2018
DOI: 10.3892/ol.2018.8530
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Clinicopathological analysis of epithelioid inflammatory myofibroblastic sarcoma

Abstract: Abstract. Inflammatory myofibroblastic tumor (IMT) is a distinctive neoplasm composed of myofibroblastic and fibroblastic spindle cells, accompanied by the inflammatory infiltration of plasma cells, lymphocytes and/or eosinophils. Epithelioid inflammatory myofibroblastic sarcoma (EIMS), which primarily consists of cells with a round or epithelioid morphology, is associated with a poor prognosis and rapid development of local recurrence, and has been recognized to be a variant of IMT. Diagnosis of EIMS is diffi… Show more

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Cited by 18 publications
(32 citation statements)
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“…EIMS is a rare variant of IMT, which is clinically distinct from conventional cases in that it follows an aggressive clinical course and has a high mortality rate ( 6 ). EIMS predominantly originates intraabdominally, with most cases arising in the omentum and mesentery, and adult males appear to be more susceptible to EIMS ( 7 ). There are some common features observed in patients with EIMS, including round-to-epithelioid tumor cells, abundant myxoid stroma with inflammatory infiltrates composed primarily of neutrophils, immuno-positivity for nuclear membrane ALK staining, RANBP2-ALK gene fusion and Des positive staining ( 7 , 8 ).…”
Section: Discussionmentioning
confidence: 99%
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“…EIMS is a rare variant of IMT, which is clinically distinct from conventional cases in that it follows an aggressive clinical course and has a high mortality rate ( 6 ). EIMS predominantly originates intraabdominally, with most cases arising in the omentum and mesentery, and adult males appear to be more susceptible to EIMS ( 7 ). There are some common features observed in patients with EIMS, including round-to-epithelioid tumor cells, abundant myxoid stroma with inflammatory infiltrates composed primarily of neutrophils, immuno-positivity for nuclear membrane ALK staining, RANBP2-ALK gene fusion and Des positive staining ( 7 , 8 ).…”
Section: Discussionmentioning
confidence: 99%
“…EIMS predominantly originates intraabdominally, with most cases arising in the omentum and mesentery, and adult males appear to be more susceptible to EIMS ( 7 ). There are some common features observed in patients with EIMS, including round-to-epithelioid tumor cells, abundant myxoid stroma with inflammatory infiltrates composed primarily of neutrophils, immuno-positivity for nuclear membrane ALK staining, RANBP2-ALK gene fusion and Des positive staining ( 7 , 8 ). In IMTs, inflammatory infiltrates are composed primarily of plasma cells and lymphocytes ( 3 ), immuno-positive staining for ALK expression is predominantly observed in the cytoplasm and membrane ( 9 ), and SMA expression is more commonly observed than Des ( 3 ).…”
Section: Discussionmentioning
confidence: 99%
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“…2 It is often intra-abdominal and clinicopathologically different from conventional IMT in that it is more aggressive with a higher rate of recurrence and poorer prognosis. 3 It is mainly composed of plump round to epithelioid or histiocytoid tumor cells with a minor spindle cell component. Cells are arranged in clusters or non-cohesive sheets within a stroma, which is frequently myxoid.…”
Section: Introductionmentioning
confidence: 99%