Clinicopathologic significance of claudin-6, occludin, and matrix metalloproteinases −2 expression in ovarian carcinoma

Wang, Liping; Jin, Xiangshu; Lin, Dongjing; Liu, Zhijing; Zhang, Xiaowei; Lü, Yan; Liu, Yuanyuan; Wang, Min; Yang, Minlan; Li, Jiuxia; Quan, Chengshi

doi:10.1186/1746-1596-8-190

Cited by 40 publications

(32 citation statements)

References 42 publications

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“…These results may suggest that the changes in these bacteria genera influence the differentiation of and functionality of the epithelial barrier (Wang et al 2013). Therefore, it is plausible that the preventive effect of cocoa and/or cocoa fibre on certain intestinal chronic/inflammatory diseases may at least in part result from effects on TLRs and occludin.…”

Section: Discussionmentioning

confidence: 97%

Prebiotic effects of cocoa fibre on rats

Massot-Cladera

Costabile

Childs

et al. 2015

Journal of Functional Foods

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The impact of cocoa on microbiota composition, its crosstalk with the immune system and the SCFA production, focusing on the involvement of cocoa fibre were investigated Wistar rats were fed for 3-weeks a standard diet, a diet containing 10%-cocoa (C10), cocoa fibre (CF) or inulin (I).Faecal and serum samples were collected before and after the intervention and caecal content and colon sample were collected at the end. Microbiota composition and IgA-coated bacteria and the SCFA content was quantified. The colonic expression of immune-related genes was studied. The CF diet increased Bifidobacterium and Lactobacillus counts, the proportion of IgA-coated bacteria, the SCFA concentrations and the TLR2, TLR5, TLR7 and occludin expression. With the exception on Lactobacillus counts, the I diet modified the other variables in a more modest way than the CF diet. The CF, unlike from the C10 diet, has prebiotic effects and modulates intestinal immune markers.

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Section: Discussionmentioning

confidence: 97%

Prebiotic effects of cocoa fibre on rats

Massot-Cladera

Costabile

Childs

et al. 2015

Journal of Functional Foods

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“…Claudin-6 is located at chromosome 16p13.3 and encodes a 219-amino-acid protein with a molecular mass of 23 kDa. 17 As an important component of TJs, claudin is not only capable of regulating intercellular material flow and maintaining epithelial cell polarity but also involved in cell proliferation, gene transcription, and tumor suppression. 18 Claudin downregulation can influence the initiation and progression of cancer by causing a decrease in cell adhesiveness and cohesion, variation in differentiation, and an increase in cell invasiveness.…”

Section: Discussionmentioning

confidence: 99%

Low claudin-6 expression correlates with poor prognosis in patients with non-small cell lung cancer

Wang¹,

Zhang²,

Zhang³

et al. 2015

OTT

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ObjectiveClaudins are found in junctional complexes mediating cell adhesion and are involved in the attachment of tight junctions to the underlying cytoskeleton. Abnormal claudin-6 expression has been observed for a variety of malignant solid tumors, but the expression of claudin-6 in non-small cell lung cancer (NSCLC) has not yet been characterized.MethodsImmunohistochemistry, reverse transcription-polymerase chain reaction (RT-PCR), and western blot analysis were used to quantify claudin-6 expression in 123 cases of NSCLC and non-cancerous adjacent tissue. We analyzed the relationship between claudin-6 expression and clinicopathological features of NSCLC. The Kaplan–Meier method was used to analyze postoperative survival rates, and the log-rank test was used to assess differences in survival rates. The Cox regression model was used to perform multivariate analysis.ResultsClaudin-6 expression was low for 61 of 123 (49.6%) NSCLC tissue samples and for 33 of 123 (26.8%) normal adjacent tissue samples. RT-PCR and western blot analyses confirmed the immunohistochemistry results. Claudin-6 expression was associated with lymph node metastasis (P<0.001) and TNM stage (P=0.007). Kaplan–Meier analysis indicated that patients with low claudin-6 expression had significantly lower survival rates than those with high claudin-6 expression. Multivariate analysis suggested that low claudin-6 expression was an independent indicator of prognosis in NSCLC patients.ConclusionLow claudin-6 expression is an independent prognostic biomarker that indicates a worse prognosis in patients with NSCLC.

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“…Usually it is diagnosed at an advanced stage and, therefore, despite improvements in treatment, the survival rate remains low at less than 45% after 5 years [1-4]. Marked geographic variation in incidence rates suggests an important role of behavioral and potentially modifiable factors such as diet in ovarian cancer development.…”

Section: Introductionmentioning

confidence: 99%

Cruciferous vegetables consumption and the risk of ovarian cancer: a meta-analysis of observational studies

Han

2014

Diagn Pathol

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BackgroundTo quantify the effect of cruciferous vegetable consumption on the incidence of ovarian cancer by meta-analyzing the existing observational studies and provides quantitative and high-level evidence.MethodsA detailed literature search of Medline and EMBASE for all relevant papers published. A meta-analysis was conducted for the association between cruciferous vegetable consumption and risk of ovarian cancer.ResultsA total of 4,306 cases in 375,562 controls in 11 independent studies were identified in this current meta-analysis. The result of this current meta-analysis, including 6 case-control and 5 cohort studies, indicated that cruciferous vegetable intake was associated with a reduced risk of ovarian cancer. Cruciferous vegetable consumption was associated with a reduced risk of ovarian cancer in case-control studies (RR=0.84; 95% CI, 0.75-0.94) but not in cohort studies (RR=1.00; 95% CI, 0.85-1.11).ConclusionsThe results from this meta-analysis of observational studies demonstrate that cruciferous vegetable consumption is a prospective factor of the ovarian cancer. However, more in-depth studies are warranted to report more detailed results, including other specific vegetables within the cruciferous vegetable family.Virtual slidesThe virtual slide (s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1116708293115581.

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Clinicopathologic significance of claudin-6, occludin, and matrix metalloproteinases −2 expression in ovarian carcinoma

Cited by 40 publications

References 42 publications

Prebiotic effects of cocoa fibre on rats

Prebiotic effects of cocoa fibre on rats

Low claudin-6 expression correlates with poor prognosis in patients with non-small cell lung cancer

Cruciferous vegetables consumption and the risk of ovarian cancer: a meta-analysis of observational studies

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