Clinico-Radiological Findings of Neuro-Behcet's Syndrome.

Abstract

Weexamined 21 cases of Neuro-Beh^et's syndrome in detail, and present here their clinicoradiological characteristics. Clinically, signs of pyramidal tract and meningeal irritation were frequently observed. In contrast to previous reports, our study demonstrated a near equal frequency in the occurrence of focal cerebral lesions and that of focal brain stem lesions. Notably, our results showedthat the atrophy of both the cerebrum and the brain stem was often observed, indicating the presence of continuous disease activity in the central nervous system (CNS). In accordance with the high frequency of meningeal irritation signs, all of our cases exhibited pleocytosis in the cerebrospinal fluid (CSF). These results indicated the possibility that chemical mediators secreted from infiltrating cells in the CSF may somehow inflict damage to the CNSin

Neuro-Behçet: Pons Involvement with Longitudinal Extension to Midbrain and Hypertrophic Olivary Degeneration

“…Multiple sclerosis, for example, has a tendency for the posterior brainstem. This anterior predilection would explain why BD patients often present with a pyramidal syndrome [ 8 , 9 ].…”

Spinal cord Neurobehçet’s disease detected on magnetic resonance imaging

“…Neurobehçet’s disease is present in 10–49% 1 of patients with Behçet’s disease, and may be the presenting symptom in 5% of cases. 2 Any part of the nervous system may be involved and therefore the clinical presentation is very variable.…”

Intracranial Hemorrhage in Neuro-Behcet's Syndrome.

“…It is possible that the vascular pathologies caused by Behget's syndromeand by cyclosporine conspire to induce CNShemorrhaging in these patients. Approximately 5%of Behget'ssyndromepatients do not developmucocutaneous manifestationsevenafter neurologic involvement (16). Thus, it is important to consider neuro-Behcet's syndromeas a diagnosis in patients with intracerebral hemorrhages in general, and in patients with an acute pontine hemorrhage in particular.…”