Rabbits may be infested by a variety of mites, such as fur mites, ear mites, or burrowing mites. Sarcoptes sp. mites are deep burrowing mites that affect the head, feet, nose, and areas around the genitalia. 1 Sarcoptic mange in rabbits is a highly infectious, nonseasonal, pruritic skin disease and is caused by Sarcoptes scabiei mites. Overcrowded living conditions and poor hygiene are essential factors for S. scabiei mites infestation. 2 Mites widely spread from rabbit to another rabbit by direct contact or through connection with an infested environment. 3 They can also spread from rabbits to other animals like cats or other pet animals if they are kept on the same premises. 4 One of the most important veterinary ectoparasites and cause greater weight loss, productivity, and quality of wool in rabbits are S. scabiei var. cuniculi. Previously, the possibility of zoonotic infection has been recorded. 5 It sparingly affects hairy rabbit parts such as the ears, nose, feet, and areas around the genitalia, resulting in hair loss, intense pruritus, hypertensive reaction, reduced body weight gain, and death. 6 Most of the sarcoptic mange is related to reduced feed consumption, digestibility, and rate of conversion with meningitis development. 7 Recently, many chemical agents are commonly used in veterinary clinics for the treatment and control of sarcoptic mange, and with certain drugs like ivermectin and abamectin, relatively good treatment efficacy has been achieved. However, in addition to the