Clinicopathologic features and prognostic analysis of MSI-high colon cancer

Lin, Chun Chi; Lai, Yanhao; Lin, Tzu Chen; Chen, Wei Shone; Jiang, Jeng Kai; Yang, Shung Haur; Wang, Huann Sheng; Lan, Yuan Tzu; Liang, Wen-Yew; Hsu, Hui Mei; Lin, Jen Kou; Chang, Shih Ching

doi:10.1007/s00384-011-1341-2

Cited by 34 publications

(31 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MSI-high is an independent favorable prognostic marker for overall survival in colon cancer. Several studies support this further by confirming that MSI-high tumors were strongly correlated with longer disease free survival and overall survival than MSI stable tumors in colon cancers [29,30].…”

Section: Discussionmentioning

confidence: 67%

Impact of microsatellite instability on survival of endometrial cancer patients

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 67%

Impact of microsatellite instability on survival of endometrial cancer patients

et al. 2014

View full text Add to dashboard Cite

show abstract

“…CRC patients with MSI tumors had more stromal FAP in the tumor center, compared to the other patient groups. This was unexpected, since MSI is considered to be a positive prognostic marker [30, 31] and was so in our study group as well [7]. …”

Section: Discussionmentioning

confidence: 74%

High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis

et al. 2013

View full text Add to dashboard Cite

-An active stroma is important for cancer cell invasion and metastasis. We investigated the expression of fibroblast activation protein (FAP) in relation to patient prognosis in colorectal cancer. Colorectal cancer specimens from 449 patients were immunohistochemically stained with a FAP antibody and evaluated in the tumor center and tumor front using a semiquantitative four-level scale. FAP was expressed by fibroblasts in 85–90 % of the tumors examined. High versus no/low expression in the tumor center was associated with poor prognosis (multivariate hazard ratio, HR = 1.72; 95 % CI 1.07–2.77, p = 0.025). FAP expression in the tumor front, though more frequent than in the tumor center, was not associated with prognosis. FAP expression in the tumor center was more common in specimens with positive microsatellite instability (MSI) screening status and in patients with high CpG island methylator phenotype (CIMP) status. However, inclusion of MSI screening status and CIMP status in the multivariate analysis strengthened the risk estimates for high FAP expression in the tumor center (HR = 1.89; 95 % CI 1.13–3.14; p = 0.014), emphasizing the role of FAP as an independent prognostic factor. Stromal FAP expression is common in colorectal cancer, and we conclude that high FAP expression in the tumor center, but not the tumor front, is an independent negative prognostic factor.

show abstract

“…Despite a trend towards an increasing percentage of right colon cancers in the eastern population, the prevalence of CIMP-H, MSI-H and BRAF mutation was low compared with that of the western population (Takada et al , 2002; Chang et al , 2006; Gao et al , 2012; Lin et al , 2012). There were gradual changes of gender distribution, T category, histologic features and the prevalence of CIMP-H and MSI-H along the bowel subsites.…”

Section: Discussionmentioning

confidence: 95%

Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location

Kim

et al. 2013

Br J Cancer

103

View full text Add to dashboard Cite

Background:Colorectal cancer (CRC) is usually categorised as proximal or distal CRC. Recently, many researchers have tried to determine the molecular heterogeneity of CRCs along bowel subsites. However, the differential effects of the CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) on the clinical outcome according to tumour location are not well-known.Methods:We analysed clinicopathologic and molecular characteristics, including CIMP, MSI, KRAS and BRAF mutations, in 734 CRCs according to bowel subsites. And the prognostic value of CIMP and MSI was analysed according to tumour location.Results:We found a linear increase of female predominance, T, N category, stage, differentiation, absence of luminal necrosis, tumour -infiltrating lymphocytes, Crohn's-like lymphoid reaction, serration and mucin production from the rectum to caecum. CpG island methylator phenotype -high and MSI-high gradually increased from the rectum to caecum. CpG island methylator phenotype is a poor prognostic factor of overall survival (hazard ratio (HR): 4.13, 95% confidence interval (CI): 1.27–13.46) and disease-free survival (HR: 2.90, 95% CI: 1.04–8.08) in rectal cancers.Conclusion:Clinicopathologic and molecular profiles of CRCs gradually change along bowel subsites, and the prognostic implication of CIMP is different according to tumour location.

show abstract

Clinicopathologic features and prognostic analysis of MSI-high colon cancer

Abstract: Based on the hospital-based study, MSI-H colon cancers demonstrated distinguished clinicopathologic features from MSI-L/S colon cancers. MSI-H is an independent favorable prognostic factor for overall survival in colon cancer.

Cited by 34 publications

References 36 publications

Impact of microsatellite instability on survival of endometrial cancer patients

Impact of microsatellite instability on survival of endometrial cancer patients

High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis

Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location

Contact Info

Product

Resources

About