Clinicopathological effects of diclazuril prophylaxis and treatment on rabbits experimentally infected with Eimeria stiedae

Allam, Tamer; AbdelGaber, Moustafa; Thabet, Nahed S.; AbouLaila, Mahmoud; Elkhatam, Ahmed

doi:10.21608/djvs.2020.92810

Cited by 6 publications

(4 citation statements)

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“…Conversely, rabbits in (G1, G2) had almost a normal liver at PM examination and the microscopical architecture of the liver indicating its protective effects of (G. glabra and Diclazuril) against E. stiedae infection which were in line with results previously recorded by Kardena et al (2015). Moreover, it was noticed that the liver lesions were completely ameliorated in histopathological hepatic damage by G1and G2 and the findings of the present study were consistent with the previous research (Allam et al, 2020;Seddiek and Metwally, 2013). This indicated that licorice extract recorded a decrease in the pathological reaction following Eimeria stiedae infection mainly by stimulating the cellular immune responses by the activation of host defense potentiators, through maturation, proliferation or differentiation of the immune cells.…”

Section: -Discussionsupporting

confidence: 92%

Ameliorative effect of alcoholic extract of Glycyrrhiza glabra and diclazuril against experimental Eimeria stiedae infection in rabbits

saleh

Ramadan

elakabawy

2023

Benha Veterinary Medical Journal

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The aim of the current study was to assess the hepato-protective role of Glycyrrhiza glabra (G. glabra) on hepatic coccidiosis in experimentally infected rabbits. Forty New Zealand rabbits were used in this study. Rabbits were randomly divided into four groups: G1; rabbits supplemented with Glycyrrhiza glabra extract, G2; the protected group was administrated diclazuril at a dose of (1mg/kg B.W) for a week before infection, G3; was kept as infected + nontreated (CP) and G4 was kept non-treated and non-infected (CN). Animals in G1 were supplemented with a daily dose of 300 mg/kg BW which began one week before infection and continued daily till the end of the experiment. On the 7 th day of the experiment, all groups except G4 were orally infected with 10 4 sporulated oocysts of Eimeria stiedae per rabbit using a stomach tube. Rabbits in all groups were examined for clinical signs, body weight, fecal oocysts count, hematological and biochemical parameters (liver, and kidney function), as well as histopathological lesion. The results showed a significant enhancement in clinical signs and body weight with a highly significant reduction in oocysts shedding, as well as a significant improvement in CBC and serum liver and kidney parameters in the botanical plant and diclazuril groups (G1, G2) when compared to infected control group. Finally, G. glabra has potential protective activity against E. stiedae in rabbits and could be applied as a safe and effective alternative product to protect rabbit from hepatic coccidiosis. Glycyrrhiza glabra Eimeria stiedae Rabbits Oocysts count serum hepatic enzyme

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Section: -Discussionsupporting

confidence: 92%

Ameliorative effect of alcoholic extract of Glycyrrhiza glabra and diclazuril against experimental Eimeria stiedae infection in rabbits

saleh

Ramadan

elakabawy

2023

Benha Veterinary Medical Journal

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“…The present study showed significant increases in GGT in group three as compared to group one (control group), this increase may be attributed to degenerative and necrotic changes in the epithelial lining of the bile duct (Allam et al, 2020), also the maintaining of GGT serum level in group four near to normal level (which was demonstrated in group one) was observed and illustrated a reasonable protective effect of O.M against the adverse degenerative effect of repeated s/c ivermectin injection.…”

Section: The Biochemical Analysissupporting

confidence: 71%

Hepato Renal Protective Effect of Origanum Majorana against Adverse Effect of Ivermectin in Rabbits

Elmahdy,

Elkalamawy

2022

AAVS

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The current study looked at the hepatic-renal protection of Origanum majorana "O.M" leaves extract in male rabbits against the negative effects of ivermectin. Twenty male rabbits were used and divided into four groups each group contain 5 rabbits as a following: Group one: rabbits which served as negative control were orally administered distilled water for 60 consecutive days. Group two: The rabbits in this group were given an aqueous extract of O.M. orally (200 milligrams per kilogram of body weight), once daily for 60 consecutive days. Group three: rabbits in this group received a subcutaneous therapeutic dose of ivermectin (200 micrograms per kilogram body weight), once monthly for 2 consecutive months. Group four: This group of rabbits was given an orally aqueous extract of O.M. (200 milligrams per kilogram of body weight) once daily for sixty consecutive days. and a subcutaneous therapeutic dose of ivermectin (200 micrograms per kilogram of body weight), once monthly for 2 consecutive months. The degree of hepatic protection was measured using liver enzymes activities (Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), alkaline phosphatase (ALP), g-Glutamyl transferase (GGT) and total bilirubin, also the levels of Cholesterol, Triglycerides, HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol were also estimated. The degree of renal protection was measured using creatinine, urea, sodium, potassium, also the levels of total protein, Albumin and Globulin were quantitated also the histo-pathological examination of the liver, kidneys were done. Results showed that the administration of O.M. extract restored the severely disrupted liver and kidney functions caused by ivermectin's unfavorable effect to almost normal levels as well as the co-administration of O.M. extract significantly reduced the histopathological effect of ivermectin on the liver and kidney. From our findings we concluded that the O.M. aqueous extract possessed a hepato-renal protective effect against ivermectin-induced adverse effects in rabbits.

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“…This effect could be due to the toxic effect of diclazuril on the liver tissue. In contrast, minimal or no histopathological changes in the liver of diclazuril-treated rabbits were reported [40,56,64].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Ficus sycomorus (Sycamore Fig) Extract on Intestinal Coccidiosis in Experimentally Infected Rabbits

Dawod

Fathalla

El‐Seedi

et al. 2022

Life

Self Cite

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This study was conducted to investigate the effect of the Ficus sycomorus extract on Eimeria intestinalis in experimentally infected rabbits. For this purpose, forty male 30-day-old rabbits (Blanc de Bouscat) were divided into four groups (n = 10 in each group). Rabbits kept in the first group served as negative control (non-treated-non-infected). Rabbits kept in the second, third, and fourth groups were challenged at 10 weeks old with 3 × 104E. intestinalis sporulated oocysts. The third and fourth groups were treated orally with diclazuril 10% (0.05 mg/kg body weight) and F. sycomorus (100 mg/Kg) for three consecutive days, respectively. The efficacy was assessed based on the growth performance parameters, clinical symptoms, oocyst shedding, histopathological findings, and hematological parameters for 16 days post challenge. The study revealed that rabbits treated with F. sycomorus methanolic extract and diclazuril showed mild clinical symptoms with a significant decrease in oocyst shedding compared with the positive control. Moreover, the diclazuril-treated group showed the highest leukocytic count and the lowest monocytes percentage compared with other groups. Furthermore, the lowest lymphocytes percentage was recorded in the control positive group. Histopathologically, moderate coccidia infestation in the intestinal mucosa and moderate hydropic degeneration of hepatocytes were observed in the diclazuril treated group compared with the negative control. However, mild coccidia infestation in the intestinal mucosa and slight coagulative necrosis of hepatocytes was found in the F. sycomorus treated group. In conclusion, F. sycomorus methanolic extract had promising effects on the live performance, oocyst count, and blood variables, while it possesses adverse consequences on the hepatic tissues. Further studies are required to optimize the dose and extraction method to mitigate its side effects.

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Clinicopathological effects of diclazuril prophylaxis and treatment on rabbits experimentally infected with Eimeria stiedae

Cited by 6 publications

References 0 publications

Ameliorative effect of alcoholic extract of Glycyrrhiza glabra and diclazuril against experimental Eimeria stiedae infection in rabbits

Ameliorative effect of alcoholic extract of Glycyrrhiza glabra and diclazuril against experimental Eimeria stiedae infection in rabbits

Hepato Renal Protective Effect of Origanum Majorana against Adverse Effect of Ivermectin in Rabbits

Efficacy of Ficus sycomorus (Sycamore Fig) Extract on Intestinal Coccidiosis in Experimentally Infected Rabbits

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