Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis

Miao, Chenkui; Zhao, Kai; Zhu, Jingjing; Liang, Chao; Xu, Aiming; Hua, Yingqi; Zhang, Jianzhong; Liu, Shouyong; Tian, Ye; Zhang, Chao; Wang, Yuhao; Su, Shifeng; Wang, Zengjun; Liu, Bianjiang

doi:10.1155/2017/6010721

Cited by 3 publications

(4 citation statements)

References 36 publications

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“…Most importantly, only STAiR18 showed a global overexpression in various cancer types [8]. This observation has since been confirmed by further publications [11][12][13]. Therefore, our preliminary data supported the view that STAiR18 contributes to STAT3-dependent tumorigenesis in multiple myeloma as well as in other cancer entities [8].…”

Section: Introductionsupporting

confidence: 87%

Master and servant: LINC00152 – a STAT3-induced long noncoding RNA regulates STAT3 in a positive feedback in human multiple myeloma

et al. 2020

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Background: The survival of INA-6 human multiple myeloma cells is strictly dependent upon the Interleukin-6activated transcription factor STAT3. Although transcriptional analyses have revealed many genes regulated by STAT3, to date no protein-coding STAT3 target gene is known to mediate survival in INA-6 cells. Therefore, the aim here was to identify and analyze non-protein-coding STAT3 target genes. In addition to the oncogenic microRNA-21, we previously described five long noncoding RNAs (lncRNAs) induced by STAT3, named STAiRs. Here, we focus on STAT3-induced RNA 18 (STAiR18), an mRNA-like, long ncRNA that is duplicated in the human lineage. One STAiR18 locus is annotated as the already well described LINC00152/CYTOR, however, the other harbors the MIR4435-2HG gene and is, up to now, barely described.Methods: CAPTURE-RNA-sequencing was used to analyze STAiR18 transcript architecture. To identify the STAiR18 and STAT3 phenotype, siRNA-based knockdowns were performed and microarrays were applied to identify their target genes. RNA-binding partners of STAiR18 were determined by Chromatin-Isolation-by-RNA-Purification (ChIRP) and subsequent sequencing. STAT3 expression in dependence of STAiR18 was investigated by immunoblots, chromatin-and RNA-immunoprecipitations. Results: As identified by CAPTURE-RNA sequencing, a complex splice pattern originates from both STAiR18 loci, generating different transcripts. Knockdown of the most abundant STAiR18 isoforms dramatically decreased INA-6 cell vitality, suggesting a functional role in myeloma cells. Additionally, STAiR18 and STAT3 knockdowns yielded overlapping changes of transcription patterns in INA-6 cells, suggesting a close functional interplay between the two factors. Moreover, Chromatin isolation by RNA purification (ChIRP), followed by genome-wide RNA sequencing showed that STAiR18 associates specifically with the STAT3 primary transcript. Furthermore, the knockdown of STAiR18 reduced STAT3 levels on both the RNA and protein levels, suggesting a positive feedback between both molecules. Furthermore, STAiR18 knockdown changes the histone methylation status of the STAT3 locus, which explains the positive feedback and indicates that STAiR18 is an epigenetic modulator.

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Section: Introductionsupporting

confidence: 87%

Master and servant: LINC00152 – a STAT3-induced long noncoding RNA regulates STAT3 in a positive feedback in human multiple myeloma

et al. 2020

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“…66,67 A metaanalysis of eight trials unveiled strong correlations between linc00152 and the diagnosis, prognosis, and metastasis of cancers, particularly lymph node metastases. 68 A recent metaanalysis of the data for 913 cancer patients further confirmed the diagnostic utility of linc00152 as well as its association with lymph node metastases, advances in the TNM stage, and shorter overall survival. 69 Because many studies have revealed the mechanisms underlying linc00152 effects in diverse cancers (Table 1), linc00152 or the molecules associated with its activities represent candidate therapeutic targets.…”

Section: Linc00152 Expression May Be Useful For Diagnosing and Predmentioning

confidence: 89%

“…Several meta‐analyses have verified the application of linc0012 as a biomarker for diagnosing cancers . A meta‐analysis of eight trials unveiled strong correlations between linc00152 and the diagnosis, prognosis, and metastasis of cancers, particularly lymph node metastases . A recent meta‐analysis of the data for 913 cancer patients further confirmed the diagnostic utility of linc00152 as well as its association with lymph node metastases, advances in the TNM stage, and shorter overall survival .…”

Section: Clinical Application Of Linc00152 In Cancersmentioning

confidence: 93%

Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies

Guo

Jiang

et al. 2019

Cancer Medicine

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Linc00152, located on chromosome 2p11.2, is a long intergenic non‐coding RNA molecule with 828 nucleotides that is highly expressed in many types of human tumor tissues, especially in malignant tumors of the digestive system. Linc00152 promotes the occurrence and development of tumors by increasing tumor cell proliferation, invasion, metastasis, and apoptosis. Additionally, linc00152 contributes to the carcinogenesis of several cancers, including gastric cancer, liver cancer, hepatocellular carcinoma, gallbladder cancer, clear cell renal cell carcinoma, and colorectal cancer, by disturbing various signaling pathways (eg PI3K/AKT, mTOR, IL‐1, and NOTCH 1 signaling pathways). High linc00152 expression levels are associated with chemoresistance as well as poor prognosis and shorter survival. Continual advances made in the relevant research have indicated that linc00152 may be useful as a new tumor molecular biomarker, applicable for tumor diagnosis, targeted therapy, and prognosis assessment. This review summarizes the progress in the research into the relationship between linc00152 and the occurrence and development of malignancies based on molecular functions, regulatory mechanisms, and clinical applications.

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“…We also detected significant downregulation of MIR155HG, whose high expression is associated with glioma progression and poor survival [52]. Another downregulated lncRNA with relevance to prognosis is linc000152, whose increased expression has been observed in multiple tumor types [53,53]. On the other hand, we observed a significant upregulation of two "oncogenic" lncRNAs, NEAT1 and FTX.…”

Section: Resultsmentioning

confidence: 54%

Integrated analyses of early responses to radiation in glioblastoma identify new alterations in RNA processing and candidate target genes to improve treatment outcomes

Choudhary

Burns

Mirsafian

et al. 2019

Preprint

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Background: High-dose radiation is the main component of glioblastoma therapy. Unfortunately, radioresistance is a common problem and a major contributor to tumor relapse. Understanding the molecular mechanisms driving response to radiation is critical for identifying regulatory routes that could be targeted to improve treatment response. Methods:We conducted an integrated analysis in the U251 and U343 glioblastoma cell lines to map early alterations in the expression of genes at three levels: transcription, splicing, and translation in response to ionizing radiation.Results: Changes at the transcriptional level were the most prevalent response. Downregulated genes are strongly associated with cell cycle and DNA replication and linked to a coordinated module of expression.Alterations in this group are likely driven by decreased expression of the transcription factor FOXM1 and members of the E2F family. Genes involved in RNA regulatory mechanisms were affected at the mRNA, splicing, and translation levels, highlighting their importance in radiation-response. We identified a number of oncogenic factors, with an increased expression upon radiation exposure, including BCL6, RRM2B, IDO1, FTH1, APIP, and LRIG2 and lncRNAs NEAT1 and FTX. Several of these targets have been previously implicated in radioresistance. Therefore, antagonizing their effects post-radiation could increase therapeutic efficacy. Conclusions:Our integrated analysis provides a comprehensive view of early response to radiation in glioblastoma. We identify new biological processes involved in altered expression of various oncogenic factors and suggest new target options to increase radiation sensitivity and prevent relapse.

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Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis

Cited by 3 publications

References 36 publications

Master and servant: LINC00152 – a STAT3-induced long noncoding RNA regulates STAT3 in a positive feedback in human multiple myeloma

Master and servant: LINC00152 – a STAT3-induced long noncoding RNA regulates STAT3 in a positive feedback in human multiple myeloma

Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies

Integrated analyses of early responses to radiation in glioblastoma identify new alterations in RNA processing and candidate target genes to improve treatment outcomes

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