Clinicopathologic analysis of rhabdoid meningioma

Wu, You-Ting; Lin, Jui-Wei; Wang, Hung-Cheng; Lee, Tao-Chen; Ho, Ji-Chen; Lin, Yujun

doi:10.1016/j.jocn.2009.12.014

Cited by 15 publications

(20 citation statements)

References 19 publications

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“…The ratio of male‐to‐female incidence is 40:35, and the age distribution ranges from 2 to 84 years in previous reports with detailed data. To date 110 cases of RM in 40 articles have been reported . The most common locations were convexity (25 of 74), anterior or middle cranial fossa (10 of 74), posterior cranial fossa (13 of 74) and falx or parasagittal sinus (16 of 74).…”

Section: Discussionmentioning

confidence: 99%

“…The vast majority of meningiomas are benign, WHO grade I lesions. Rhabdoid meningioma (RM) is an uncommon tumor predominantly containing rhabdoid cells, which have a specific microscopic appearance with large, eccentric nuclei with distinct nucleoli and abundant cytoplasms containing inclusion‐like eosinophilic cytoplasms . Such rhabdoid cells are also observed in many kinds of malignant tumors, particularly kidneys and the atypical teratoid/rhabdoid tumors (AT/RTs) of the brain.…”

Section: Introductionmentioning

confidence: 99%

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Aggressive rhabdoid meningioma with osseous, papillary and chordoma‐like appearance

Karabağlı

Yavaş

2014

Neuropathology

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Meningiomas are the most common primary intracranial tumors. They are usually benign and slowly growing; however, they may show histologically malignant features categorizing them into grade II or III of World Health Organization (WHO) classification. Rhabdoid meningioma (RM) is an uncommon meningioma variant categorized as WHO grade III. The clinical course of RM is determined by local recurrences, invasion of adjacent brain and/or dura, widespread leptomeningeal dissemination, remote metastases and fatal clinical outcome. Herein we report a case with recurrent aggressive left occipital parasagittal region RM in which the patient initially declined radiation treatment. The tumor was resected four times in 5 years. Histopathological examination revealed a rhabdoid meningioma with metaplastic, papillary and chordoid differentiation. Six months after her fourth operation the patient died of progressive disease. RM is a rare subtype of malignant meningioma and the role of different adjuvant therapeutic options are still unknown. Clinical presentation, radiological features and pathologic findings of this uncommon tumor are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aggressive rhabdoid meningioma with osseous, papillary and chordoma‐like appearance

Karabağlı

Yavaş

2014

Neuropathology

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“…However, most of the cases behave aggressively. [414–17] Benign RM is the presence of rhabdoid features, either diffuse or focal, lacking the histological features of malignancy. [418] This lack of malignant features significantly inhibits the clinically aggressive behavior of RMs.…”

Section: Discussionmentioning

confidence: 99%

“…The most aggressive RMs are those mixed with papillary morphology. [131517182325–29] The question is how to manage cases of RMs without malignant features. Perry et al .…”

Section: Discussionmentioning

confidence: 99%

“…In this study, all tumors had conventional meningioma features mixed with the rhabdoid areas. [17] The authors of this study very recently republished a new series of another six cases of rhabdoid papillary meningioma with the rhabdoid features appearing also in the first presentation. [16] In our analysis of the available RM cases, we found that 79% of RM diagnosis was made in the first specimen.…”

Section: Discussionmentioning

confidence: 99%

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Primary calcified rhabdoid meningioma of the cranio-cervical junction: A case report and review of literature

Abolfotoh

Tavanaiepour

Hong

et al. 2012

J Craniovert Jun Spine

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Rhabdoid meningioma (RM) is a relatively new, rare, and aggressive subtype of meningioma, classified as Grade III malignancy in 2000, 2007 versions of WHO classification of the central nervous system. We reviewed the data available from all published cases of RMs. To the best of our knowledge, there are more than 100 published cases of RMs; none have documented extensive calcification or origin from the cranio cervical junction. We report the first case of a totally calcified (stony mass), primary RM, at the cranio cervical junction. Also, we highlighted the role of the transcondylar approach to achieve microscopic total removal of such a challenging lesion. A 37 year old female, allergic to erythromycin, presented with 5 years of progressive right upper extremity numbness and weakness, right facial numbness, and occipital pain. Imaging demonstrated a large calcified mass at the right posterior–lateral margin of the cranio cervical junction, encasing the right vertebral artery and right PICA loop. Patient underwent microscopic total resection of the lesion. Pathological diagnosis was confirmed as RM with atypical features. Subsequently, the patient received postoperative intensity modulated radiotherapy (IMRT) on the tumor bed, and close follow up imaging showed no recurrence 2 years after surgery. We report the first case of a primary RM originating from the cranial cervical junction; also, it is the first case to present with extensive calcification in this morphological subtype. We also conclude that RM has now become a feature of newly diagnosed cases and not only a disease of recurrent cases as it was thought in the past. Since RMs are typically considered aggressive, total surgical resection with close follow up and postoperative adjuvant radiation should be considered. However, the adjuvant therapy of each separate case of RM should be tailored according to its particular histopathologic profile.

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Hemorrhagic onset of rhabdoid meningioma after initiating treatment for infertility

et al. 2012

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Rhabdoid meningioma (RM) is a rare aggressive phenotype and is classified as a grade III neoplasm by the World Health Organization. A 29-year-old woman initiated treatment with clomiphene citrate for infertility. Two weeks later, she presented with acute headache and nausea. Brain computed tomography and magnetic resonance imaging demonstrated a tumor with hematoma in the left frontoparietal region. Surgical resection was performed, and the tumor was subtotally removed. The tumor was diagnosed as a rhabdoid meningioma (RM). Despite radiation and chemotherapy, she experienced regrowth and dissemination to the spinal cord. She died 11 months after onset of symptoms. Spontaneous hemorrhage is an unusual presentation of RM. In our case, infertility treatment may have triggered progression and bleeding because of an imbalance of sex hormones.

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Clinicopathologic analysis of rhabdoid meningioma

Cited by 15 publications

References 19 publications

Aggressive rhabdoid meningioma with osseous, papillary and chordoma‐like appearance

Aggressive rhabdoid meningioma with osseous, papillary and chordoma‐like appearance

Primary calcified rhabdoid meningioma of the cranio-cervical junction: A case report and review of literature

Hemorrhagic onset of rhabdoid meningioma after initiating treatment for infertility

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