Clinicopathologic characteristics of early-onset colorectal cancer

Park, Kui Seon; Hong, Young Ki; Choi, Yoon Jung; Kang, Jung Gu

doi:10.3393/ac.2021.00976.0139

Cited by 17 publications

(8 citation statements)

References 27 publications

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“…[16,18,23,24,26,28-31] In a recent Korean study comparing EOCRCs with CRCs >50 years also showed higher poor histological differentiation in EOCRC group. [ 32 ] In this study, however, the aggressive pathologic features were not more common in EOCRC than in late-onset CRC. However, it may be explained that the number of CRC cases with aggressive pathologic features were small in this study and definition of aggressive pathologic features was different in each study.…”

Section: Discussioncontrasting

confidence: 56%

Clinical and pathological characteristics of early-onset colorectal cancer in South Korea

Park

Yoon

Kwak

et al. 2023

Saudi Journal of Gastroenterology

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Background: Early-onset colorectal cancer (EOCRC) may differ by race and ethnicity, and recently South Korea has witnessed a surge in cases. We aimed to evaluate the clinical and pathological features of patients with EOCRC, and to determine the predictors of overall survival. Methods: In this retrospective study, EOCRC was defined as CRC diagnosed in patients aged < 50 years, and late-onset CRC was defined as CRC diagnosed in those over 75 years of age. The clinical and pathological characteristics of patients with EOCRC were compared with late-onset CRC. We also used multivariable Cox proportional hazard models to find predictors of overall survival in patients with EOCRC. Results: The proportion of early-onset CRC was 9.1% of 518 patients with CRC, and the clinical and pathological characteristics were similar between early-onset (n = 47) and late-onset CRC (n = 134). However, EOCRC had a preponderance for distal tumor location (70.2% vs. 50.7%, P = 0.02) and T1-2 stage disease (23.4% vs. 11.2%, P = 0.04), compared with those of late-onset CRC. Using multivariable Cox proportional hazard models, only vascular invasion (hazard ratio = 8.75, 95% confidence interval 1.139‒67.197) was found to be a risk factor for overall survival (P = 0.04) for patients with CRC. Conclusion: EOCRC had preponderance for distal tumor location and early T-stage disease, compared with late-onset CRC. Considering the increasing incidence of EOCRC, more studies on clinical and pathological characteristics of EOCRC may be warranted.

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Section: Discussioncontrasting

confidence: 56%

Clinical and pathological characteristics of early-onset colorectal cancer in South Korea

Park

Yoon

Kwak

et al. 2023

Saudi Journal of Gastroenterology

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“…This can reflect as well different healthcare policies between nations. A study [ 20 ] reported a worse DFS in younger patients when they were stratified according to age at diagnosis: ≤40 vs. 41–64 vs. ≥65 and 21–30 vs. 31–40 vs. 41–50. The DFS did not change when they compared two groups of patients with the cut-off age of 50.…”

Section: Discussionmentioning

confidence: 99%

Different Oncologic Outcomes in Early-Onset and Late-Onset Sporadic Colorectal Cancer: A Regression Analysis on 2073 Patients

Foppa

Maroli

Lauricella

et al. 2022

Cancers

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The incidence of colorectal cancer (CRC) is increasing in the population aged ≤ 49 (early-onset CRC-EOCRC). Recent studies highlighted the biological and clinical differences between EOCRC and late-onset CRC (LOCRC-age ≥ 50), while comparative results about long-term survival are still debated. This study aimed to investigate whether age of onset may impact on oncologic outcomes in a surgical population of sporadic CRC patients. Patients operated on for sporadic CRC from January 2010 to January 2022 were allocated to the EOCRC and LOCRC groups. The primary endpoint was the recurrence/progression-free survival (R/PFS). A total of 423 EOCRC and 1650 LOCRC was included. EOCRC had a worse R/PFS (p < 0.0001) and cancer specific survival (p < 0.0001) compared with LOCRC. At Cox regression analysis, age of onset, tumoral stage, signet ring cells, extramural/lymphovascular/perineural veins invasion, and neoadjuvant therapy were independent risk factors for R/P. The analysis by tumoral stage showed an increased incidence of recurrence in stage I EOCRC (p = 0.014), and early age of onset was an independent predictor for recurrence (p = 0.035). Early age of onset was an independent predictor for worse prognosis, this effect was stronger in stage I patients suggesting a potentially—and still unknown—more aggressive tumoral phenotype in EOCRC.

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“…Korea menemukan diferensiasi karsinoma kolorektal yang buruk berhubungan signifikan pada kelompok usia ≤50 tahun (Park et al, 2022). Ghodssi et al, menemukan kelompok usia yang lebih muda (<50 tahun) juga terdiagnosis dengan diferensiasi yang lebih buruk dibandingkan dengan kelompok usia tua (≥50tahun) (14,7% vs. 8,3%; p < 0.001) (Ghodssi-Ghassemabadi et al, 2019).…”

Section: Hasil Dan Pembahasanunclassified

Diferensiasi Karsinoma Kolorektal di Rumah Sakit Umum Daerah (RSUD) Ciawi, Kabupaten Bogor Periode 2021 - 2023

Sjaiful Bachri,

Fernando Nathaniel,

Velika Elaine Kangnata

et al. 2023

JRIK

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Colorectal carcinoma, a malignant neoplasm originating from the epithelial cells of the large intestine or rectum, poses a significant health problem worldwide. The estimated global incidence of colorectal cancer was 2.17 million cases in 2019. Meanwhile, in Indonesia, colorectal cancer ranks fifth among the most common cancer cases with a mortality rate of 9.5%. Demographic characteristics, including age, gender, ethnicity, and geographic location, have been extensively studied in relation to colorectal carcinoma. Understanding the patterns of differentiation and demographic characteristics associated with this disease is crucial for the diagnosis, treatment, and overall prognosis of patients. This study is a descriptive observational study that examines the demographic characteristics and differentiation of colorectal carcinoma patients. The study sample consists of a subset of the research population at Ciawi Regional General Hospital who underwent surgery from June 2021 to May 2023. A total of 21 respondents met the inclusion criteria, with a mean age of 54 years, and were predominantly female (57.1%). The results of this study indicate that poorly differentiated colorectal carcinoma generally occurs at a younger age compared to well and moderately differentiated cases. In terms of gender, females are more likely to experience colorectal carcinoma compared to males. Further research is needed to uncover the interactions between tumor biology, demographics, and clinical outcomes, with the ultimate goal of improving the prognosis and survival rates for individuals with colorectal carcinoma.

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Clinicopathologic characteristics of early-onset colorectal cancer

Cited by 17 publications

References 27 publications

Clinical and pathological characteristics of early-onset colorectal cancer in South Korea

Clinical and pathological characteristics of early-onset colorectal cancer in South Korea

Different Oncologic Outcomes in Early-Onset and Late-Onset Sporadic Colorectal Cancer: A Regression Analysis on 2073 Patients

Diferensiasi Karsinoma Kolorektal di Rumah Sakit Umum Daerah (RSUD) Ciawi, Kabupaten Bogor Periode 2021 - 2023

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