Clinicopathologic spectrum of necrotizing lymphadenitis

Nair, Indu R.; Balan, Suma; Phalak, Pooja; Daniel, Menila

doi:10.4103/ijpm.ijpm_622_19

Cited by 11 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For severe cases and also when supportive measures fail to resolve symptoms corticosteroids are been used (Dalugama and Gawarammana, 2017). Steroid therapy is recommended only when KFD is associated with hemophagocytic syndrome, SLE, or other rheumatic disorders (Famularo et al, 2003;Nair et al, 2020). In our case patient was prescribed with Piperacillin Tazobactum for 7 days and tablet Paracetamol was also given.…”

Section: Resultsmentioning

confidence: 95%

“…Histopathologic studies cannot be ruled out at any time so patients with KFD need to be evaluated for SLE and should have a long term follow up because of possible onset of SLE (Kampitak, 2008). Three main patterns are identi ied in lymph node biopsy i.e proliferative, necrotizing and xanthomatous (Ifeacho et al, 2008;Nair et al, 2020). Among these three types xanthomatous type is often rare with abundant foam cells.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A Rare Necrotizing Lymphadenitis: Kikuchi-Fujimoto Disease

Raj¹,

Ravi²,

Roshni³

et al. 2020

ijrps

View full text Add to dashboard Cite

Kikuchi-Fujimoto disease also known as necrotizing lymphadenitis is a rare, self limiting cause of lymphadenitis with unknown etiology and pathogenesis. The clinical signs and symptoms include cervical lymphadenopathy, fever, less frequent chills, night sweats, arthralgia, rash, weight loss and symptoms of respiratory infections. Diagnosis is often based on histopathological studies involving lymph node. It is often misdiagnosed with SLE, Lymphoma etc. There is no treatment guidelines given for KFD after diagnosis it is often limited to treat the symptoms but in severe cases corticosteroids can be given. Here we discuss a 14yr old female patient presented with evening rise of temperature and significant weight loss of approximately 5kg. Along with that she has also complained about bilateral axillary swelling of small size with pain. The final diagnosis was based on lymph node biopsy indicating Kikuchi-Fujimoto disease also the laboratory values were also elevated. After diagnosis patient was treated with symptomatically and the condition of the patient also improved. Although Kikuchi-Fujimoto disease can be misdiagnosed with other diseases, a systematic diagnostic approach is needed. Since there is no specific guidelines available for the management of Kikuchi-Fujimoto disease, further studies are needed to conduct the therapeutic option and its long term outcome.

show abstract

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

A Rare Necrotizing Lymphadenitis: Kikuchi-Fujimoto Disease

Raj¹,

Ravi²,

Roshni³

et al. 2020

ijrps

View full text Add to dashboard Cite

show abstract

“…The histologically characteristic features of KFD: the presence of necrosis with a concentration of apoptotic cells in the central part of the lymph node; lack of neutrophils and eosinophils; occurrence on the periphery histiocytes, active lymphocytes, and plasmatic dendritic cells. 1,3,14 The histological structure of the nodes in KFD is similar to mononucleosis, tuberculosis, lymphoma, and SLE. However, there are visible differences in the histological structure, which allows distinguishing KFD from those diseases, as mentioned above.…”

Section: Diagnosticsmentioning

confidence: 98%

“…3 X-ray, CT or MRI examinations were performed to exclude other causes of lymphadenopathy, e.g., specific inflammation, lymphoma, or cancer metastasis. 1,3,10 However, the final diagnosis is based on the result of histological examination of biopsy samples from an enlarged lymph node. 10 There are three histological patterns of KFD: proliferative, necrotizing, and xanthomatous.…”

Section: Diagnosticsmentioning

confidence: 99%

Kikuchi-Fujimoto disease: State of the art

2021

View full text Add to dashboard Cite

Introduction: Kikuchi-Fujimoto disease (KFD), also called histiocytic necrotizing lymphadenitis, is a rare disease that occurs with swollen lymph nodes and associated fever. This disease occurs in both children and adults. Aim: The aim of our work was to review the literature and to remind family doctors, otolaryngologists, hematologists and rheumatologists about this rare disease that should be included in the differential diagnosis of long-term cervical lymphadenopathy. Material and methods: Current information on Kikuchi-Fujimoto disease was sought and presented based on literature that was published in reputable magazines in the period 2007–2020 in English. We searched for articles in the Medline, PubMed, and Scopus databases. Results and discussion: KFD occurs in both children and adults. This disease is found all over the world, most often in the Asian population. The etiology of Kikuchi-Fujimoto disease is not entirely known, however, two causal theories are suspected, which are discussed in detail in our article. The course of the disease is mild and usually disappears on its own. A biopsy of an involved lymph node presented as the standard for diagnosis. KFD treatment was causal – nonsteroidal anti-inflammatory drugs and/or glucocorticosteroids were used. Conclusions: There are few reports in the literature about Kikuchi-Fujimoto disease. KFD is associated with cervical lymphadenopathy and associated fever. If the diagnosis of the above-mentioned symptoms is not obvious, then in the differential diagnosis rarer diseases, such as KFD, should be included.

show abstract

“…Kikuchi-Fujimoto Disease (KFD) is the most common cause of histiocytic necrotizing lymphadenitis (non-granulomatous inflammation and necrosis of the lymph node), followed by systemic lupus erythematosus -SLE and acute Epstein Barr virus -EBV lymphadenitis [1,2]. It is a rare disease that was described for the first time in Japan, independently by Kikuchi and Fujimoto, in 1972 [1,2].…”

Section: Introductionmentioning

confidence: 99%

Kikuchi Fujimoto disease: A rare case of recurrence

Azevedo¹

2022

J Clin Images Med Case Rep

View full text Add to dashboard Cite

Background: Kikuchi-Fujimoto’s Disease (KFD) is rare, benign and more frequent in Asia. It is characterized by the appearance of lymphadenopathies and fever. Histological examination of the lymph nodes make the diagnosis. It is a self-limited disease. Relapses rarely occur. Case presentation: We described a case in Europe, with the particularity of having presented recurrence. Man, 66-year-old, leukodermic, admitted for weight loss, fever, multiple lymphadenopathies, hepato-splenomegaly, severe bicytopenia and acute kidney injury. Infectious, autoimmune and haematological diseases were excluded. Histological examination of cervical lymphadenopathy was compatible with necrotic KFD. After corticosteroid therapy, the condition resolved. Two years later, he was hospitalized for similar symptoms, hepato-splenomegaly, mediastinal and lumboaortic lymphadenopathies. Recurrence of KFD was admitted Conclusions: This case report is intended to alert to the difficulty of diagnosing a rare cause of lymphadenopathies in the western world. The diagnosis isn´t obvious, required the exclusion of other, much more frequent causes and whose treatment is more specific.

show abstract

Clinicopathologic spectrum of necrotizing lymphadenitis

Cited by 11 publications

References 8 publications

A Rare Necrotizing Lymphadenitis: Kikuchi-Fujimoto Disease

A Rare Necrotizing Lymphadenitis: Kikuchi-Fujimoto Disease

Kikuchi-Fujimoto disease: State of the art

Kikuchi Fujimoto disease: A rare case of recurrence

Contact Info

Product

Resources

About