Clinicopathologic studies of tansy ragwort toxicosis in ponies: sequential serum and histopathological changes

Craig, A. Morrie; Pearson, Erwin G.; Meyer, C; Schmitz, Jacob

doi:10.1016/s0737-0806(06)81312-2

Cited by 24 publications

(28 citation statements)

References 10 publications

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“…As diferentes respostas ou resistência individual dos animais aos AP podem refletir: 1) a detoxificação bacteriana no trato gastrintestinal, 2) a taxa de conversão, no fígado, dos AP a pirróis tóxicos e 3) a capacidade anti-oxidativa individual do animal. A quantidade de AP ingerida na alimentação também é importante (Craig et al 1991). Alguns autores consideram que as diferenças no metabolismo hepático dos ovinos são mais importantes do que a flora microbiana do rúmen.…”

Section: Mecanismos De Ação Sinais Clínicos E Patologia Dos Priunclassified

Patogênese, sinais clínicos e patologia das doenças causadas por plantas hepatotóxicas em ruminantes e eqüinos no Brasil

Santos

Riet-Correa²,

Simões³

et al. 2008

Pesq. Vet. Bras.

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Section: Mecanismos De Ação Sinais Clínicos E Patologia Dos Priunclassified

Patogênese, sinais clínicos e patologia das doenças causadas por plantas hepatotóxicas em ruminantes e eqüinos no Brasil

Santos

Riet-Correa²,

Simões³

et al. 2008

Pesq. Vet. Bras.

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“…Normalmente pode ocorrer um período de três a cinco meses entre o consumo da planta e o desenvolvimento dos sinais clínicos da doença (Curran et al 1996), porém, um estudo clinico-patológico da toxicose por Senecio jacobaea em pôneis evidenciou dois padrões clínicos da progressão da doença: um processo de hepatopatia crônica com morte em 6 a 22 semanas (2 a 5 meses); e um processo de doença crôni-ca retardada, onde os animais permanecem clinicamente normais até antes da morte em 38 a 58 semanas (9 a 14 meses). Os autores advertem que nestes casos tardios é necessá-rio que os veterinários fiquem atentos porque os animais apresentam-se normais, enquanto que a hepatopatia progressiva está ocorrendo (Craig et al 1991). Às vezes os animais apresentam recuperação quando retirados do pasto contendo plantas com AP (Gorder 2000).…”

Section: Discus Discus Discus Discus Discussão E Conclusões São E Conunclassified

“…Às vezes os animais apresentam recuperação quando retirados do pasto contendo plantas com AP (Gorder 2000). Porém na maioria das vezes, quando os sinais clínicos da toxicose por AP aparecem, os danos hepáticos são irreversíveis, havendo poucas exceções, onde os animais sobrevivem e apresentam melhoras na estrutura e nas funções hepática (Craig et al 1991). É importante que estes animais que sobrevivem sejam acompanhados periodicamente com exames de bioquímicos e biopsia hepática (Mendel et al 1988).…”

Section: Discus Discus Discus Discus Discussão E Conclusões São E Conunclassified

“…As diferentes respostas ou resistência individual dos animais as pirrolizidinas podem refletir: a detoxificação bacteriana no trato gastrintestinal; a taxa de conversão, no fígado, dos AP a pirróis tóxicos; e a capacidade anti-oxidativa individual do animal. A quantidade de AP ingerida na alimentação também é importante (Craig et al 1991).…”

Section: Discus Discus Discus Discus Discussão E Conclusões São E Conunclassified

“…Os AP são ativados por este sistema, onde causam danos e ocorre a liberação da GGT no soro (Curran et al 1996). Em pôneis intoxicados experimentalmente com Senecio jacobaea a GGT foi o teste enzimático mais seguro para indicar o começo e a continuidade das alterações hepáticas (Craig et al 1991). A elevação desta enzima foi documentada também em eqüinos com intoxicação natural e experimental por Senecio jacobaea (Giles 1983, Garret et al 1984, Gorder 2000, Senecio vulgaris (Gulick et al 1980, Lessard et al 1986, Mendel et al 1988 e Cynoglossum officinale (Knight et al 1984).…”

Section: Discus Discus Discus Discus Discussão E Conclusões São E Conunclassified

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Intoxicação por Crotalaria retusa (Fabaceae) em Eqüídeos no semi-árido da Paraíba

et al. 2004

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were observed in horses on 8 farms in the semiarid region of Paraíba and Ceará. C. retusa was found in all farms. The main clinical signs were characteristic of hepatic encephalopathy, with dullness or hyperexcitability, head pressing, compulsive walking or circling and, occasionally, violent uncontrollable galloping. Decreased cranial nerve reflexes, ataxia and weakness were also observed. Other clinical signs were anorexia, weight loss, photosensitization and jaundice. The clinical manifestation period varied from 4 to 40 days, but most horses had a previous history of weight loss. At necropsy the livers were hard, with irregular surface and white areas mixed with dark red areas and increased lobular pattern. Mild jaundice, ascitis, hydropericardium and hydrothorax were also observed. Edema and moderate congestion were seen in the lungs. Histologic changes of the liver were characterized by fibrosis, mainly periportal, megalocitosis and bile duct cell proliferation. Multifocal areas of centrilobular or midzonal hemorrhages were also observed. Centrilobular hemorrhagic necrosis was present in two horses. Alzheimer type II astrocytes were observed, isolated or in groups, mainly in the caudate nucleus and cortex in 4 horses. The poisoning was experimentally produced in 1 adult horse and 3 adult donkeys. The horse received daily 100 g of C. retusa seeds and died 52 days after the beginning of the experiment. The dried whole C. retusa was mixed with grass and given to the 3 experimental donkeys at daily doses of 10g/kg, 5g/kg and 2.5g/kg, respectively. The donkey treated with 5g per kg died 48 days after beginning of the experiment and the other two were sacrificed at 120 days. Clinical signs and pathology were similar to those observed in spontaneous cases, but Alhzeimer type II astrocytes were observed only in the donkey that died 48 days after the beginning of ingestion of the plant material. The concentration of monocrotaline in the whole plant given to the donkeys was 0.5%.INDEX TERMS: Poisonous plants, plant poisoning, Crotalaria retusa, Fabaceae, hepatic cirrhosis, horse, pirrolizidine alkaloids.

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Metabolic profiles of cow's blood; a review

2016

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The term 'metabolic profile' refers to the analysis of blood biochemical parameters that are useful to assess and prevent metabolic and nutritional disorders in dairy herds. In the higher standards of milk production, the priority in modern breeding is keeping dairy cows in high lactation and healthy. The proper analysis, as well as control. of their feeding and metabolic status is immensely important for the health condition of the herd. The disproportion between the genetically determined ability for milk production and the limitations in improving the energy value of the ration may be the cause of metabolic disorders. Negative energy balance has a major impact on the body's hormonal balance and organ functions and mostly appears during transition periods: from 3 to 2 weeks prepartum until 2-3 weeks postpartum. The term 'transition' is used to underscore the important physiological, metabolic and nutritional changes occurring in this time. The manner in which these changes occur and how they are diagnosed and detected are extremely important, as they are closely related to clinical and subclinical postpartum diseases, lactation and reproductive performance - factors that significantly shape the profitability of production. Therefore the priority for intensive milk production is prevention of metabolic diseases and other disorders. It is the intent of this review to synthesize and summarize the information currently available on metabolic status and physiological changes in the cow's body that occur during lactation, as well as to discuss the interpretation of the results, which will be a useful diagnostic tool in nutritional evaluations of the dairy herd. © 2016 Society of Chemical Industry.

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Clinicopathologic studies of tansy ragwort toxicosis in ponies: sequential serum and histopathological changes

Cited by 24 publications

References 10 publications

Patogênese, sinais clínicos e patologia das doenças causadas por plantas hepatotóxicas em ruminantes e eqüinos no Brasil

Patogênese, sinais clínicos e patologia das doenças causadas por plantas hepatotóxicas em ruminantes e eqüinos no Brasil

Intoxicação por Crotalaria retusa (Fabaceae) em Eqüídeos no semi-árido da Paraíba

Metabolic profiles of cow's blood; a review

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