Clinicopathological analysis of 232 radicular cysts of the jawbone in a population of southern Taiwanese patients

Abstract

This retrospective study aimed to evaluate the clinicopathological features of 232 cases of radicular cyst (January 2001-December 2016) submitted for histopathological examination to Department of Oral Pathology by endodontists in our institution. Demographic data including age, gender, affected site, involved tooth, and histopathological features, were reviewed. The study population comprised 133 females (57.3%) and 99 males (42.7%), with a mean age of 40.5 years and an age range of 13-78 years. Two-hundred and one cysts occurred in the maxilla (86.7%) and 31 in the mandible (13.3%). Most cases involved the anterior teeth of the maxilla (67.2%). The most frequently-involved tooth was the maxillary lateral incisor (50.5%). In most cases (228 cases; 98.3%), the cyst was lined with nonkeratinized stratified squamous epithelium, with two cases containing epithelial lining of the mucoepidermoid epithelium (0.9%) and respiratory epithelium (0.9%), respectively. One case (0.4%) revealed epithelial dysplasia of the epithelial lining. Hyaline body was seen in two cases (0.9%), and Rushton body was noted in seven cases (3.0%). Odontogenic epithelial rest was noted in one case (0.4%). Cholesterol clefts (54 cases; 23.3%), foamy histiocytes (72 cases; 31.0%), hemosiderins (57 cases; 24.6%), dystrophic calcifications (94 cases; 40.5%), foreign bodies (44 cases; 19.0%), and bacterial colonies (22 cases; 9.5%) were also observed. Fifty-three cases (22.8%) showed a mixed acute and chronic inflammatory infiltrate, whereas chronic inflammatory infiltrate only was noted in 179 cases (77.2%). In summary, the current findings provide a valuable source for clinicopathological reference concerning radicular cysts of the jawbone.

Clinicopathological Study of 72 Periapical Lesions from Vietnamese Patients

“…1,8 The origin of foreign bodies in the present study came from root canal filling materials, which was in agreement with the two previous studies. 8,25 In the present study, only two cases (4.4%) of periapical granuloma were diagnosed with mixed acute and chronic inflammation, a much lower frequency than that reported by Lin et al 8 No mixed acute and chronic inflammation was found in a periapical cyst, which was in contrast to the results in Lin et at. 8 and Chen et al 25 Regarding biopsy samples exhibiting chronic inflammation only, the incidence of chronic inflammation in the periapical granulomas was highest with mild chronic inflammation, followed by moderate and severe inflammation, which was in contrast to Lin et al 8 who found that moderate inflammation was the most frequent, followed by severe and mild inflammation.…”

“…8,25 In the present study, only two cases (4.4%) of periapical granuloma were diagnosed with mixed acute and chronic inflammation, a much lower frequency than that reported by Lin et al 8 No mixed acute and chronic inflammation was found in a periapical cyst, which was in contrast to the results in Lin et at. 8 and Chen et al 25 Regarding biopsy samples exhibiting chronic inflammation only, the incidence of chronic inflammation in the periapical granulomas was highest with mild chronic inflammation, followed by moderate and severe inflammation, which was in contrast to Lin et al 8 who found that moderate inflammation was the most frequent, followed by severe and mild inflammation. In periapical cysts, moderate inflammation was the most common, followed by severe and mild inflammation, with a similar frequency of cases as reported by Lin et al, 8 but differed with Chen et al 25…”

“…2 Dystrophic calcification and foamy histiocytes were present in 30 cases (57%) and in 13 cases (40.7%), respectively, which was more frequent compared with other studies. 8,25 We identified foreign bodies in one (3.7%) periapical cyst lesion case, which was higher than that of 0.4% reported by Stockdale and Chandler, 12 but lower than other reports. 1,8 The origin of foreign bodies in the present study came from root canal filling materials, which was in agreement with the two previous studies.…”

Tunnel’ radicular cyst and its management with root canal treatment and periapical surgery: A case report

“…10 Histopathological analyses in a study reported that, nonkeratinized stratified squamous epithelial lining was found in 98.3% of the radicular cysts, while both mucoepidermoid epithelium and respiratory epithelium were found in 0.9% of the cases, followed by one case (0.4%) which revealed epithelial dysplasia of the epithelial lining. 11 The treatment of choice may be determined by multiple factors such as lesion extension and its clinical characteristic, the involvement of important anatomical structures, patient preference and their systemic condition. Most radicular cysts can be managed with conventional root canal treatment without a surgical approach.…”

“…Surgical biopsy and histopathological evaluation remain the standard procedures for differentiating radicular cysts from other periapical pathologies 10 . Histopathological analyses in a study reported that, nonkeratinized stratified squamous epithelial lining was found in 98.3% of the radicular cysts, while both mucoepidermoid epithelium and respiratory epithelium were found in 0.9% of the cases, followed by one case (0.4%) which revealed epithelial dysplasia of the epithelial lining 11 …”