Clinicopathological Analysis of DU-PAN-2 as a Tumor Marker for Endometrial Adenocarcinoma in Comparison with CA19-9.

Serum carbohydrate antigen elevations in endometrial adenocarcinomas: Characterization of DU‐PAN‐2 expression as a tumor marker

“…CA125 is well known as a useful tumor marker for variable gynecologic malignancies, although it cannot specify the disease. Recently, we reported the clinicopathologic availability of DU‐PAN‐2 in comparison with CA19‐9, based on immunohistochemical and serologic analysis 1 . In that study, the relationship between immunohistochemical expression profiles and serological expression profiles was found to be closer for DU‐PAN‐2 than for CA19‐9.…”

“…CV(%) of these markers was as follows; DU‐PAN‐2 intra 5.6, inter 7.6; CA19‐9 intra 6.0, inter 6.1; Lewis x intra 7.8, inter 10.8; CA125 intra 1.5, inter 1.5. The positive/negative cutoff values for serum DU‐PAN‐2 and CA19‐9 were set at DU‐PAN‐2, 74.0 U/mL; CA19‐9, 38.0 U/mL, based on the (mean + 2 × SD) from benign uterine lesions 1,7 . As for sialyl Lewis x and CA125, 8.0 U/mL and 35.0 U/mL were used as the cutoff values, respectively 8,9 .…”

“…Subsequently, we reported that immunohistochemical expression of DU‐PAN‐2 was more frequent than that of CA19‐9 in EMACs of various grades, with no correlation to menopausal status 3 . Unlike serum CA19‐9 that fails to be elevated in Lewis negative patients, DU‐PAN‐2 seems to have the advantage of availability in EMACs of any Lewis blood group phenotype 1 . In addition, we mentioned that the analysis of DU‐PAN‐2 expression in variable organs or neoplastic disorders would provide interesting findings from the histologic and clinical points of view 4,5 …”

“…Our latest study led us to believe that some endometrial adenocarcinomas (EMACs) have the potential to produce DU‐PAN‐2 in comparison with the benign uterine lesions, leiomyoma and adenomyosis, and that DU‐PAN‐2 could be added into a panel of tumor markers for EMACs 1 . Prior to the study, our immunohistochemical analyses demonstrated that DU‐PAN‐2 and CA19‐9 expressions in the normal endometrium were strongly dependent on hormonal regulation during the menstrual cycle 2 .…”

An image processing algorithm for single-photon fluorescent tomography under conditions of strong scattering

“…The dyes used in oncology are selectively accumulated in cancer cells; they start to fluoresce under laser irradiation [10]. The fluorescence intensity depends on the dye content and exciting radiation intensity.…”