Clinicopathologic significance of CD105-assessed microvessel density in glottic laryngeal squamous cell carcinoma

Zvrko, Elvir; Mikić, Aleksandar; Vučković, Ljiljana

doi:10.1016/j.anl.2009.05.005

Cited by 9 publications

(12 citation statements)

References 36 publications

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“…Bodnar et al reported higher MVD values in a group of patients with laryngeal cancers [23]. Zvrko et al reported results similar to our findings among patients with glottis and epiglottis cancers [24, 25]. However, Martone et al, Shimming et al, and Chien et al reported lower MVD values [14, 17, 26].…”

Section: Discussionsupporting

confidence: 86%

Microvessel density in head and neck squamous cell carcinoma

Szafarowski

Sierdziński

Szczepański

et al. 2018

Eur Arch Otorhinolaryngol

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PurposeMicrovessel density (MVD) corresponds to the intensity of neo-angiogenesis. MVD assessments are based on the expression levels of the vascular endothelium markers such as, e.g., CD34 or CD105. The goal of this study was to assess MVD among patients with head and neck squamous cell carcinoma (HNSCC), and to evaluate the predictive value of MVD in head and neck cancers.MethodsThe study included 49 patients treated for HNSCC and 11 patients with dysplasia of the upper respiratory tract epithelium. Control tissues consisted of 12 normal mucous membranes of the throat. Expression levels of MVD markers were assessed by immunohistochemistry (IHC) using tissue microarrays (TMA). Clinicopathological factors and patients’ survival over the 5-year follow-up period were analyzed.ResultsThe MVD/CD34 values were found to be significantly elevated in the HNSCCs compared to the non-malignant control tissues (p = 0.001) and to dysplastic tissues. (p = 0.02). Significantly higher MVD/CD105 values were also seen in the tumor compared to the control tissues (p = 0.001) or the dysplastic tissues (p = 0.001). Unexpectedly, significantly lower MVD/CD34 values were seen in the tumor tissues of patients with the T3–T4 tumors compared to those with T1–T2 tumors (p = 0.01).ConclusionsHNSCCs have statistically higher MVD values compared to dysplasia of the upper respiratory tract epithelium. However, the MVD/CD34 values did not correlate with local invasiveness (the T feature) of HNSCCs. This counterintuitive observation suggests that assessments of MVD as performed on TMA by IHC using anti-CD34 or anti-CD105 antibodies considered to be specific for endothelial cell markers might underestimate the extent of the tumor vascularity in HNSCC.

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Section: Discussionsupporting

confidence: 86%

Microvessel density in head and neck squamous cell carcinoma

Szafarowski

Sierdziński

Szczepański

et al. 2018

Eur Arch Otorhinolaryngol

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“…Since SCCs arising from different regions of the larynx differ in their typical clinical behaviour, the research group at the Montenegro Clinical Centre in Podgorica recently investigated CD105 expression specifically in supraglottic (47) and glottic (48) SCCs. In the supraglottic series (47), CD105‐assessed MVD was determined in 40 samples drawn from completely resected tumours: statistical analysis showed a significant correlation between a high CD105‐assessed MVD and pN+ category, advanced stage (III and IV) and loco‐regional recurrence; a high CD105‐assessed MVD was the only independent marker of recurrent disease.…”

Section: Resultsmentioning

confidence: 99%

CD105 is a marker of tumour vasculature and a potential target for the treatment of head and neck squamous cell carcinoma

Marioni

D’Alessandro

Giacomelli

et al. 2010

J Oral Pathology Medicine

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Prospective studies are mandatory to confirm that CD105 expression is a significant prognostic hallmark in HNSCC. The results of prospective studies could be relevant for the adoption of stricter follow-up protocols and/or alternative therapeutic regimens for patients with a high CD105 expression in HNSCC. Great interest is currently being focused on vascular targeting for therapeutic purposes. Preclinical studies on appropriate animal models resembling HNSCC to investigate the effects of inhibiting CD105 may show the efficacy of combined treatment strategies associating angiogenic-targeted with conventional therapies for HNSCC.

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“…it was hypoxia-inducible factor-1α (hiF-1α), suggesting that MTa1 may be a possible angiogenesis-promoting molecule in malignant tumors (16,17).…”

Section: Discussionmentioning

confidence: 99%

“…its gene is located on chromosome 9q34 (17). recent investigations have found that in different tumors, MTa1 protein significantly correlates with tumor angiogenesis, suggesting MTa1 may be a possible angiogenesis-promoting molecule in malignant tumors (4,14,15,16,17). accordingly, the present study aimed to determine the role of MTa1 protein in the biologic behavior of oral SCC and its relation with tumor angiogenesis.…”

Section: Introductionmentioning

confidence: 88%

See 1 more Smart Citation

Metastasis-associated protein 1 expression in oral squamous cell carcinomas: correlation with metastasis and angiogenesis

Andisheh-Tadbir¹,

Najvani²,

Pardis³

et al. 2014

TJPATH

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Objective: Metastasis-associated protein 1 (MTa1) has been associated with poor prognosis in several carcinomas. recent investigation has found that in different tumors, MTa1 protein significantly correlates with tumor angiogenesis, suggesting that MTa1 may be a possible angiogenesis-promoting molecule in malignant tumors. Thus, the current study was performed to determine the role of MTa1 protein in the biological behavior of oral squamous cell carcinoma and its relation with tumor angiogenesis.Material and Method: in this study, 44 oral squamous cell carcinomas and 15 normal epitheliums were reviewed by ihC staining for MTa1 and CD105. Results:Frequency of MTa1 expression in SCCs was recorded as 97.7%, which was significantly higher than that of the control group (33.3%). Mean percentage of MTa1 expression in oral squamous cell carcinomas was 76.88 ± 25.33% which was significantly higher than that of the control group (22.81 ±10.83). Our data showed a correlation between MTa1 expression with lymph node metastasis, tumor size and, stage. Evaluation of the correlation between MTa1 protein expression and micro vessel density showed that high micro vessel density was detected more frequently in tumors with MTa1 protein overexpression than in those without overexpression.Conclusion: in the present study, high expression of the MTa1 protein was seen in oral squamous cell carcinoma, and was closely associated with tumor progression and increased tumor angiogenesis. The findings may indicate that MTa1 protein has clinical potentials as a useful indicator of progressive phenotype, a promising prognostic predictor to identify patients with poor prognosis and may be a potential novel therapeutic target of anti-angiogenesis for patients with oral squamous cell carcinoma.Key Words: MTa-1 protein, Squamous cell carcinoma, immunohistochemistry, Metastasis, head and neck neoplasms Bulgular: Skuamoz hücreli karsinomlarda MTa 1 ekspresyonu %97,7 iken kontrol grubunda bu oran %33,3 olup karsinomlarda belirgin olarak yüksek saptanmıştır. MTa1 ekspresyonunun oral skuamoz hücreli karsinomlarda ortalama yüzdesi 76,88±%25,33 olup, kontrol grubundan belirgin olarak yüksektir (22,81±10,83). Sonuçlarımız lenf nodu metastazı, tümör boyutu ve evre ile MTa1 ekspresyonu arasında ilişkiyi desteklemiştir. MTa1 protein ekspresyonu ve mikrodamar dansitesi ilişkisi araştırıldığında yüksek mikrodamar dansitesinin MTa1 overekspresyonu gösteren tümörlerde, overekspresyon göstermeyen tümörlere göre daha sık olduğu saptanmıştır.Sonuç: Çalışma, oral skuamöz hücreli karsinomlarda yüksek MTa1 protein ekspresyonunun görüldüğünü ve bu ekspresyonun tümör progresyonu ve artmış tümör anjiyogenezi ile yakın ilişkisini göster-miştir. Bulgular MTa1 proteinin tümörün progresiv fenotipinin saptanmasında kullanılabileceğini, kötü prognozu belirleyen prognostik bir belirteç olarak klinik potansiyeli olabileceğini göstermektedir ve ayrıca oral skuamöz hücreli karsinom hastalarında antianjiyogenezise yönelik hedef tedavilerinde kullanılabilme potansiyeline sa...

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Clinicopathologic significance of CD105-assessed microvessel density in glottic laryngeal squamous cell carcinoma

Cited by 9 publications

References 36 publications

Microvessel density in head and neck squamous cell carcinoma

Microvessel density in head and neck squamous cell carcinoma

CD105 is a marker of tumour vasculature and a potential target for the treatment of head and neck squamous cell carcinoma

Metastasis-associated protein 1 expression in oral squamous cell carcinomas: correlation with metastasis and angiogenesis

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