Clinicopathologic Analysis With Immunohistochemistry for DNA Mismatch Repair Protein Expression in Synchronous Primary Endometrial and Ovarian Cancers

Kobayashi, Yusuke; Nakamura, Kenzo; Nomura, Hiroyuki; Banno, Kouji; Irie, Haruko; Adachi, Manabu; Iida, Miho; Umene, Kiyoko; Nogami, Yuya; Masuda, Kenta; Kisu, Iori; Ueki, Arisa; Yamagami, Wataru; Kataoka, Fumio; Hirasawa, Akira; Tominaga, Eiichiro; Susumu, Nobuyuki; Aoki, Daisuke

doi:10.1097/igc.0000000000000377

Cited by 38 publications

(29 citation statements)

References 30 publications

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“…28 Previous studies are equivocal on the interest to search for LS in case of synchronous endometrial and ovarian tumors. 35 However, these synchronous tumors seem to be more common among LSrelated EC cases.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic Characteristics of Endometrial Cancer in Lynch Syndrome

Rossi

Frère‐Belda²,

Laurent‐Puig

et al. 2017

International Journal of Gynecological Cancer

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Section: Discussionmentioning

confidence: 99%

Clinicopathologic Characteristics of Endometrial Cancer in Lynch Syndrome

Rossi

Frère‐Belda²,

Laurent‐Puig

et al. 2017

International Journal of Gynecological Cancer

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“…14 Besides, it has been suggested that most SCEOs are not hereditary cancers caused by germ line mutations, but instead, they are sporadic cancers. 13 So, we still use only histopathologic criteria to differentiate between these 2 entities.…”

Section: Discussionmentioning

confidence: 99%

Synchronous Primary Cancers of the Endometrium and Ovary With the Same Histopathologic Type Versus Endometrial Cancer With Ovarian Metastasis

Beşe

Sal²,

Kahramanoğlu

et al. 2016

International Journal of Gynecological Cancer

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The differentiation between SCEO and ECOM is of great clinical importance while our results showed a better prognosis for patients with SCEO compared with patients with ECOM. More aggressive therapeutic approaches may be considered for patients with SCEO who are older, postmenopausal, and/or have advanced grade of endometrial tumor, omental metastasis, and residual tumor. Lymphadenectomy should be performed in every patient with SCEO.

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“…In the future some molecular profiles and genetic changes that present in these tumor may improve the distinction of independent primary tumors. 9 Mean age at diagnosis of women with primary SEOC in our study was 50.9. In contrast, women who develop endometrial or ovarian cancer alone are generally postmenopausal and in the sixth or seventh decade of life.…”

Section: Discussionmentioning

confidence: 67%

Coexisting Primary Cancers of Endometrium and Ovary: Experience of Single Institution

Narin¹

2015

UHOD

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Synchronous primary cancers of the endometrium and ovary (SEOC) occur in approximately 10% of all women with ovarian cancer and 5% of all women with endometrial cancer. Diagnosis of these tumors as independent primaries or metastases is necessary for appropriate staging and treatment. We aimed to demonstrate the clinic-pathological characteristics and prognosis of patients diagnosed as SEOC. Clinico-pathological data of cases with SEOC were retrieved from the computerized database of Etlik Zubeyde Hanim Women's Health and Research Hospital. Twenty-six patients with SEOC who underwent comprehensive surgical staging between 1998 and 2014 were included in study. Mean age at diagnosis of women with primary SEOC in our study was 50.9. Median follow up was 86.5 months and the 10 year overall survival (OS) rates were 86.0% for patients with SEOC. Among the variables only omental involvement independently affected OS (p= 0.008). Most of the tumors were well-differentiated, early stage and of endometrioid cell type. In this study we showed that women with SEOC was often young and mostly have an excellent prognosis.

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Clinicopathologic Analysis With Immunohistochemistry for DNA Mismatch Repair Protein Expression in Synchronous Primary Endometrial and Ovarian Cancers

Abstract: These results suggest that most synchronous primary endometrial ovarian cancers are not hereditary cancers caused by germ line mutations but rather sporadic cancers.

Cited by 38 publications

References 30 publications

Clinicopathologic Characteristics of Endometrial Cancer in Lynch Syndrome

Clinicopathologic Characteristics of Endometrial Cancer in Lynch Syndrome

Synchronous Primary Cancers of the Endometrium and Ovary With the Same Histopathologic Type Versus Endometrial Cancer With Ovarian Metastasis

Coexisting Primary Cancers of Endometrium and Ovary: Experience of Single Institution

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