Clinicopathologic Studies in Tympanosclerosis

Makishima, Kazumi; Toriya, Yoichi; Inoue, Shigetaka; Nakashima, Tadashi; Igarashi, Yoshiharu

doi:10.1097/00129492-198201000-00025

Cited by 8 publications

(13 citation statements)

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“…Congenital aural atresia presents as a spectrum from a minimally malformed middle ear with the majority of important structures present to cases in which the RW and OW are not discernable (11). Otosclerosis and tympanosclerosis present as a spectrum from minimal subclinical disease to obliteration of the OW and, in rare cases, the RW niche (12). Surgical management for these advanced cases carries a significant risk of sensorineural hearing loss (13).…”

mentioning

confidence: 99%

Third-Window Vibroplasty With an Active Middle Ear Implant

Lupo

Koka²,

Jenkins³

et al. 2012

Otology &Amp; Neurotology

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mentioning

confidence: 99%

Third-Window Vibroplasty With an Active Middle Ear Implant

Lupo

Koka²,

Jenkins³

et al. 2012

Otology &Amp; Neurotology

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“…Delayed resolution of inflammation often results in irreversible morphological changes in the epithelium, i.e. tympanosclerosis, which disturbs the function of the middle ear and causes conductive hearing loss [12,13]. Because we observed delayed resolution and sustained inflammation in a mouse model of OM with NTHi in PAI-1 KO mice, we investigated whether PAI-1 KO mice develop chronic OM with NTHi.…”

Section: Delayed Resolution Of Inflammation In Pai-1 Ko Mice Results mentioning

confidence: 99%

PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media

Shin

Koh²,

Woo³

et al. 2014

Acta Oto-Laryngologica

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NTHi up-regulated the expression of PAI-1 and tPA in the bullae of C57BL/6 mice, but not uPA. mRNA expression of IL-1β, TNFα, and MIP-2 was low in PAI-1 KO mice at early time points, but significantly higher at the later stage of OM. Similarly to the gene expression results, histological changes associated with OM were less at days 1 and 3 in PAI-1 KO mice. However, unlike the gradual resolution of OM pathologies in C57BL/6 mice, PAI-1 KO mice showed significant pathological changes of tympanosclerosis.

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“…The initial phase is characterized by injury of collagen fibrils caused by the inflammatory processes. The role of trapped and stagnating exudation is emphasized in this phase 1,4,5 . This initial phase is assumed to be reversible.…”

Section: Introductionmentioning

confidence: 99%

“…They are also known to be of significant importance for the normal remodeling processes. MMP activation and overexpression or the imbalance between active MMPs and the tissue inhibitors of metalloproteinases were found to be related to specific conditions accompanied by extracellular matrix remodeling and degradation as rheumatoid arthritis, periodontal diseases, tumor invasion, metastasis, arteriosclerosis, angiogenesis, and vascular processes such as aneurysm 5,8,10 …”

Section: Introductionmentioning

confidence: 99%

“…The role of trapped and stagnating exudation is emphasized in this phase. 1,4,5 This initial phase is assumed to be reversible. The second phase is a reparative one and is characterized by fibroblastic invasion leading to excessive collagenization and hyalinization which turns the tissue into a complex homogeneous mass with indiscernible fibrils.…”

Section: Introductionmentioning

confidence: 99%

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