (50%) compared to ALA group (35.8%). Reports of Choudhary et al reported that chest X-ray finding were abnormal in 39% of cases and was comparable to present study findings.…”

Section: Discussionsupporting

confidence: 75%

“…4 Most of the patients in present study with liver abscess were in middle age with patients in second to fourth decade accounting for55.2% of the cases which is comparable to other study done by Grorgia et al 5 Siddiqui et al reported that in case of ALA most common age group was 31-40 and in group of PLA 41-50 age group was more affected. 6 In our study there was high incidence of liver abscess in males (77.61%), as seen in a study by Huang et al (96%). A similar study done by Choudhary et al also reported similar age group (30-60 years) in liver abscess patients with male preponderance (72%).…”

Section: Discussionsupporting

confidence: 74%

A prospective study of ultra-sonographic and radiological profile of patients with liver abscess

Tirkey¹,

Jah²

2018

jmscr

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“…A few investigators documented some sociodemographic aspects of these patients attended at RMCH, however, spectra of morbidity and mortality of ALA were not reported in those studies [9, 10]. More over, precise geographical distribution of ALA cases in the northern areas was not recorded by any investigator.…”

Section: Introductionmentioning

confidence: 99%

Amebic liver abscess in northern region of Bangladesh: sociodemographic determinants and clinical outcomes

et al. 2014

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BackgroundAmebic liver abscess (ALA) is endemic in Bangladesh since historical age but its epidemiology and sociodemographic determinants are not well described in the literatures. This paper focuses on the endemicity, sociodemographic determinants and clinical outcomes of ALA patients from certain northern districts in Bangladesh. Ninety hospitalized ALA patients enrolled from 6 northern districts of Bangladesh during July 2008 to June 2010 were analyzed.FindingsClinical presentations of ALA was initially substantiated by ultrasound imaging and later confirmed by detection of small subunit rRNA gene of E. histolytica using a Real Time PCR. Structured questionnaire and data sheet were used to record sociodemographic characteristics, clinical presentations and outcomes. Patients were followed for immediate and late treatment outcomes up to 2 years since diagnosis. Northern districts those situated on the Ganges basin were noted as endemic areas. Male significantly outnumbered the female with a male to female ratio of 21:1 and majority of patients (58%) were in their 3rd and 4th decades. A significant (21%) number of patients were aborigines despite their ethnic minority as population under investigation and overall 68% belonged to low socioeconomic group. Habit of indigenous alcohol consumption was very high (78%) among ALA patients with overwhelming majority was illiterate (74.44%) and from rural population (70%). Fever with right hypochondriac pain of variable duration was the principal presenting complains. Gross fluid derangements including pleural effusion, edema and ascities were observed in 39% cases and 6% had rupture of abscess. All patients were treated with standard antimicrobial regimen and discharged with initial recovery. Recurrent attack was observed in 6% cases and 3 (3.33%) patients died during 2 years follow-up period. Complicated (37.78%) ALA patients showed significant Odds ratio (P < 0.05) for major sociodemographic determinants in comparison to non-complicated patients.ConclusionsAmebic liver abscess is endemic in certain northern districts of Bangladesh especially on the Ganges basin with relatively high prevalence among aborigines. Rural habitat, ethnicity (Aborigine) and habit of indigenous alcohol consumption were found to be strong determinants, especially for complicated ALA, which were associated with different grades of morbidity and a few mortalities.

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Clinico-Pathological Profile of Liver Abscess in a Teaching Hospital

Cited by 10 publications

References 10 publications

Clinical and biochemical profile of liver abscess patients

Clinical and biochemical profile of liver abscess patients

A prospective study of ultra-sonographic and radiological profile of patients with liver abscess

Amebic liver abscess in northern region of Bangladesh: sociodemographic determinants and clinical outcomes

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