Clinicopathologic profile of squamous cell carcinomas in resected specimens of upper aerodigestive tract: A retrospective study of 72 cases

Abstract

Background: Malignancies of head and neck, especially oral cancers are aggressive epithelial cancers and its incidence is specially high in developing countries like India. Few of the common risk factors associated with these tumours are cigarette smoking, alcohol intake and tobacco chewing. These tumours pose a serious public health issue since majority of these patients present at advanced stage of the disease. This study was aimed to evaluate the clinicopathologic characteristics and demographic data associated with squamous cell carcinomas (SCC) of head and neck. Material and Methods: This is a retrospective study conducted in 72 resected specimens of malignancies of Head and Neck over a three year study period. Results: A female predominance was noted (M:F = 0.5:1) with majority in age group between 40-50years. Commonest site was in oral cavity, especially in buccal mucosa and this was seen more often in females. Cigarette smoking was more commonly seen in males when compared to females and the difference was statistically significant (p<0.00001), while tobacco chewing was commonly seen in females than males, the difference was statistically insignificant. There were almost equal number of well and moderately differentiated tumours with 40% of total cases showing lymph node metastasis at time of presentation. Conclusion:The occurrence of most of these tumours in oral cavity buccal mucosa and in females could be linked to the tobacco chewing practice in this population. A proper and strict community education and awareness could possibly lead to decrease its incidence.

Application Value of the Diagnosis during Early Carcinoma of Upper Digestive Tract Based on Optical Enhanced Endoscopic Technique

“…Optical enhanced endoscopy has high diagnostic efficiency in real-time diagnosis and differentiation of pathological types of colorectal micropolyps and can reach the broad value of “discovery -retention” and “resection-discard” strategies of electronic staining endoscopy developed by ASGE for micropolyps [ 26 ]. The optical enhanced endoscopic technique uses the white light filter and filter calculation of the light source to obtain the narrow band spectrum, through the careful observation of the patient's lesion fine structure and imaging [ 27 , 28 ]. In addition, electronic endoscopic staining, amplification technology, and mucosal staining can be used to further determine the depth of infiltration of early esophageal cancer.…”