Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study

Kim, Jae Ri; Jang, Kee Taek; Jang, Jin Young; Lee, Kyungbun; Kim, Haeryoung; Kim, Sun Whe; Kwon, Wooil; Choi, Dong Wook; Heo, Jin Seok; Han, In Woong; Hwang, Shin; Kim, Wan Joon; Hong, Seung Mo; Kim, Joo Young; Nah, Yang Won; Park, Hyoung Woo; Choi, Hye Jeong; Han, Ho Seong; Yoon, Yoo Seok; Park, Sang Jae; Hong, Eun Kyung; Seo, Hyung Il; Park, Do Youn; Kang, Koo Jeong; Kang, Yu Na; Yu, Hee Chul; Moon, Woo Sung; Lim, Chae‐Seok; Bae, Jeong Mo; Jo, Seong Mu; Lee, Wonae; Roh, Young Hun; Jeong, Jin Sook; Jeong, Chi Young; Lee, Jong Sil; Song, In Sang; Kim, Kyung Hee; Kim, Ho Gak; Cho, Chang Ho; Joo, Sun Hyung; Won, Kyu Yeoun; Kim, Hee Jin; Choi, Joon Hyuk; Chu, Chong Woo; Lee, Jun Young; Park, Il Young; Lee, Hee-Jeong; Lee, Seung Eun; Kim, Hee Sung; Lee, Hyeon Kook; Cho, Min Sun; Kim, Hongbeom; Han, Kang Min

doi:10.1016/j.hpb.2019.11.007

Cited by 35 publications

(25 citation statements)

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“…The results indicated that recurrence occurred in 13-29% of cases after curative resection, and this proportion increased to 47-62% if the patient had invasive disease [17][18][19]. While the classification of IPNB remains complex, meta-analyses and multi-center cohort studies are gradually clarifying the outcomes and prognoses [2,5,6,20,21], and there is also increasing information regarding the surveillance protocols for IPNB and appropriate postoperative follow-up [5,6,22]. The present case involved an initial pathological diagnosis of invasive carcinoma with a MUC1-expressing pancreatobiliary type, which is a known prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

Lung metastases from intraductal papillary neoplasm of the bile duct: a case report

et al. 2020

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Background Intraductal papillary neoplasm of the bile duct (IPNB) is considered a pre-cancerous biliary lesion and/or an early cancer lesion, although its classification remains unclear. The 2019 revised edition of the World Health Organization Classification of Tumors of the Digestive System proposed type 1 and type 2 as new classification categories, and meta-analyses and/or multi-center cohort studies are beginning to be reported. However, treatment for IPNB recurrence and metastasis remains unclear. Case presentation A 60-year-old man who was referred to our hospital after a suspected liver tumor was diagnosed using abdominal ultrasonography. Imaging findings revealed an irregularly shaped tumor in segment 5 (S5) of the liver (size 20 mm). The S5 lesion was suspected as IPNB, and segmentectomy was performed. The pathological findings revealed invasive carcinoma derived from IPNB, and immunohistochemistry revealed positive expression of MUC1, MUC5AC, and MUC6, but negative expression of CDX2 and MUC2. At 9 months after the surgery, computed tomography revealed a tumor in the right bile duct, which was diagnosed as liver recurrence of IPNB, and right hepatectomy was performed. The histopathological findings were the same as for the first resected specimen (i.e., IPNB). At 45 months after the second surgery, computed tomography revealed nodules in both lungs, which were diagnosed as lung metastases from IPNB and resected in two separate procedures. The pathological findings were metastatic carcinoma from IPNB for both lung lesions. The patient is currently alive and undergoing adjuvant chemotherapy (S-1), which was initiated 64 months after the first resection and 12 months after resection of the lung metastases. Conclusion We encountered a rare case of lung metastases from IPNB, which were diagnosed immunohistologically. Because IPNB is generally a slow-growing tumor, resection may be feasible for IPNB recurrence and/or metastasis, which may be detected during long-term follow-up. Thus, even if resection is performed for primary IPNB, additional surgical treatment may be feasible in this setting.

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Section: Discussionmentioning

confidence: 99%

Lung metastases from intraductal papillary neoplasm of the bile duct: a case report

et al. 2020

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“…Although the rate of absorption varies by route of exposure, cumulative evidence on the systemic distribution of silver (irrespective of route of exposure to AgNPs) has shown the liver, spleen, and kidneys to be the primary organs in which silver accumulates [Takenaka et al 2001;Kim et al 2008;Sung et al 2009;Song et al 2013;Loeschner et al 2011;Korani et al 2011Korani et al , 2013Lankveld et al 2010;Park et al 2011a;Dziendzikowska et al 2012;Lee et al 2013a,d;Smulders et al 2014;Huo et al 2015;Bergin et al 2016;Boudreau et al 2016;Chen et al 2016;Hendrickson et al 2016;Recordati et al 2016;Qin et al 2016;Tiwari et al 2017;Dasgupta et al 2019]. Silver has also been shown to distribute to the brain and ovaries/testes following pulmonary and nonpulmonary routes of exposure (Figure 5.1) [Ji et al 2007b;Kim et al 2008;Kim et al 2009b;Tang et al 2008Tang et al , 2009Takenaka et al 2001;Sung et al 2008;Lankveld et al 2010;Kim et al 2010b;Park et al 2010b;Park et al 2011a;van der Zande et al 2012;Xue et al 2012;Genter et al 2012;Lee et al 2013a,d;Braakhuis et al 2014;…”

Section: Toxicokinetic Findingsmentioning

confidence: 99%

“…Effects observed in the liver, either as histopathological changes in tissue or changes in blood chemistry indicative of liver injury/disease, have also been extensively reported in relation to oral and parenteral routes of exposure [Kim et al 2009b;Kim et al 2010b;Tiwari et al 2011;Lee et al 2013b;Kim et al 2008;Park et al 2010a;Kim et al 2010a;Yun et al 2015;Elle et al 2013;Katsnelson et al 2013;Recordati et al 2016;Qin et al 2016;Wang et al 2013;Dasgupta et al 2019]. Kidney is also a likely target organ following exposure via oral and parenteral routes, with evidence of tissue and blood chemistry changes [Kim et al 2010b;Park et al 2010a;Yun et al 2015;Qin et al 2016]. Both oral and parenteral exposure also result in changes to blood hemocytology, including red blood cells, white blood cells, platelets, and hemoglobin [Tiwari et al 2011;Katsnelson et al 2013;Qin et al 2016], which may suggest other potential target organs such as the spleen.…”

Section: Dermal Oral and Parenteral Exposurementioning

confidence: 99%

“…Oral exposure has resulted in increased MDA and NO in serum [Elle et al 2013;Shrivastava et al 2016] and superoxide anion in heart and liver [Elle et al 2013], increased metallothionein in liver and kidney [Shrivastava et al 2016], and increased markers of oxidative stress and DNA damage in urine [Hadrup et al 2012b;Shrivastava et al 2016]. Following parenteral exposure, increased levels of ROS have been measured in blood, lung, liver, and kidney, along with apoptosis in lung, liver, and kidney [Tiwari et al 2011;Kim et al 2010b], and an increase in apoptosis and oxidative stressrelated gene expression was detected in the brain [Rohman et al 2009].…”

Section: Potential Mechanisms Of Toxicitymentioning

confidence: 99%

“…Second, the PBPK model was calibrated and validated against rat data from shorter durations of exposure (1-or 28-day inhalation) at exposure concentrations of 133 µg/m 3 (1 d) or 0, 0.5, 3.5, or 61 µg/m 3 (28 days) in Takenaka et al [2001] and Ji et al [2007b]. By comparison, rats were exposed to generally higher concentrations (0,49,117, or 133 µg/m 3 and 381 or 515 µg/m 3 ) over longer durations (12 or 13 weeks) in Song et al [2013] and Sung et al [2009]. The higher tissue burdens in the shorter-term inhalation studies [Takenaka et al 2001;Ji et al 2007b] used in the PBPK modeling, extrapolated to longer-term exposures, may have contributed to over-estimation of the tissue burdens in the subchronic inhalation studies, in which there was apparently a higher clearance rate of silver from the rat lungs and liver [Sung et al 2009;Song et al 2013].…”

Section: A42 Comparison Of Model-predicted and Measured Lung And Liver Tissue Burdens In Ratsmentioning

confidence: 99%

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Current intelligence bulletin 70: health effects of occupational exposure to silver nanomaterials.

Kuempel¹,

Roberts²,

Roth³

et al. 2021

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Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular features

Stendahl

Gilani

Baştürk

et al. 2022

Cancer Cytopathology

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Background Intraductal papillary neoplasm of the bile duct (IPNB) is a rare premalignant neoplasm that can progress to invasive adenocarcinoma. In this retrospective study, cases of IPNB were reviewed to examine cytomorphologic and molecular features. Methods IPNB cytology cases with histopathologic confirmation were retrieved from the pathology archives. The cytomorphologic features such as cellularity, architecture, cell type, and cellular details were analyzed. Results The cohort included 13 cases (six brushings, six fine‐needle aspirations [FNA], and one combined brushing and FNA). The lesions involved common bile duct in nine cases (69%) and hepatic duct in four cases (31%). Original cytological diagnoses included adenocarcinoma (five, 38%), suspicious for adenocarcinoma (one, 8%), neoplasm (three, 23%), atypical (three, 23%), and reactive (one, 8%). The cytomorphologic features included moderate/high cellularity (12, 92%), papillary and/or complex papillary architecture (10, 77%), columnar cells (11, 85%), vacuolated cytoplasm (12, 92%), enlarged nuclei (13, 100%), and fine granular chromatin (12, 92%). Background mucin, necrosis and acute inflammation were seen in four (31%), four (31%), and two (15%) cases, respectively. KRAS testing was performed in nine cases with mutant KRAS found in five (56%). Conclusions Our study demonstrated that IPNB cytology specimens were relatively cellular with a wide spectrum of cytomorphology; however, most cases harbored adenocarcinoma or high‐grade dysplasia. The characteristic cytomorphologic features included papillary/complex papillary clusters of columnar cells with vacuolated cytoplasm, enlarged nuclei, and fine granular chromatin in relatively cellular specimens. KRAS mutations identified may have potential diagnostic and therapeutic implications.

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Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study

Cited by 35 publications

References 28 publications

Lung metastases from intraductal papillary neoplasm of the bile duct: a case report

Lung metastases from intraductal papillary neoplasm of the bile duct: a case report

Current intelligence bulletin 70: health effects of occupational exposure to silver nanomaterials.

Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular features

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