Clinicopathologic features of nasopalatine duct cysts: A retrospective study in two Brazilian oral and maxillofacial pathology referral centers

Abstract

Background Nasopalatine duct cyst (NDC) is the most common non-odontogenic cyst in the oral cavity. Clinically it is not difficult to suspect these lesions based on clinical and radiographic appearance. However, the histopathological diagnosis may be difficult due to the broad morphological diversity of these lesions. The objective was to analyze the clinicopathological features of NDCs diagnosed in two oral and maxillofacial pathology services in the Brazilian northeast. Material and Methods A retrospective clinicopathologic study was performed. A total of 18,121 clinical records of oral lesions from two oral and maxillofacial pathology services in Brazil were analyzed (2000-2020). All NDCs cases were revised and demographic, clinical, radiographic, and histopathological data were collected. Results Among 18,121 diagnoses in the oral pathology services, 45 (0.2%) were NDCs. The series comprises 24 males (53.3%) and 21 females (46.7%), with a mean age of 43.2 years-old. Most lesions were asymptomatic (n = 27, 60%) with an mean size of 2.1 cm. Microscopically, the non-keratinized stratified squamous epithelium was the most common (66.7%). However, in 88.9% of cases, the epithelial lining was varied and composed of two or more types of epithelium. There was no significant association between the type of epithelium and the size of the cysts ( p = 0.389). Nerve, blood vessels, hemorrhage, and chronic inflammatory infiltrate were commonly observed. In contrast, there was a low frequency of mucous glands, sebaceous glands, cholesterol clefts, and multinucleated giant cells. Conclusions The clinical, radiographic, and microscopic findings observed in this study are similar to those reported in the literature. Due to the morphological diversity of NDC, it is needed to correlate its histopathological features with the clinical and radiographic findings to establish a correct diagnosis. Key words: Oral cavity, oral pathology, nonodontogenic cysts, diagnosis.

Efficacy of Fenestration Decompression for the Treatment of Oral and Maxillofacial Cysts

“…Patients were assigned to two groups based on the treatment plan they received: the control group ( n = 64) treated with curettage of cysts and the observation group ( n = 71) with FD. Inclusion criteria were as follows: (1) presence of with oral and maxillofacial cysts [ 10 ], (2) in accordance with the surgical indications, (3) good oral condition and healthy periodontal tissue, (4) compliance with the doctor's orders to complete oral hygiene and cleaning, (5) and complete clinical data. Exclusion criteria were as follows:: (1) pregnant and lactating women, (2) alcoholic fatty liver disease and/or various types of viral hepatitis, (3) serious cardiocerebrovascular and blood system diseases, (4) organic mental disorders, (5) high risk of malignancy in cysts, and (6) incomplete clinical data and refusing to participate in the study.…”

“…(1) presence of with oral and maxillofacial cysts [10], (2) in accordance with the surgical indications, (3) good oral condition and healthy periodontal tissue, (4) compliance with the doctor's orders to complete oral hygiene and cleaning, (5) and complete clinical data. Exclusion criteria were as follows::…”

Nasopalatine Duct Cyst with Impacted Inverted Mesiodens: A Rare Case Report and Literature Review

“…NPDC is one of the many gnathic pathologies but is distinctive in that it is site-specific (seen in only the midline of the maxillary anterior region) [36,39]. NPDCs generally exhibit an age predilection (frequently seen in the age range of 40-60 years), although it may affect any age group [36,37,[39][40][41]. However, age should not be a criterion to rule out its occurrence in the younger age group, as a case of NPDC has been documented in a 7-year-old child [35,42].…”

“…Owing to their slow-growing asymptomatic nature (40% of cases), they are usually observed as incidental findings during regular clinical and radiographic investigations [ 13 , 17 , 37 , 38 , 40 , 43 , 44 ]. A tiny asymptomatic swelling just behind the palatine papilla is the presenting symptom in most cases; however, a few cases may present a midline swelling on the labial aspect of the alveolar ridge.…”

“…Radiographically, NPDC generally exhibits a well-circumscribed, unilocular midline radiolucency, with an oval/round shape [ 35 – 37 , 40 , 43 ]. However, a few cases may present as a heart-shaped lesion, either due to notching by the nasal septum or superimposition of the nasal spine on the radiolucent area [ 36 , 37 , 43 ].…”