Clinico-pathological study of Fallopian tubes after transcervical insertion of quinacrine hydrochloride pellets

Merchant, R. N.; Doctor, Vatsala M.; Thaku, S S; Sinha, Manish Kumar; Jhaveri, C L; Kessel, E; Mumford, Stephen

doi:10.1007/bf01849300

Cited by 16 publications

(12 citation statements)

References 6 publications

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“…A prehysterectomy study of Merchant and her co-workers [23] demonstrated that longer periods between quinacrine insertion and hysterectomy resulted in a higher incidence of tubal closure, and she recommended an additional contraceptive for at least six weeks post-insertion. Her study also documented a positive correlation between dose of quinacrine and efficacy, but higher doses extend tubal damage beyond the intramural segment.…”

Section: Efficacymentioning

confidence: 97%

100 000 quinacrine sterilizations

Kessel

1996

Adv Contracept

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100000 quinacrine nonsurgical female sterilizations have been completed over the past decade involving transcervical insertion of quinacrine (252 mg) as pellets by one, two or three monthly insertions. No deaths have been reported and serious complications are far fewer than for surgical sterilization. Side-effects are mild and transient. Efficacy has improved from 3 pregnancy failures per 100 women at one year to approximately 1 by improved insertion technique and use of adjuvants. Long-term follow-up of early cases in Chile shows no increased risk of cancer for this method. The main advantage of quinacrine sterilization is its ability to raise contraceptive prevalence and thereby reduce maternal mortality and morbidity, especially in rural and urban slum areas of developing countries. It should be made available as an option to well informed women everywhere as an economical and safe permanent family planning method.

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Section: Efficacymentioning

confidence: 97%

100 000 quinacrine sterilizations

Kessel

1996

Adv Contracept

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“…Merchant and colleagues [18] recently found in a prehysterectomy study that greater height of the endometrium may play a protective role against the action of quinacrine.…”

Section: The Qinscrine Pellet Methodsmentioning

confidence: 97%

Studies of quinacrine and of tetracycline for non-surgical female sterilization

1987

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The transcervical quinacrine pellet method developed by Zipper and co-workers is potentially a much needed safe, inexpensive, and effective non-surgical method of female sterilization. This method utilizes an intrauterine device inserter to deposit 250 mg of quinacrine hydrochloride as pellets in the uterine cavity. No complications or side effects, other than temporary pain and oligomenorrhea, have been reported. Tetracycline has an established track record for safety. It also has been reported to have properties similar to quinacrine as a sclerosing agent, with potential as a non-surgical method using the quinacrine insertion technique. To expand the experience with quinacrine and to study tetracycline as an alternative, studies were undertaken under the auspices of the Indian Rural Medical Association in Calcutta, India. During the period 14 August, 1979 to 28 June, 1984, 414 women received three insertions of 200 mg of quinacrine. There were 29 failures and a three-year life table failure rate of 8.5. During the period 25 April, 1984 to 28 December 1984, 55 women received three insertions of 200 mg of tetracycline. By 1 June, 1986 there were 32 failures among the 55 cases for a failure rate of 58%. A more recent study using a single dose of 1000 mg of tetracycline also produced unacceptably high failure rates.

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“…They also indicated that neither the number of insertions nor the place of deposition of the pellets (whether at the fundus or at the cornual areas) affected the degree of tubal inflammation and fibrosis [9].…”

Section: Introductionmentioning

confidence: 99%

“…Zipper and associates have observed that quinacrine has an occlusive effect on the intramural portion of the human fallopian tubes [1]. In spite of the extensive clinical studies [2][3][4][5][6] and others], histopathological research on the changes that occur when quinacrine is placed into the uterus is scarce [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Histopathologic changes in the cornual portion of the fallopian tube following a single transcervical insertion of quinacrine hydrochloride pellets

Elkady¹,

Mansy

Nagib³

et al. 1991

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To study the sequence of histopathologic changes taking place in the cornual portion of the fallopian tube subsequent to exposure to quinacrine, 252 mg were inserted transcervically in 12 women awaiting hysterectomy for non-malignant conditions of the uterus. All patients who underwent surgery within ten days of insertion were found to have necrosis of the epithelial lining and an acute inflammatory reaction. Later on, the changes observed included progressive absorption of the inflammatory cellular exudate, progressive fibrosis, with partial or almost complete occlusion of the lumen, and failure of regeneration of the epithelial lining. Our results support other studies indicating that quinacrine can effectively produce tubal fibrosis and occlusion.

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Clinico-pathological study of Fallopian tubes after transcervical insertion of quinacrine hydrochloride pellets

Cited by 16 publications

References 6 publications

100 000 quinacrine sterilizations

100 000 quinacrine sterilizations

Studies of quinacrine and of tetracycline for non-surgical female sterilization

Histopathologic changes in the cornual portion of the fallopian tube following a single transcervical insertion of quinacrine hydrochloride pellets

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