Clinicopathological characteristics of breast cancer and trends in the management of breast cancer patients in Japan: Based on the Breast Cancer Registry of the Japanese Breast Cancer Society between 2004 and 2011

Kurebayashi, Junichi; Miyoshi, Yasuo; Ishikawa, Takashi; Saji, Shigehira; Sugie, Tomoharu; Suzuki, Takashi; Takahashi, Shunji; Nozaki, Miwako; Yamashita, Hiroko; Tokuda, Yutaka; Nakamura, Seigo

doi:10.1007/s12282-015-0599-6

Cited by 63 publications

(54 citation statements)

References 18 publications

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“…The rate of HER2 positivity of 37% found in microinvasive carcinoma in the present study was higher compared with the rates of earlier reports on invasive breast cancer in Japanese (12%–15%) 22 23. The characteristics found for HER2-positive microinvasive breast cancer can be summarised as follows: (1) high grade; (2) large comedo (>450 µm); (3) high TIL and CD8+ TIL; (4) healing phenomenon and (5) high rate of cluster-like invasion.…”

Section: Discussioncontrasting

confidence: 87%

Two progressive pathways of microinvasive carcinoma: low-grade luminal pathway and high-grade HER2 pathway based on high tumour-infiltrating lymphocytes

et al. 2016

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Our study revealed that microinvasive carcinoma has two progressive pathways; 'low-grade luminal pathway' and 'high-grade HER2 pathway'. HER2-positive cases showed the following unique characteristics: 'high-grade; comedo, high TIL and CD8+ TIL; healing; cluster-like invasion'. These results suggest that the cluster-like invasion might occur because of tumour immunity that leads to disruption of the duct and formation of microinvasive carcinoma in HER2-positive cases.

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Section: Discussioncontrasting

confidence: 87%

Two progressive pathways of microinvasive carcinoma: low-grade luminal pathway and high-grade HER2 pathway based on high tumour-infiltrating lymphocytes

et al. 2016

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“…In addition, the JBCS Registry reported that the proportions of ER and PgR positivity were 75.7% and 62.3% among those registered in 2005, respectively 11 . Furthermore, with respect to histological type of breast cancer, the JBCS Registry reported proportions of 82.9%, 8.2% and 8.9% for invasive carcinoma, non-invasive ductal carcinoma and remaining types (including non-invasive lobular carcinoma and special and other types), respectively, among breast cancer patients registered in 2004 20 . Our results were in accordance with the results of this relevant registry.…”

Section: Discussionmentioning

confidence: 97%

Characteristics and prognosis of Japanese female breast cancer patients: The BioBank Japan project

Nakamura

Okada

Ukawa

et al. 2017

Journal of Epidemiology

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BackgroundBreast cancer is currently the most common type of cancer in Japanese females. Unlike most other types of cancer, breast cancer develops more frequently in middle-aged females than in elderly females.MethodsOf all Japanese female breast cancer patients aged ≥20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 2034 were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry. Furthermore, we examined the effect of these characteristics on all-cause mortality.ResultsIn the female patients registered within 90 days after diagnosis, the frequency of stage 0 or unclassified, stage I, II, III and IV were 11.4%, 47.9%, 37.0%, 2.9% and 0.8%, respectively. The proportion of histological types was 12.9% for non-invasive carcinoma (ductal carcinoma and lobular carcinoma), 81.0% for invasive carcinoma (papillotubular carcinoma, solid tubular carcinoma, scirrhous carcinoma and special types), 0.2% for Paget's diseases and 5.8% for others. Those positive for the estrogen and progesterone receptors accounted for 75.8% and 62.1% of all patients, respectively. Among 1860 female participants registered within 90 days, 218 participants died during 144,54 person-years of follow-up. More advanced stage, elevation of serum carcinoembryonic antigen and carbohydrate antigen 15-3 levels and absence of the estrogen receptor at study entry were crudely associated with an increased risk of all-cause mortality after adjustment for age.ConclusionsThis study showed the association of several clinical characteristics with all-cause mortality in female breast cancer patients.

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“…In addition, studies on breast cancer in Japan between 2004 and 2011 showed that although the annual rates of patients treated with BCS increased until 2006, this increase stopped in 2007 and plateaued at approximately 60% thereafter. The proportion of modified radical mastectomy steadily decreased between 2004 and 2011 while that of simple mastectomy increased during the same period [22]. …”

Section: Discussionmentioning

confidence: 99%

Basic Facts of Breast Cancer in Korea in 2014: The 10-Year Overall Survival Progress

et al. 2017

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We, the Korean Breast Cancer Society (KBCS), present the facts and the trends of breast cancer in Korea in 2014. Data on the total number of newly diagnosed patients was obtained from the Korea Central Cancer Registry database, other data were collected from the KBCS online registry database, and the overall survival data of patients were updated from Statistics Korea. A total of 21,484 female patients were newly diagnosed with breast cancer in 2014. The crude incidence rate and the age-standardized incidence rate (ASR) of breast cancer in female patients, including carcinoma in situ, were 83.4 cases and 63.9 cases per 100,000 women, respectively. The ASR showed an annual increase of 6.1% from 1999 to 2014; however, although the increase of the ASR had slowed since 2008, the incidence rate itself continuously increased. The proportion of early breast cancer increased consistently, and the pathological features changed accordingly. While breast-conserving surgery was mainly performed, the proportion of total mastectomy was slightly increased. The total number of breast reconstruction surgeries increased rapidly. The 5-year and 10-year overall survival rates for all stages of breast cancer patients were 91.2% and 84.8%, respectively. The overall survival rate of Korean patients with breast cancer was extremely high, compared with other developed countries. Thus, we consider that the clinical characteristics of breast cancer have changed over the past decade. A nationwide registry data will contribute to a better understanding of the characteristics of breast cancer in Korea.

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Clinicopathological characteristics of breast cancer and trends in the management of breast cancer patients in Japan: Based on the Breast Cancer Registry of the Japanese Breast Cancer Society between 2004 and 2011

Cited by 63 publications

References 18 publications

Two progressive pathways of microinvasive carcinoma: low-grade luminal pathway and high-grade HER2 pathway based on high tumour-infiltrating lymphocytes

Two progressive pathways of microinvasive carcinoma: low-grade luminal pathway and high-grade HER2 pathway based on high tumour-infiltrating lymphocytes

Characteristics and prognosis of Japanese female breast cancer patients: The BioBank Japan project

Basic Facts of Breast Cancer in Korea in 2014: The 10-Year Overall Survival Progress

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