Clinicopathological characteristics and prognosis of breast cancer with special histological types: A surveillance, epidemiology, and end results database analysis

Abstract

Objectives To explore the clinicopathological features and prognosis of breast cancer with special histological types. Materials and methods The information of breast cancer patients was obtained from the Surveillance, Epidemiology, and End Results (SEER) database (2010–2016). Comparative analyses were performed to explore the difference in clinicopathological characteristics and propensity score matching (PSM) was used to weaken the effects from clinical profiles. Survival analysis was conducted to investigate the prognostic effects from histological types, and the prognostic factors of this group of patients were identified with the univariate COX proportional model. Results A total of 242863 breast cancer patients were eligible, of which 230213 individuals were ductal breast cancer (IDC) and 12650 individuals were special breast lesions, respectively. Comparatively, special breast cancer had a lower histological grade, a smaller tumor size, a lower proportion of nodal involvement and distant metastasis, in addition to a higher proportion of triple-negative subtype. The overall prognosis of special histological breast cancer was comparable to IDC, while the survival of HER2 enriched breast cancer was in favor of special breast cancer. With the PSM performance, the prognosis exhibited an inferior profile in the metaplastic breast cancer and was significantly favorable to apocrine, medullary, micropapillary, and papillary breast cancer. Conclusion This study revealed that the special histological breast cancer presented distinct clinicopathological characteristics and great heterogeneity in the prognosis among diverse histological subtypes.

Clinicopathological Characteristics and Prognosis of Squamous Cell Carcinoma of the Breast: A Population-Based Analysis

“…Risk factors for SCC were identified, including older age, advanced disease TNM stage, and organ involvement, which were similar to the data reported by prior studies focusing on breast cancer with other histologic types. 14,15 Our study highlighted the substantial heterogeneity in the clinical features of breast cancer with squamous differentiation. Currently, clinical trials designed for breast cancer tend to ignore the histological classifications, which probably results in bias regarding clinical significance.…”

“…Risk factors for SCC were identified, including older age, advanced disease TNM stage, and organ involvement, which were similar to the data reported by prior studies focusing on breast cancer with other histologic types. 14 , 15 …”

Unique clinicopathological characteristic and survival rate of metaplastic breast cancer;a special subtype of breast cancer a 5 year cohort study in single referral centre in North Borneo

“…This finding are consistent with NCCN (National Comprehensive Cancer Network 2020 guideline) where it mention that MBC are highly unusual to have ER positive biology. Triple negative subtype of MBC revealed inferior outcome and poorer prognosis when compared to their invasive ductal carcinoma counterparts [ 1 ]. This brings about limited potential of targeted therapies for patients diagnosed with MBC.…”

“…Metaplastic breast carcinoma (MBC) is a rare type of breast carcinoma and is well recognised for its heterogeneity and worse prognosis compared to the other types of breast carcinoma [ [1] , [2] , [3] ]. Previous studies reported incidence of MBC of less than 1% of all types of breast carcinoma.…”

Evaluation of Adjuvant Treatments for Adenoid Cystic Carcinoma of the Breast: A Population-Based, Propensity Score Matched Cohort Study from the SEER Database

“…In addition, no statistically significant difference existed in OS between ACC and MC, which was favorable histology and generally ER positive and Her2 negative [ 12 , 13 ]. Given its rarity and good prognosis, the value of adjuvant therapy in patients with ACC of the breast remained controversial and led to large variations in clinical practice [ 8 , 14 ].…”