Clinicopathologic importance of atypical glandular cells in cervico-vaginal cytology

Yüksel, Seda; Şimşek, Erhan; Yetkinel, Selçuk; Alemdaroğlu, Songül; Bolat, Fılız; Çelik, Hüsnü

doi:10.4274/jtgga.galenos.2019.2019.0059

Cited by 4 publications

(6 citation statements)

References 16 publications

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“…AIS lesions are precursors to invasive adenocarcithat tend to be deep and highly localized in the cervical crypt, making these lesions difficult to recognize. 27 They are also not easy to recognize by colposcopy. The advantage of the Pap test is that in cases with uncertain lesions the cells in a lesion can be extensively sampled.…”

Section: Discussionmentioning

confidence: 99%

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Utility of p16/Ki67 double immunocytochemistry for detection of cervical adenocarcinoma

Ryu

Honma

Shingetsu

et al. 2022

Cancer Cytopathology

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BACKGROUND:Although the incid ence of cervical ad enocarcinoma has consistently increased , especially among young women, there is no established best means for screening. This study evaluated the screening efficacy of CINtec PLUS (CINtec; p16/Ki67 d ouble immunocytochemistry) expression in cervical gland ular cells. METHODS: Cervical cytology was examined using abnormal gland ular cells. The CINtec status of 100 samples with correspond ing surgically resected specimens and 11 samples that exhibited negative results for intraepithelial lesion or malignancy at follow-up was analyzed . Ad d itionally, 31 negative samples containing benign glandular cells were included. RESULTS: Of the 142 samples, CINtec status was diffusely positive in 74, focally positive in 24, and negative in 44. The 74 d iffusely positive samples includ ed 70 ad enocarcinomas (62 cervical, seven uterine, and one ovarian) and four cases of high-grad e cervical intraepithelial neoplasia. The 24 focally positive samples included 15 adenocarcinomas (seven cervical, seven uterine, and one fallopian tube) and nine without malignancy. The 44 negative samples included nine adenocarcinomas (five uterine and four cervical) and 35 without malignancy.The sensitivity, specificity, positive predictive value, and negative predictive value of the CINtec diffusely or focally positive cases for cervical adenocarcinomas were 94.5%, 58.0%, 70.4%, and 90.9%, respectively. In CINtec diffusely positive cases, the respective values were 84.

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Section: Discussionmentioning

confidence: 99%

“…AIS lesions are precursors to invasive adenocarcinoma that tend to be deep and highly localized in the cervical crypt, making these lesions difficult to recognize 27 . They are also not easy to recognize by colposcopy.…”

Section: Discussionmentioning

confidence: 99%

Utility of p16/Ki67 double immunocytochemistry for detection of cervical adenocarcinoma

Ryu

Honma

Shingetsu

et al. 2022

Cancer Cytopathology

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“…The solvent slides were prepared by liquid-based cytology. Disease-level cytological classifications were performed according to the Bethesda 2001 criteria (TBS2001) 15 H), internal epithelial lesion of low-grade scoliosis (L-SIL), and high-grade scoliosis internal epithelial damage (H-SIL). Cells isolated for HPV DNA extraction are stored in the vehicle.…”

Section: Methodsmentioning

confidence: 99%

Genotype Distribution and Prevalence of Human Papillomavirus Infection in Women in Northern Jiangsu Province of China

Wang¹,

Chen²,

Jiang³

2021

CMAR

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Objective Human papillomavirus (HPV) infection is the risk factor for cervical cancer. Consequently, HPV DNA testing is an essential method for cervical cancer screening. Yet, data on the prevalence and genotype distribution of HPV and cervical cytological among women in northern Jiangsu Province of China are very limited. Materials and Methods A total of 36,500 women were enrolled at the Department of Pathology of Jinhu County People’s Hospital between January 1, 2016 and December 31, 2019. HPV genotypes was performed using YanengBio ® Human Papillomavirus Genotyping Kit. Thin liquid cytology tests (TCT) were conducted, based on cytology conditions set by Bethesda in 2001. Results The overall prevalence of HPV infection was 28.95%; it was age-dependent; the number of infections was highest in the 40–49 age group. Six thousand three hundred eighty-two women (16.87%) were found to have a pure high-risk HPV infection, while 918 women (2.43%) were found to have a pure low-risk HPV infection. The 6 most predominant genotypes were HPV 52, 58, 16, 53, 56, and 33. Moreover, 8923 women (45.09%) were affected by ASCUS, 4531 (22.90%) by LSIL, 3726 (18.83%) by ASC-H, and 2610 (13.19%) by HSIL. Conclusion This study revealed a high burden of HPV infection among women in northern Jiangsu Province of China and identified the distribution of the prevalent top 6 HPV genotypes in this area, which can be used as a useful reference for future work.

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“…In our study, the incidence of premalignant and malignant lesions in the endometrium and cervix was 27.6%. It was reported as 19%‐59% in patients with AGC‐NOS cytology results in previous studies 9,18‐20 …”

Section: Discussionmentioning

confidence: 88%

“…Of these, 4.3% was endometrial cancer and 2.4% was cervical cancer. Similarly, Yüksel et al 18 concluded that malignancy was 6.6% in patients with AGC‐NOS. In other studies, the frequency of endometrial cancer was reported between 2%‐4.8%, while cervical cancer frequency was 2.5%‐6% 2,23 …”

Section: Discussionmentioning

confidence: 93%

Clinicopathological features of atypical glandular cells, not otherwise specified, on cervicovaginal pap smears

et al. 2023

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Objective:The Papanicolaou (Pap) smear test is a standard screening test that detects cervical lesions and cancers. In this multicentric study, we performed a retrospective analysis of cytological results associated with atypical glandular cells, not otherwise specified (AGC-NOS). Methods: We retrospectively reviewed Pap smear tests that resulted as AGC-NOS. A total of 254 women who underwent colposcopy due to a Pap smear result of AGC-NOS were included the study between 2003 and 2021. The ages, Pap smear results, HPV results if any, colposcopic biopsy results, endocervical and endometrial pathology results, and management of these patients were analysed. Results: Two hundred fifty-four patients with AGC-NOS Pap smear results were included in the study. A total of 70 (27.6%) patients had cervical and endometrial premalignant or malignant lesions. Malignancy was observed in 17 (6.7%) patients (endometrium, n = 11 [4.3%]; cervix, n = 6 [2.4%]). Isolated premalignant or malignant lesions of the cervix and endometrium were detected in 57 (22.4%) and 12 (4.7%) patients, respectively. Conclusions: Patients diagnosed with AGC-NOS should undergo a careful evaluation with all clinicopathological features. Because cancer of the cervix and endometrium is not rare in patients diagnosed with AGC-NOS, colposcopic examination with endocervical sampling should be a priority based on a cervicovaginal smear. Endometrial sampling is also required according to the patient's clinic, age, and examination characteristics.

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Clinicopathologic importance of atypical glandular cells in cervico-vaginal cytology

Cited by 4 publications

References 16 publications

Utility of p16/Ki67 double immunocytochemistry for detection of cervical adenocarcinoma

Utility of p16/Ki67 double immunocytochemistry for detection of cervical adenocarcinoma

Genotype Distribution and Prevalence of Human Papillomavirus Infection in Women in Northern Jiangsu Province of China

Clinicopathological features of atypical glandular cells, not otherwise specified, on cervicovaginal pap smears

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