Clinicopathological and Prognostic Roles of STAT3 and Its Phosphorylation in Glioma

Abstract

Glioma is defined as a common brain tumor which causes severe disability or death. As many genes are reported to relate with glioma’s occurrence and development, their prognostic and therapeutic value still remains uncertain. This study aimed at investigating the association between STAT3/p-STAT3 and glioma prognosis. Nine studies (12 trials) scored ≥5 on the Newcastle-Ottawa scale were meta-analysed from the Medline, Embase, and Web of Science databases. We found that STAT3/p-STAT3 overexpression in glioma patients was associated with worse overall survival ( hazard ratio HR = 1.40 , 95 % confidence interval CI = 1.05 ~ 1.86 , P = 0.020 ), progression-free survival ( HR = 2.05 , 95 % CI = 1.63 ~ 2.58 , P < 0.001 ), and better recurrence-free survival ( HR = 0.37 , 95 % CI = 0.15 ~ 0.95 , P < 0.039 ). Subgroup analysis implied that STAT3/p-STAT3 overexpression was associated with worse OS in standard treatment ( HR = 1.80 , 95 % CI = 1.06 ~ 3.04 , P = 0.030 ), and in China ( HR = 2.18 , 95 % CI = 1.77 ~ 2.70 , P < 0.001 ), and metaregression analysis indicated countries ( P = 0.001 ) may be the source of heterogeneity in our study. In conclusion, we suggested STAT3/p-STAT3 was associated with poor prognosis in patients with glioma, which indicated that STAT3/p-STAT3 might be a valuable prognostic biomarker and a promising therapeutic target for glioma.

Construction of a novel radiosensitivity- and ferroptosis-associated gene signature for prognosis prediction in gliomas

“…Furthermore, Tang et al revealed that HSPB1 was crucial in ferroptosis-mediated cancer therapy 34 . STAT3 was associated with poor prognosis in gliomas 35 . Bao et al demonstrated that Ibrutinib could inactivate STAT3, thus reducing radiation resistance in glioma cells.…”

Wild‑type KRAS inhibits the migration and invasion of pancreatic cancer through the Wnt/β‑catenin pathway

“…regulates cell proliferation, differentiation and metastasis (31,32). Studies have shown that STaT3/p-STaT3 is highly expressed in a variety of tumors and its activation product, p-STaT3, is associated with tumor grade and patient prognosis (33,34).…”

“…MMP-3 can activate MMP-1 and other family members and its overexpression is associated with the growth and metastasis of various cancers, including breast cancer ( 30 ). When stimulated by external signals, STAT3 migrates to the nucleus in the form of activated p-STAT3, which stimulates cell growth and angiogenesis, activates the transcription of target genes and regulates cell proliferation, differentiation and metastasis ( 31 , 32 ). Studies have shown that STAT3/p-STAT3 is highly expressed in a variety of tumors and its activation product, p-STAT3, is associated with tumor grade and patient prognosis ( 33 , 34 ).…”

Wild kras inhibit the migration and invasion of pancreatic cancer through Wnt /β-catenin pathway

“…Signal transduction and transcriptional activator 3(STAT3), a member of the STAT family, is the most critical in the STATS signaling pathway family. When stimulated by external signals, STAT3 migrates to the nucleus in the form of activated phosphorylated STATA3 (p-STATA3), which stimulates cell growth and angiogenesis, activates the transcription of target genes, and regulates cell proliferation, differentiation, and metastasis [24,25] . Studies have shown that STAT3/p-STAT3 is highly expressed in a variety of tumors, and its activation product, p-STAT3, is associated with tumor grade and patient prognosis [26,27] .…”