Clinicopathologic features of Buschke-Löwenstein tumor: a multi-institutional analysis of 38 cases

Zhang, Dongwei; González, Raúl; Feely, Michael; Umrau, Kavita; Lee, Hwajeong; Allende, Daniela S.; Karamchandani, Dipti M.; Zaleski, Michael; Ji, Lin; Westerhoff, Maria; Zhang, Xuchen; Alpert, Lindsay; Liao, Xiaoyan; Lai, Jinping; Liu, Xiuli

doi:10.1007/s00428-019-02680-z

Cited by 14 publications

(23 citation statements)

References 21 publications

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“…El TBL es una enfermedad de transmisión sexual que aparece en el 0.1% de la población sexualmente activa y ocurre principalmente entre la cuarta y sexta década de la vida [6]. Afecta más frecuentemente a hombres (ratio de 2.7:1, algunas series indican 4.4:1), pero en algunos casos se ha descrito su aparición en mujeres y niños [7,8]. Es muy agresivo localmente, con alta tasa de recurrencia (60% -70%) y potencial de malignización (30% -56%) [7].…”

Section: Discussionunclassified

“…Es muy agresivo localmente, con alta tasa de recurrencia (60% -70%) y potencial de malignización (30% -56%) [7]. Los principales factores de riesgo para su desarrollo son la infección por VPH, fumar, y los estados de inmunodepresión (Síndrome de Inmunodeficiencia Adquirida [SIDA], terapia inmunosupresora, alcoholismo, diabetes y quimioterapia) [8][9][10].…”

Section: Discussionunclassified

“…Los síntomas comúnmente presentados son el dolor, malestar, sangrado, la presencia de lesión en masa y secreción. Una serie de 38 casos reportó que el tamaño y grosor promedio de los tumores revisados se encontró entre 2 -14 cm y 0.2 -2.5 cm respectivamente, por lo que podemos considerar que el caso que exponemos es raro, al tener un tamaño mayor al promedio [8].…”

Section: Discussionunclassified

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Tumor de Buschke – Löwenstein

Leone¹,

Carvajal²

2022

Rev. Oncol. Ecu.

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Introducción: El tumor de Buschke – Lowenstein (TBL) es enfermedad de transmisión sexual causada por el virus del papiloma humano (VPH), descrita como una forma intermedia entre un condiloma acuminado y un carcinoma de células escamosas. Afecta principalmente al área genital y anorrectal, posee capacidad de transformación maligna y una alta tasa de recurrencia. La cirugía es el tratamiento de primera línea. Caso clínico: Presentamos el caso de un paciente masculino de 27 años con lesiones verrucosas de crecimiento progresivo en el área inguinal y genital. Mediante la correlación clínico-patológica se llegó al diagnóstico de TBL. Tras discusión en comité multidisciplinario se declaró irresecable y se resolvió tratamiento con radioterapia, además vacunación terapéutica contra el VPH, tanto sistémica como intralesional. Conclusión: El TBL es localmente agresivo y de difícil tratamiento, por lo que la prevención contra el VPH es fundamental. La vacunación terapéutica en conjunto con la radioterapia ofreció mejoría clínica.

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Section: Discussionunclassified

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Tumor de Buschke – Löwenstein

Leone¹,

Carvajal²

2022

Rev. Oncol. Ecu.

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“…One multi-institutional evaluation of 38 cases of B-L showed malignancy in 19 (50%) cases, associated with high-risk HPV. 6 It is unclear if these lesions developed malignancy because of high-risk HPV superinfection. Furthermore, these authors include patients with lesions that are smaller than would meet our B-L definition and hence were more likely squamous cell carcinoma at presentation.…”

Section: Malignancy Mortality and Recurrencementioning

confidence: 99%

Buschke-Lowenstein Tumors: A Review and Proposed Classification System

Davis¹,

Barton²,

Orangio³

et al. 2021

Sexual Trans Dis

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Buschke-Lowenstein (B-L) tumors or giant condylomata are large fungating lesions that are caused by human papillomavirus (HPV) and develop in the anogenital region. Although uncommon, physicians and surgeons who treat sexually transmitted diseases or other diseases involving the anogenital area will encounter these patients. The purpose of this study is to review the current literature regarding these lesions. We evaluated every published study in PubMed and Embase from 1925 to 2020, concentrating on the clinical data included in each report, such as presentation and treatment. We also evaluated each work for any definition used and found that there is no accepted definition for these lesions. As such, we provide an inclusive, workable definition. In addition, there are many misconceptions about B-L that continue to be propogated as more case reports are published every year. After evaluating every published case, we refute the fact that these lesions have a high mortality or a high malignancy rate. Furthermore, we refute that these lesions are synonymous with verrucous carcinoma. In addition to a definition, we also propose a simple grading system that we hope can be used to assist in the study and management of these patients moving forward. Although the literature is very heterogenous regarding B-L, they are caused by HPV and are distinct from verrucous carcinoma. Because of the majority of information is based on case reports, the literature concentrates on treatment, but more work is clearly needed to delineate the association with specific HPV types and optimal management of this disease.

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“…Clinically, it appears as a giant conylomata acuminata with local aggressiveness, causing destruction by contiguity and a high recurrence rate (Figure 1). 1…”

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confidence: 99%

Perianal Buschke-Löwenstein Tumor

Truyols

Mir-Bonafé

2020

J Cutan Med Surg

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Buschke-Löwenstein tumor is a rare sexually transmitted disease, characteristic of immunosuppressed patients, associated with the human papillomavirus infection, being the 6 and 11 serotypes most frequently involved. Some authors consider it a low-grade squamous cell carcinoma, whereas others consider it as a transitional form between squamous cell carcinoma and condylomata acuminata. Clinically, it appears as a giant conylomata acuminata with local aggressiveness, causing destruction by contiguity and a high recurrence rate (Figure 1). 1

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Clinicopathologic features of Buschke-Löwenstein tumor: a multi-institutional analysis of 38 cases

Cited by 14 publications

References 21 publications

Tumor de Buschke – Löwenstein

Tumor de Buschke – Löwenstein

Buschke-Lowenstein Tumors: A Review and Proposed Classification System

Perianal Buschke-Löwenstein Tumor

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