Clinicopathological Correlates: Chronic Arsenic Toxicity Causing Bilateral Symmetric Progressive Optic Neuropathy

Freund, Paul R.; Alshafai, Laila; Mankovskii, Gabriella; Howarth, D. J.; Margolin, Edward

doi:10.1097/wno.0000000000000961

“…Peripheral neuropathy related to As exposure through drinking water was also reported in other studies [67,68]. As contaminated drinking water may also cause optic neuropathy [69,70]. Li et al (2020) explored the accumulation of As in various murine tissues, including different regions of the brain.…”

Section: Arsenicmentioning

confidence: 54%

Trace elements concentrations in drinking water – is there a risk for neurological or psychiatric disorders?

Januszewski,

Forma,

Sitarz

et al. 2023

Curr Probl Psychiatry

0

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Introduction: Drinking water contaminated with heavy metals like arsenic, cadmium, nickel, mercury, chromium, zinc, lead, etc. is becoming a major health concern. Some trace elements have been linked to neurotoxic effects and an increased risk of neurodevelopmental disorders, although there is still an area for further investigations on how they may affect neurological and psychiatric illnesses. It is widely acknowledged that the generation of reactive oxygen species causes oxidative damage and other detrimental health effects, and is the main mechanism underlying heavy metal-induced toxicity in contaminated drinking water. The aim: The main objective of this narrative review was to summarize the current knowledge regarding the concentrations of chosen trace elements in drinking water and their possible relationship with neurological and psychiatric disorders. Material and method: The available literature was reviewed using PubMed, Scopus, and Web of Sciences platforms. The analysis included both reviews and original studies. Discussion: Some elements such as aluminum, arsenic, lithium, or nickel have been suggested to be risk factors for psychoneurological disorders. Further, studies suggest that some neurobehavioral disorders might be due to the collective action of metals in drinking water. Keywords: trace elements; drinking water; contamination; neurological disorder; psychiatric disorder

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“…Peripheral neuropathy related to As exposure through drinking water was also reported in other studies [67,68]. As contaminated drinking water may also cause optic neuropathy [69,70]. Li et al (2020) explored the accumulation of As in various murine tissues, including different regions of the brain.…”

Section: Arsenicmentioning

confidence: 54%

Trace elements concentrations in drinking water – is there a risk for neurological or psychiatric disorders?

Januszewski,

Forma,

Sitarz

et al. 2023

Curr Probl Psychiatry

0

View full text Add to dashboard Cite

Introduction: Drinking water contaminated with heavy metals like arsenic, cadmium, nickel, mercury, chromium, zinc, lead, etc. is becoming a major health concern. Some trace elements have been linked to neurotoxic effects and an increased risk of neurodevelopmental disorders, although there is still an area for further investigations on how they may affect neurological and psychiatric illnesses. It is widely acknowledged that the generation of reactive oxygen species causes oxidative damage and other detrimental health effects, and is the main mechanism underlying heavy metal-induced toxicity in contaminated drinking water. The aim: The main objective of this narrative review was to summarize the current knowledge regarding the concentrations of chosen trace elements in drinking water and their possible relationship with neurological and psychiatric disorders. Material and method: The available literature was reviewed using PubMed, Scopus, and Web of Sciences platforms. The analysis included both reviews and original studies. Discussion: Some elements such as aluminum, arsenic, lithium, or nickel have been suggested to be risk factors for psychoneurological disorders. Further, studies suggest that some neurobehavioral disorders might be due to the collective action of metals in drinking water. Keywords: trace elements; drinking water; contamination; neurological disorder; psychiatric disorder

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“…The values of exposure to As in all eye drop samples were below the PDE limits established by the ICH Q3D guideline (R2) (15 µg/day). However, although the value of daily exposure to As through the instillation of lubricating eye drops is below the value established by the ICH Q3D guideline (R2), chronic exposure to this element can cause dermal effects, cardiovascular diseases, diabetes, cancers [ 48 ], eye irritation [ 49 ], conjunctivitis [ 50 ], and visual loss [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Quantification of Metal(loid)s in Lubricating Eye Drops Used in the Treatment of Dry Eye Disease

Oliveira,

Melo,

Silva

et al. 2023

Molecules

1

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The aim of the study was to evaluate the presence of metal(loid)s in lubricating eye drops used in the treatment of dry eye disease. The concentrations of Al, As, Ba, Cd, Co, Cu, Cr, Pb, Fe, Mg, Mn, Mo, Ni, Se, V, and Zn were determined in 19 eye drop samples using inductively coupled plasma optical emission spectrometry (ICP OES). The limit of detection (LOD) and limit of quantification (LOQ) values for the quantified elements ranged from 0.0002–0.0363 (mg/L) and 0.0007–0.1211 (mg/L), respectively. High values of concentrations of Al (2.382 µg/g), As (0.204 µg/g), Ba (0.056 µg/g), Cd (0.051 µg/g), Co (1.085 µg/g), Cr (0.020 µg/g), Cu (0.023 µg/g), Fe (0.453 µg/g), Mg (24.284 µg/g), Mn (0.014 µg/g), Mo (0.046 µg/g), Ni (0.071 µg/g), Pb (0.049 µg/g), Se (0.365 µg/g), V (0.083 µg/g), and Zn (0.552 µg/g) were quantified in samples of eye drops with and without preservatives. The concentrations of As (5 samples) and Cd (3 samples) were higher than those allowed by the Brazilian Pharmacopoeia for impurities (parenteral use). The value of Co content (µg/g) in a sample was higher than the value established by the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH Q3D (R2)) in the parenteral route. The daily eye drop instillation exposure (µg/day) was below the values from the parenteral-permitted daily exposure (PDE) set by the ICH Q3D guideline (R2). The presence of heavy metals in eye drops is an alert to regulatory agencies in several countries so that control and inspections can be carried out.

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Clinicopathological Correlates: Chronic Arsenic Toxicity Causing Bilateral Symmetric Progressive Optic Neuropathy

Cited by 9 publications

References 5 publications

Trace elements concentrations in drinking water – is there a risk for neurological or psychiatric disorders?

Trace elements concentrations in drinking water – is there a risk for neurological or psychiatric disorders?

Trace elements concentrations in drinking water – is there a risk for neurological or psychiatric disorders?

Quantification of Metal(loid)s in Lubricating Eye Drops Used in the Treatment of Dry Eye Disease

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